Investigating Network Plasticity Effects of Repetitive Brain Stimulation Following Invasive and Noninvasive Methods in Humans

研究人类侵入性和非侵入性方法重复大脑刺激的网络可塑性效应

• 批准号: 10655436
• 负责人: Nicholas Thomas Trapp
• 金额: $ 18.68万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655436
• 关键词: Affect; Anterior; Antidepressive Agents; Area; Beds; Brain; Brain Diseases; Brain region; Clinical; Clinical Trials Design; Data; Disease remission; Electric Stimulation; Electroencephalography; Electrophysiology (science); Emotional; Environment; Epilepsy; Evoked Potentials; Future; Generations; Goals; Human; Implanted Electrodes; Individual; Insula of Reil; Intractable Epilepsy; Iowa; Lateral; Magnetic Resonance Imaging; Major Depressive Disorder; Maps; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Methods; Modality; Monitor; Moods; Operative Surgical Procedures; Outcome; Parietal Lobe; Patient Care; Patients; Pattern; Pharmaceutical Preparations; Physiologic pulse; Physiology; Prefrontal Cortex; Protocols documentation; Psychotherapy; Refractory; Reproducibility; Research; Resolution; Rest; Scalp structure; Seizures; Site; Stimulus; Structure; Surface; Techniques; Testing; Therapeutic; Therapeutic Uses; Training; Transcranial magnetic stimulation; Treatment Efficacy; Treatment Protocols; Universities; Work; antidepressant effect; career; cingulate cortex; depressed patient; design; disability; experience; hands-on learning; human subject; improved; indexing; magnetic resonance imaging/electroencephalography; neurophysiology; neuropsychiatric disorder; neuroregulation; new technology; novel; novel strategies; persistent symptom; repetitive transcranial magnetic stimulation; response; spatiotemporal; standard measure; targeted biomarker; tool; treatment response

Project Summary The goal of this Mentored Patient-Oriented Research Career Development Award (K23) application is to support the additional training, mentorship and experience needed to develop a new methodology for analyzing the effects of repetitive brain stimulation using intracranial electroencephalography (iEEG) in humans. One form of repetitive brain stimulation is transcranial magnetic stimulation (TMS). TMS has revolutionized the field of therapeutics for neuropsychiatric disorders – it is a novel, noninvasive treatment option used most commonly for medication-refractory major depressive disorder. Despite this, remission rates from its use are suboptimal and ideal stimulation parameters are unknown. Suboptimal outcomes are due in large part to our poor understanding of TMS neurophysiology and antidepressant effects. TMS is thought to work by altering brain excitability within a network of targeted brain structures; for depression, this target is an emotional network including the dorsolateral prefrontal cortex. The ability of the brain to change excitability in response to repeated stimuli is referred to as plasticity. Noninvasive methods of measuring plasticity, such as scalp EEG and magnetic resonance imaging (MRI), are often imprecise and unreliable. This project proposes a novel method to invasively characterize brain plasticity induced by intracranial stimulation (Aim 1) or TMS (Aim 2) with exquisite spatiotemporal resolution. The method involves using iEEG single-pulse evoked potentials to probe and quantify excitability change (a correlate of plasticity) after repetitive stimulation in epilepsy patients. Network connectivity profiles will be analyzed with both iEEG and resting state MRI (Aim 3) to provide a unique bridge between invasive and noninvasive physiology measures. This project tests the hypothesis that repetitive brain stimulation (delivered via TMS and intracranial stimulation) will alter brain excitability in a parameter-dependent manner, and these effects will be most pronounced within the nodes of the stimulated brain network. A better understanding of how repetitive stimulation propagates through brain networks and alters brain excitability will revitalize the to-date fruitless search for reproducible biomarkers of target engagement and treatment response with these new technologies. Novel aspects of this study include the use of TMS in human subjects with iEEG, and the unique combination of both invasive and noninvasive connectivity measures (iEEG and MRI) to deeply characterize network effects of stimulation. Future directions will be 1) using this method to evaluate and refine novel brain stimulation protocols to optimize plasticity and therapeutic efficacy, and 2) applying learned principles about network effects of repetitive stimulation to inform clinical trial design and therapeutic use in other brain disorders, such as depression. The University of Iowa and this mentor team provide a rich research environment and world-class facilities for implementing this proposal. These K23 activities align with my long-term career goal of optimizing therapeutic brain stimulation to improve patient care.

项目总结

项目成果

Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature.

创伤性脑损伤中创伤后应激障碍的神经影像学相关性：文献的系统回顾。

• DOI: 10.1089/neu.2021.0453
• 发表时间: 2023
• 期刊: Journal of neurotrauma
• 影响因子: 4.2
• 作者: Esagoff,AaronI;Stevens,DanielA;Kosyakova,Natalia;Woodard,Kaylee;Jung,Diane;Richey,LisaN;Daneshvari,NicholasO;Luna,LiciaP;Bray,MichaelJC;Bryant,BarryR;Rodriguez,CarlaP;Krieg,Akshay;Trapp,NicholasT;Jones,MelissaB;Roper
• 通讯作者: Roper

Behavioral and Emotional Dyscontrol Following Traumatic Brain Injury: A Systematic Review of Neuroimaging and Electrophysiological Correlates.

• DOI: 10.1016/j.jaclp.2022.05.004
• 发表时间: 2022-11
• 期刊: JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
• 影响因子: 2.3
• 作者: Bryant, Barry R.;Richey, Lisa N.;Jahed, Sahar;Heinzerling, Amanda;Stevens, Daniel A.;Pace, Benjamin D.;Tsai, Jerry;Bray, Michael J. C.;Esagoff, Aaron I.;Adkins, Jaxon;Cohen, Ilana;Narapareddy, Bharat R.;Rodriguez, Carla P.;Jones, Melissa B.;Roper, Carrie;Goldwaser, Eric L.;Lobner, Katie;Siddiqi, Shan;Sair, Haris, I;Lauterbach, Margo;Luna, Licia P.;Peters, Matthew E.;Trapp, Nicholas T.
• 通讯作者: Trapp, Nicholas T.

National Network of Depression Centers' Recommendations on Harmonizing Clinical Documentation of Electroconvulsive Therapy.

• DOI: 10.1097/yct.0000000000000840
• 发表时间: 2022-09-01
• 期刊: The journal of ECT
• 作者: Zandi PP;Morreale M;Reti IM;Maixner DF;McDonald WM;Patel PD;Achtyes E;Bhati MT;Carr BR;Conroy SK;Cristancho M;Dubin MJ;Francis A;Glazer K;Ingram W;Khurshid K;McClintock SM;Pinjari OF;Reeves K;Rodriguez NF;Sampson S;Seiner SJ;Selek S;Sheline Y;Smetana RW;Soda T;Trapp NT;Wright JH;Husain M;Weiner RD
• 通讯作者: Weiner RD

The Neuropsychiatric Approach to the Assessment of Patients in Neurology.

• DOI: 10.1055/s-0042-1745741
• 发表时间: 2022-04
• 期刊: SEMINARS IN NEUROLOGY
• 影响因子: 2.7
• 作者: Trapp, Nicholas T.;Martyna, Michael R.;Siddiqi, Shan H.;Bajestan, Sepideh N.
• 通讯作者: Bajestan, Sepideh N.