Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Admin Core

项目总结管理核心 行政(行政)核心的目标是为以下方面提供管理、监督和后勤支助 拟建JAX肌痛性脑脊髓炎/慢性疲劳综合征协同研究中心 (我/中心儿童研究中心)。管理核心的作用将是：1)促进日本宇宙航空研究开发机构内部富有成效的科学互动 ME/CFS CRC，涉及四个不同地点的12名调查人员(日本宇宙航空研究开发机构，康涅狄格大学， 北卡罗来纳州立大学贝特曼·霍恩中心)；2)保持JAX ME/CFS CRC的一致性 通过ME/CFS网络活动；3)监控研究项目、协作项目和 核心用于其特定的研究和资源共享目标；4)确保与 ME/CFS数据管理和协调中心(DMCC)；5)协调职业发展和 社区外展活动；以及6)管理Collaborative的征集、审查和选择 项目建议书。管理核心将由中心主任Derya Unutmaz博士领导，他是一位非常有成就的人 具有中心领导经验并与ME/CFS社区有深厚联系的免疫学家。Dr。 Unutmaz最近与临床合作伙伴贝特曼·霍恩卓越中心建立了临床联盟 在此应用上，对ME/CFS进行了研究。Unutmaz博士将利用与BHC和 拟议的社区影响指导委员会，作为主要利益攸关方反馈的来源，以及 传播ME/CFS研究的渠道。 管理核心将 利用卓越的能力、设施 和JAX提供的资源，用于管理大型协作研究项目和教育 活动。这些资源包括对全职、机构支持的中心管理员的支持，该管理员将 协助Unutmaz博士履行许多基本的中心职能。 一起， Unutmaz博士和中心 管理员将有效地执行以下具体目标：1)优化JAX的集成和功能 通过强有力的行政和科学监督，包括战略规划， 预算监督、冲突解决、关于研究活动方向的行政决定和 与其他ME/CFS中心的协作；2)加强JAX ME/CFS之间的沟通和协作 CRC调查人员以及ME/CFS中心和NIH代表之间；以及3)召开社区影响会议 指导委员会，并为ME/CFS患者、医生和 研究人员是ME/CFS研究的新手。

PROJECT SUMMARY ADMINISTRATIVE CORE The goal of the Administrative (Admin) Core is to provide management, oversight and logistical support for the proposed JAX Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center (ME/CFS CRC). The Admin Core's role will be to: 1) foster productive scientific interactions within the JAX ME/CFS CRC, which involves 12 investigators at four different locations (JAX, University of Connecticut, North Carolina State University, Bateman Horne Center); 2) maintain alignment of the JAX ME/CFS CRC with ME/CFS Network activities; 3) monitor the progress of research projects, collaborative projects, and cores towards their specific research and resource-sharing goals; 4) ensure efficient data sharing with the ME/CFS Data Management and Coordinating Center (DMCC); 5) coordinate career development and community outreach activities; and 6) administer the solicitation, review, and selection of Collaborative Project proposals. The Admin Core will be led by Center Director Dr. Derya Unutmaz, a highly accomplished immunologist with experience in Center leadership and a deep connection to the ME/CFS community. Dr. Unutmaz recently formed a clinical alliance withthe Bateman Horne Center of Excellence, the clinical partner on this application, to study ME/CFS. Dr. Unutmaz will leverage this connection with the BHC and with the proposed Community Impact Steering Committee as a source of feedback from key stakeholders as well as an outlet for dissemination of ME/CFS research. The Admin Core will leverage the excellent capabilities, facilities and resources offered at JAX for administering large-scale collaborative research projects and educational activities. These resources include support for a full time, institutionally supported Center Administrator, who will assist Dr. Unutmaz by performing many essential Center functions. Together, Dr. Unutmaz and the Center Administrator will effectively execute the following Specific Aims: 1) Optimize integration and function of JAX ME/CFS CRC activities through strong administrative and scientific oversight, including strategic planning, budgetary oversight, conflict resolution, executive decisions on the direction of research activities and collaborations with other ME/CFS Centers; 2) Enhance communication and collaboration among JAX ME/CFS CRC investigators and between ME/CFS centers and NIH representatives; and 3) Convene Community Impact Steering Committee and engage in education and outreach activities for ME/CFS patients, physicians, and investigators new to ME/CFS research.