CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program

这是CDC东南媒介传播疾病卓越中心的续签申请：Gateway 项目(SECVBD)由佛罗里达大学领导，既有成熟的合作，也有新兴的合作 有13所大学在美国东南部拥有强大的媒介生物学课程(美国)和波多黎各 里科。这个综合的学术网络承载着国家卫生部门的全面和综合的支持， 州和联邦农业机构、美国军事项目、国家和国际协会以及 当地的蚊子和病媒控制计划。我们的建议充分利用了广泛的基础知识 并应用媒介生物学和流行病学学科继续保持我们的成功 (I)建立公共卫生昆虫学综合实践社区的方案，包括 整个东南部的学术机构和地方、州和联邦公共卫生机构，以促进 现有和今后在病媒传播疾病监测和控制方面的努力；以及(2)扩大有效的 以学术、在线和实习为基础的基本公共卫生昆虫学培训计划，以扩大队列 接受过快速检测和应对VBDS所需知识和技能培训的人员 在全美范围内，以及(Iii)发起一系列基于证据的建议和量身定做的 “监测-反应计划”模板，以确保当地蚊子和病媒控制协会能够 更好地监控和控制美国的VBD。对于SECVBD的下一次迭代，我们利用 美国东南部和波多黎各扁虱和蚊媒疾病的生物复杂性和杠杆作用 集成的、数据驱动的应用研究计划，旨在在新的干预措施中产生最大产出 五年内的培训范例，以处理以下疾控中心优先事项： 对抑制寻找寄主的扁虱或扰乱病原体传播周期的新兴技术的评估； (B)进行实地研究，以优化防治硬虱产品的应用，为虫害提供建议 控制公司和房主如何优化滴答控制；(C)评估 将扁虱管理纳入现有的蚊子管理方案；(D)调查 关于蚊虫控制方法的知识、态度和行为，(E)评估现有 关于脑外伤风险和预防扁虱叮咬行为的公共教育方案；(F)对新出现的 抑制蚊子成虫的技术(抗药性)；(G)蚊子管理的实地评价 基于商业上可用的方法和产品(昆虫学和人类相关)的方法 (H)评价针对所有人的业务控制活动的有效性 蚊子阶段(包括抗药性)。目标是保持我们既定的、全面的、 应用和基础研究计划，以加深我们对VBD传播的了解，以预防VBD在 美国大陆和领地。

This is a renewal application for the CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program (SECVBD) led by the University of Florida with both well-established and burgeoning collaborations with 13 universities with strong vector biology programs across the Southeastern United States (U.S.) and Puerto Rico. This integrated academic network carries the full and integrated support of state departments of health, state and federal agricultural agencies, U.S. military programs, national and international associations, and >60 local mosquito and vector control programs. Our proposal leverages the expertise across a broad remit of basic and applied vector biology as well as epidemiological disciplines to continue to maintain the success of our program in (i) establishing an integrated community of practice in public health entomology consisting of academic institutions throughout the Southeast and local, state, and federal public health agencies, to facilitate existing and future efforts in vector-borne disease (VBD) surveillance and control and (ii) expanding an effective academic, online, and internship-based training program in basic public health entomology to augment the cohort of personnel who are trained with the requisite knowledge and skills to quickly detect and respond to VBDs across the U.S., and (iii) initiating the drive towards an evidence-based set of recommendations and a tailored template of a “surveillance-response program” to ensure that local mosquito and vector control associations can better monitor and control VBDs in the U.S. For the next iteration of the SECVBD, we take advantage of the biocomplexity of tick- and mosquito-borne diseases in the Southeastern U.S. and Puerto Rico and leverage an integrated, data-driven, applied research program designed to produce maximal output in novel interventions and training paradigms within a 5-year period to tackle the following CDC priorities: (a) Laboratory/field evaluations of emerging technologies to suppress host-seeking ticks or disrupt pathogen transmission cycles; (b) Field studies aimed at optimizing application of tick control products to provide recommendations for pest control firms and homeowners regarding how to optimize tick suppression; (c) Assessments of the potential for incorporating tick management into existing mosquito management programs; (d) Investigations on the knowledge, attitudes, & behaviors regarding tick control methodologies, (e) Evaluation of the impact of existing public education programs on TBI risk & behaviors to prevent tick bite; (f) Field evaluations of emerging technologies to suppress mosquito adults (insecticide resistance); (g) Field evaluations of mosquito management approaches based on commercially available methods and products (both entomological and human-related outcome measures); and (h) Evaluations of the effectiveness of operational control activities targeting all mosquito stages (including insecticide resistance). The goal is to maintain our established, comprehensive, applied, and basic research program to further our understanding of VBD transmission to prevent VBDs in the continental U.S. and territories.