Prospective predictors of risk and resilience trajectories of mental health in US youth during COVID-19

COVID-19 期间美国青少年心理健康风险和复原力轨迹的前瞻性预测因素

• 批准号: 10655685
• 负责人: Ran Barzilay
• 金额: $ 26.7万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655685
• 关键词: 13 year old; Address; Adolescence; Adolescent; Age; Anxiety; Back; Black race; Brain; COVID-19; COVID-19 pandemic; Chronic; Chronic stress; Clinical; County; Data; Data Analyses; Development; Dimensions; Early Intervention; Emotional; Environment; Environmental Exposure; Environmental Risk Factor; Exposure to; Financial Hardship; Fostering; Future; Genes; Genetic; Genotype; Global Warming; Goals; Growth; Health; Height; Household; Individual; Intervention; Life; Longitudinal Studies; Measures; Mental Depression; Mental Health; Mental disorders; Modeling; Neighborhoods; Neurocognitive; Outcome; Participant; Pattern; Persons; Phenotype; Post-Traumatic Stress Disorders; Preventive measure; Process; Psychiatry; Psychopathology; Research; Risk; Risk Factors; Risk Marker; SARS-CoV-2 infection; Sampling Studies; Schools; Social Interaction; Source; Stress; Symptoms; System; Teenagers; Time; Trauma; Youth; child depression; childhood anxiety; clinical phenotype; cognitive development; cohort; comparison group; coronavirus disease; deprivation; emotion regulation; experience; genetic information; improved; inter-individual variation; male; pandemic disease; pandemic stress; peer; pre-pandemic; preventive intervention; promote resilience; prospective; psychologic; recruit; resilience; resilience factor; response; risk stratification; sex; stress related disorder; stressor; structural determinants; substance use; suicidal behavior; trait; young adult

The COVID-19 pandemic has had substantial effects on youth in multiple aspects of life, raising concern about its impact on youth mental health. Indeed, mounting data suggest that youth depression and anxiety rates have increased compared to the pre-pandemic era. A key challenge is to recognize prospective predictors that can help identify youth at risk for serious mental health sequelae following COVID-19 and to disentangle the factors that contribute to resilient trajectories. Resilience, often defined as an adaptive outcome (i.e., low symptoms levels) following adversity, is driven by multiple systems including individual- and structural-level environmental factors, neurocognitive traits, and genetic factors. One approach to study resilience is to identify inter-individual variation in mental health trajectories following the pandemic, and use data collected prospectively before and early in the pandemic to better understands what determines variability in mental health trajectories under stress. The Adolescent Brain Cognitive Development (ABCD) Study (N~12,000, 52% male, recruited at age 9-10 years, 20% Black) follows diverse US youth longitudinally since 2017. The study collected multidimensional (i.e., environment, clinical, neurocognitive, genetic) data before the pandemic, and participants were ~12-13 years old when the pandemic hit. Between May 2020 to June 2021, the study team collected data on mental health and on COVID-19 related exposures at multiple time points from ~9,500 participants and will continue following participants into late adolescence. Therefore, ABCD Study creates a unique opportunity to disentangle risk and resilience factors collected prospectively in youth who were in early-mid adolescence when the pandemic hit, a critical developmental window when stress related disorders become more prevalent. In the current project, we propose to leverage the multi-dimensional ABCD Study data to identify factors that contribute to variability in mental health trajectories in US youth during the COVID-19 pandemic. We will first use latent growth mixture modeling to identify trajectories of internalizing symptoms over time. Thereafter, we will characterize the individual stressors and the structural (based on geocoded address) environmental exposures- before and early in the pandemic- that contribute to trajectories of risk and resilience (Aim 1). In addition, we will leverage the deep phenotyping that was conducted pre-COVID-19 to identify clinical and neurocognitive risk and resilience factors (Aim 2). Lastly, we will explore whether participants' genetic information (i.e., polygenic risk for psychiatric disorders) can help explain variability in mental health trajectories during the pandemic (Aim 3). The proposed research will identify what factors contribute to resilience (i.e., resilience factors); and who will show risk or resilience trajectory in response to chronic (pandemic-imposed) stress. The study addresses key gaps that are critical considering the expected chronic stress that is (and will likely keep being) imposed on youth due to the pandemic and other future adversities. Findings will improve risk stratification in youth exposed to chronic adversity and will identify targets for interventions aimed at enhancing resilience.

2019冠状病毒病大流行在生活的多个方面对青年产生了重大影响，令人担忧