Prospective predictors of risk and resilience trajectories of mental health in US youth during COVID-19
COVID-19 期间美国青少年心理健康风险和复原力轨迹的前瞻性预测因素
基本信息
- 批准号:10655685
- 负责人:
- 金额:$ 26.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:13 year oldAddressAdolescenceAdolescentAgeAnxietyBackBlack raceBrainCOVID-19COVID-19 pandemicChronicChronic stressClinicalCountyDataData AnalysesDevelopmentDimensionsEarly InterventionEmotionalEnvironmentEnvironmental ExposureEnvironmental Risk FactorExposure toFinancial HardshipFosteringFutureGenesGeneticGenotypeGlobal WarmingGoalsGrowthHealthHeightHouseholdIndividualInterventionLifeLongitudinal StudiesMeasuresMental DepressionMental HealthMental disordersModelingNeighborhoodsNeurocognitiveOutcomeParticipantPatternPersonsPhenotypePost-Traumatic Stress DisordersPreventive measureProcessPsychiatryPsychopathologyResearchRiskRisk FactorsRisk MarkerSARS-CoV-2 infectionSampling StudiesSchoolsSocial InteractionSourceStressSymptomsSystemTeenagersTimeTraumaYouthchild depressionchildhood anxietyclinical phenotypecognitive developmentcohortcomparison groupcoronavirus diseasedeprivationemotion regulationexperiencegenetic informationimprovedinter-individual variationmalepandemic diseasepandemic stresspeerpre-pandemicpreventive interventionpromote resilienceprospectivepsychologicrecruitresilienceresilience factorresponserisk stratificationsexstress related disorderstressorstructural determinantssubstance usesuicidal behaviortraityoung adult
项目摘要
The COVID-19 pandemic has had substantial effects on youth in multiple aspects of life, raising concern about
its impact on youth mental health. Indeed, mounting data suggest that youth depression and anxiety rates have
increased compared to the pre-pandemic era. A key challenge is to recognize prospective predictors that can
help identify youth at risk for serious mental health sequelae following COVID-19 and to disentangle the factors
that contribute to resilient trajectories. Resilience, often defined as an adaptive outcome (i.e., low symptoms
levels) following adversity, is driven by multiple systems including individual- and structural-level environmental
factors, neurocognitive traits, and genetic factors. One approach to study resilience is to identify inter-individual
variation in mental health trajectories following the pandemic, and use data collected prospectively before and
early in the pandemic to better understands what determines variability in mental health trajectories under stress.
The Adolescent Brain Cognitive Development (ABCD) Study (N~12,000, 52% male, recruited at age 9-10
years, 20% Black) follows diverse US youth longitudinally since 2017. The study collected multidimensional
(i.e., environment, clinical, neurocognitive, genetic) data before the pandemic, and participants were ~12-13
years old when the pandemic hit. Between May 2020 to June 2021, the study team collected data on mental
health and on COVID-19 related exposures at multiple time points from ~9,500 participants and will continue
following participants into late adolescence. Therefore, ABCD Study creates a unique opportunity to
disentangle risk and resilience factors collected prospectively in youth who were in early-mid adolescence
when the pandemic hit, a critical developmental window when stress related disorders become more prevalent.
In the current project, we propose to leverage the multi-dimensional ABCD Study data to identify factors that
contribute to variability in mental health trajectories in US youth during the COVID-19 pandemic. We will first use
latent growth mixture modeling to identify trajectories of internalizing symptoms over time. Thereafter, we will
characterize the individual stressors and the structural (based on geocoded address) environmental exposures-
before and early in the pandemic- that contribute to trajectories of risk and resilience (Aim 1). In addition, we will
leverage the deep phenotyping that was conducted pre-COVID-19 to identify clinical and neurocognitive risk and
resilience factors (Aim 2). Lastly, we will explore whether participants' genetic information (i.e., polygenic risk for
psychiatric disorders) can help explain variability in mental health trajectories during the pandemic (Aim 3). The
proposed research will identify what factors contribute to resilience (i.e., resilience factors); and who will show
risk or resilience trajectory in response to chronic (pandemic-imposed) stress. The study addresses key gaps
that are critical considering the expected chronic stress that is (and will likely keep being) imposed on youth due
to the pandemic and other future adversities. Findings will improve risk stratification in youth exposed to chronic
adversity and will identify targets for interventions aimed at enhancing resilience.
COVID-19大流行在生活的多个方面对青年产生了重大影响,引起了人们对以下问题的关注:
对青少年心理健康的影响。事实上,越来越多的数据表明,年轻人的抑郁和焦虑率
与大流行前相比有所增加。一个关键的挑战是认识到前瞻性的预测因素,
帮助识别2019冠状病毒病后有严重精神健康后遗症风险的青少年,并理清各种因素
有助于形成弹性轨迹。复原力,通常被定义为一种适应性结果(即,低症状
在逆境之后,由多个系统驱动,包括个人和结构层面的环境
因素、神经认知特征和遗传因素。研究弹性的一种方法是识别个体间的
流行病后心理健康轨迹的变化,并使用流行病前和流行病后前瞻性收集的数据,
在大流行病早期,更好地了解是什么决定了压力下心理健康轨迹的可变性。
青少年大脑认知发展(ABCD)研究(N~ 12,000,52%男性,招募年龄为9-10岁
自2017年以来,20%的黑人)纵向跟踪了不同的美国青年。该研究收集了多方面的
(i.e.,环境,临床,神经认知,遗传)数据,参与者约为12-13
10岁的时候流行病爆发了。在2020年5月至2021年6月期间,研究小组收集了有关精神疾病的数据,
健康和COVID-19相关暴露在多个时间点从约9,500名参与者,并将继续
跟踪参与者到青春期后期。因此,ABCD研究创造了一个独特的机会,
在青少年早期和中期前瞻性收集的风险和弹性因素
当大流行病来袭时,这是一个关键的发展窗口,与压力有关的疾病变得更加普遍。
在目前的项目中,我们建议利用多维ABCD研究数据来确定
在COVID-19大流行期间,导致美国青年心理健康轨迹的变化。我们将首先使用
潜在的增长混合建模,以确定随着时间的推移内化症状的轨迹。此后,我们将
描述个人压力源和结构性(基于地理编码地址)环境暴露-
在大流行之前和早期--这有助于风险和复原力的轨迹(目标1)。此外,我们将
利用COVID-19前进行的深度表型分析来识别临床和神经认知风险,
弹性系数(目标2)。最后,我们将探讨参与者的遗传信息(即,多基因风险
精神疾病)可以帮助解释大流行期间心理健康轨迹的变化(目标3)。的
拟议的研究将确定哪些因素有助于恢复力(即,弹性因素);以及谁将显示
应对慢性(流行病造成的)压力的风险或复原力轨迹。该研究报告述及关键差距
考虑到预期的长期压力(并可能继续)强加给年轻人,
应对大流行病和其他未来逆境。研究结果将改善暴露于慢性
将确定旨在加强复原力的干预措施的目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ran Barzilay其他文献
Ran Barzilay的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ran Barzilay', 18)}}的其他基金
Predicting suicide attempt in youth by integrating EHR, clinical, cognitive and imaging data
通过整合 EHR、临床、认知和影像数据来预测青少年自杀企图
- 批准号:
10038009 - 财政年份:2020
- 资助金额:
$ 26.7万 - 项目类别:
Mechanisms of resilience to developmental stress in children and adolescents.
儿童和青少年发展压力的恢复机制。
- 批准号:
10448271 - 财政年份:2019
- 资助金额:
$ 26.7万 - 项目类别:
Mechanisms of resilience to developmental stress in children and adolescents.
儿童和青少年发展压力的恢复机制。
- 批准号:
10210229 - 财政年份:2019
- 资助金额:
$ 26.7万 - 项目类别:
Mechanisms of resilience to developmental stress in children and adolescents.
儿童和青少年发展压力的恢复机制。
- 批准号:
9806213 - 财政年份:2019
- 资助金额:
$ 26.7万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 26.7万 - 项目类别:
Research Grant