Investigate interactive roles of environmental, behavioral and genetic factors on racial disparities in breast cancer outcomes
研究环境、行为和遗传因素对乳腺癌结果种族差异的交互作用
基本信息
- 批准号:10655049
- 负责人:
- 金额:$ 11.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministrative SupplementAfrican AmericanAgeAll of Us Research ProgramBehaviorBehavioralBehavioral GeneticsBiological MarkersBiomedical ResearchBody mass indexBreast Cancer PatientCaregiversCharacteristicsCommunitiesComplexComputer softwareConsensusDataData SetDatabasesDeath RateElectronic Health RecordEnvironmentEnvironmental Risk FactorEthnic OriginEtiologyGene ExpressionGeneticGenetic DatabasesGenetic Predisposition to DiseaseHealthHealth Disparities ResearchHealthcareHispanic PopulationsIncidenceIndividualInternetInterventionKnowledgeLinkMalignant NeoplasmsMeasurementMeasuresMediationMethodologyMethodsModelingOutcomeParticipantPatientsPhysical activityPlayPollutionProviderPublic HealthQuality of lifeRaceRecurrenceReduce health disparitiesRegistriesReportingResearchResearch PersonnelRisk FactorsRoleSmoking BehaviorStatistical MethodsSurveysTestingThe Cancer Genome AtlasUnited StatesVital StatusWomananalytical toolapplication programming interfacebreast cancer progressioncancer health disparitydata registrydemographicsdesigndisparity reductionepidemiology studyfollow-upgenetic informationhealth datahealth disparityhealth related quality of lifeimprovedmalignant breast neoplasmneoplasm registrynovelpersonalized medicineprecision medicineracial and ethnic disparitiesracial disparityrisk variantsocial determinantstreatment risktreatment strategytriple-negative invasive breast carcinomatumortumor progression
项目摘要
Project Summary:
Health disparities exist widely in the breast cancer outcomes (incidence, survival, and quality-of-life). When
compared with white women, African American women have higher recurrence and death rates from breast
cancer although they have a lower incidence rate. It is well established that both community and individual level
risk factors play important roles in breast cancer outcomes. In our previous studies, we have developed a
mediation analysis method to identify new biomarkers that contribute to health disparities in triple-negative breast
cancer (TNBC). We also developed a new multilevel mediation analysis method that allows for longitudinal
assessments of both residential environments and individual risk factors to be jointly utilized in determining the
mechanistic link between race and health outcomes. By including measures of individual and environmental
factors, our methods are capable of explaining existing disparities in health outcomes.In this project, we aim to
utilize the comprehensive database collected by the All of Us project to investigate the observed racial disparities
in breast cancer outcomes. Using the novel multilevel mediation analysis method, we will identify modifiable
factors that can explain the racial disparities observed in breast cancer outcomes. The risk factors to be
considered include measures at both the environmental (e.g. pollution measurements) and individual levels (e.g.,
smoking behavior and gene expressions). The information will help caregivers design precision medicine and
policymakers evaluate interventions that aim at improving treatment and reducing health disparities. We have
implemented our method as an R package (mlma) to provide the research community with open access to
software for performing multilevel mediation analysis. We plan to further develop an API for an interactive web
implementation of the software so that all researchers can use the method without the programming requirement.
项目概要:
健康差距广泛存在于乳腺癌的结果(发病率,生存率和生活质量)。当
与白色女性相比,非裔美国女性的乳腺癌复发率和死亡率更高,
癌症虽然发病率较低。众所周知,社区和个人层面
风险因素在乳腺癌预后中起着重要作用。在我们以前的研究中,我们开发了一种
中介分析方法,以确定有助于三阴性乳腺癌健康差异的新生物标志物
癌症(TNBC)。我们还开发了一种新的多层次中介分析方法,允许纵向
对居住环境和个人风险因素的评估,共同用于确定
种族和健康结果之间的机械联系。通过包括个人和环境的措施,
我们的方法能够解释健康结果中存在的差异。在这个项目中,我们的目标是
利用All of Us项目收集的综合数据库调查观察到的种族差异
乳腺癌的预后使用新的多级中介分析方法,我们将识别可修改的
这些因素可以解释在乳腺癌结果中观察到的种族差异。风险因素是
所考虑的措施包括环境(例如污染测量)和个人(例如,
吸烟行为和基因表达)。这些信息将帮助护理人员设计精准医疗,
决策者评价旨在改善治疗和减少健康差距的干预措施。我们有
将我们的方法实现为R包(mlma),为研究社区提供开放访问
用于执行多级中介分析的软件。我们计划进一步开发用于交互式Web的API
软件的实现,使所有的研究人员可以使用的方法,而无需编程的要求。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yaguang Xi其他文献
Yaguang Xi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yaguang Xi', 18)}}的其他基金
Developing LG007 as a novel therapeutic agent to treat triple negative breast cancer
开发 LG007 作为治疗三阴性乳腺癌的新型治疗剂
- 批准号:
10889411 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Sulindac sensitizes colorectal cancer to anti-PD-L1 therapy
舒林酸使结直肠癌对抗 PD-L1 疗法敏感
- 批准号:
10889412 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Interactions between ES-miRNAs and environmental risk factors are responsible for TNBC progression and associated racial health disparities: a novel analysis with multilevel moderation inferences
ES-miRNA 和环境风险因素之间的相互作用导致 TNBC 进展和相关种族健康差异:一项采用多级调节推论的新颖分析
- 批准号:
10594746 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
MiR-17 mediates sulindac anti-metastatic activity in human colorectal cancer
MiR-17 介导舒林酸在人结直肠癌中的抗转移活性
- 批准号:
10258119 - 财政年份:2022
- 资助金额:
$ 11.03万 - 项目类别:
Sulindac sensitizes colorectal cancer to anti-PD-L1 therapy
舒林酸使结直肠癌对抗 PD-L1 疗法敏感
- 批准号:
10538823 - 财政年份:2022
- 资助金额:
$ 11.03万 - 项目类别:
Developing LG007 as a novel therapeutic agent to treat triple negative breast cancer
开发 LG007 作为治疗三阴性乳腺癌的新型治疗剂
- 批准号:
10477444 - 财政年份:2021
- 资助金额:
$ 11.03万 - 项目类别:
Developing LG007 as a novel therapeutic agent to treat triple negative breast cancer
开发 LG007 作为治疗三阴性乳腺癌的新型治疗剂
- 批准号:
10313128 - 财政年份:2021
- 资助金额:
$ 11.03万 - 项目类别:
MicroRNA and colorectal cancer chemoprevention
MicroRNA 与结直肠癌化学预防
- 批准号:
9325302 - 财政年份:2015
- 资助金额:
$ 11.03万 - 项目类别:
MicroRNA and colorectal cancer chemoprevention
MicroRNA 与结直肠癌化学预防
- 批准号:
9313603 - 财政年份:2015
- 资助金额:
$ 11.03万 - 项目类别:
MicroRNA, a new player for the NSAID sulindac to prevent colon cancer progression
MicroRNA,NSAID 舒林酸预防结肠癌进展的新成员
- 批准号:
8707735 - 财政年份:2014
- 资助金额:
$ 11.03万 - 项目类别:
相似海外基金
A Longitudinal Qualitative Study of Fentanyl-Stimulant Polysubstance Use Among People Experiencing Homelessness (Administrative supplement)
无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
- 批准号:
10841820 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative Supplement
质子分泌上皮细胞作为附睾粘膜免疫的关键调节剂 - 行政补充
- 批准号:
10833895 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Administrative Supplement: Life-Space and Activity Digital Markers for Detection of Cognitive Decline in Community-Dwelling Older Adults: The RAMS Study
行政补充:用于检测社区老年人认知衰退的生活空间和活动数字标记:RAMS 研究
- 批准号:
10844667 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
StrokeNet Administrative Supplement for the Funding Extension
StrokeNet 资助延期行政补充文件
- 批准号:
10850135 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
2023 NINDS Landis Mentorship Award - Administrative Supplement to NS121106 Control of Axon Initial Segment in Epilepsy
2023 年 NINDS 兰迪斯指导奖 - NS121106 癫痫轴突初始段控制的行政补充
- 批准号:
10896844 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Biomarkers of Disease in Alcoholic Hepatitis Administrative Supplement
酒精性肝炎行政补充剂中疾病的生物标志物
- 批准号:
10840220 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
行政补充:利用非洲基因组改进遗传结构的推断和选择
- 批准号:
10891050 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Power-Up Study Administrative Supplement to Promote Diversity
促进多元化的 Power-Up 研究行政补充
- 批准号:
10711717 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Administrative Supplement for Peer-Delivered and Technology-Assisted Integrated Illness Management and Recovery
同行交付和技术辅助的综合疾病管理和康复的行政补充
- 批准号:
10811292 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别:
Administrative Supplement: Genome Resources for Model Amphibians
行政补充:模型两栖动物基因组资源
- 批准号:
10806365 - 财政年份:2023
- 资助金额:
$ 11.03万 - 项目类别: