The long-term effectiveness of and the disparities in access to treatments for obstructive sleep apnea: a study on the All of Us data

阻塞性睡眠呼吸暂停治疗的长期有效性和获得治疗的差异：对我们所有人数据的研究

• 批准号: 10659816
• 负责人: Donglan Zhang
• 金额: $ 14.67万
• 依托单位: NYU LONG ISLAND SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-11 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659816
• 关键词: Affect; All of Us Research Program; American; Apnea; Arousal; Big Data; Biology; Black Populations; Cardiovascular Diseases; Cardiovascular system; Characteristics; Chronic; Clinical Trials; Code; Consensus; Continuous Positive Airway Pressure; Data; Databases; Diabetes Mellitus; Diagnosis; Disease; Disease Outcome; Effectiveness; Elderly; Enrollment; Environment; Event; Exposure to; Functional disorder; Goals; Health Services Accessibility; Healthcare; High Prevalence; Hispanic Populations; Hypoxemia; Individual; Knowledge; Lead; Life Style; Literature; Logistic Regressions; Long-Term Effects; Longitudinal Studies; Longitudinal cohort; Machine Learning; Mediation; Meta-Analysis; Minority; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Obstructive Sleep Apnea; Operative Surgical Procedures; Outcome; Oxidative Stress; Participant; Pathway interactions; Patients; Persons; Population; Precision therapeutics; Prevalence; Reduce health disparities; Research; Research Personnel; Risk; Sample Size; Severities; Sleep; Sleep Apnea Syndromes; Symptoms; Treatment outcome; United States; United States National Institutes of Health; alternative treatment; base; burden of illness; cardiovascular disorder risk; cardiovascular risk factor; comparative effectiveness; design; ethnic difference; ethnic minority; ethnic minority population; experience; health care availability; health data; health disparity; high risk; interest; men; mortality; neuropsychiatry; parent grant; personalized medicine; precision medicine; predictive modeling; racial and ethnic; racial and ethnic disparities; racial minority; respiratory; risk prediction model; social implication; socioeconomics; standard of care; treatment effect

Project Summary Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder that affects up to 38% of North Americans. OSA causes hypoxemia and oxidative stress that lead to increased risks of cardiovascular diseases, type 2 diabetes and various chronic conditions. It also contributes to health disparities as racial and ethnic minority groups are more likely to experience delay in diagnosis and treatment than non-Hispanic Whites, along with the fact that these minorities may have a higher prevalence of OSA. Treatments of OSA, including continuous positive airway pressure (CPAP) and upper airway surgery, are effective in relieving patients' hypopneic symptoms and therefore also thought to reduce the risks of these morbidities. However, previous studies on CPAP did not show significant impact on these outcomes and findings remain inconclusive due to poor compliance of the participants. In addition, literature regarding the long-term benefits of upper airway surgery is extremely lacking. It is also important to characterize OSA patients who will have higher risks of long-term morbidities. The proposed project will leverage the big data from the National Institutes of Health All of Us Research Program to study the long-term effects of CPAP and surgery on downstream morbidities, and to identify critical predictors for OSA patients who are at risk of these outcomes. In addition, the project aims to evaluate the racial and ethnical disparities in access to OSA treatment, and the mediation effect of socioeconomic and healthcare factors. The project, if successfully carried out, should have important scientific and social implications by providing a better understanding of the benefit of each treatment, facilitating personalized medicine, and reducing health disparities in OSA.

项目摘要 阻塞性睡眠呼吸暂停（OSA）是最常见的睡眠相关呼吸障碍， 高达38%的北美人。OSA导致低氧血症和氧化应激， 心血管疾病、2型糖尿病和各种慢性疾病的风险。它还 导致健康差异，因为种族和少数民族群体更有可能经历 延迟诊断和治疗比非西班牙裔白人，沿着的事实，这些 少数民族可能有更高的OSA患病率。OSA的治疗，包括持续的 气道正压通气（CPAP）和上气道手术，有效地缓解患者的呼吸困难， 呼吸不足症状，因此也被认为可以降低这些发病率的风险。 然而，先前关于CPAP的研究并未显示出对这些结果的显著影响， 由于参与者的遵守情况不佳，调查结果仍然没有定论。此外，文学 关于上呼吸道手术的长期益处是非常缺乏的。也很重要 描述OSA患者的特征，这些患者将具有较高的长期发病风险。拟议 该项目将利用美国国立卫生研究院全民研究计划的大数据 研究CPAP和手术对下游发病率的长期影响，并确定 这些结果的风险OSA患者的关键预测因素。此外，该项目旨在 评估获得OSA治疗的种族和民族差异，以及中介效应 社会经济和医疗保健因素。该项目如果成功实施， 通过更好地了解生物多样性的益处， 每次治疗，促进个性化医疗，减少OSA的健康差异。

项目成果

Antihypertensive Use and the Risk of Alzheimer's Disease and Related Dementias among Older Adults in the USA.

• DOI: 10.1007/s40266-022-00981-8
• 发表时间: 2022-11
• 期刊: DRUGS & AGING
• 影响因子: 2.8
• 作者: Pan, Xi;Zhang, Donglan;Heo, Ji Haeng;Park, Chanhyun;Li, Gang;Dengler-Crish, Christine M.;Li, Yan;Gu, Yian;Young, Henry N.;Lavender, Devin L.;Shi, Lu
• 通讯作者: Shi, Lu

Physical Activity Patterns and Cognitive Health among Older Adults in the United States.

• DOI: 10.1177/07334648221139480
• 发表时间: 2023-03
• 期刊: JOURNAL OF APPLIED GERONTOLOGY
• 影响因子: 3
• 作者: Li, Weixin;Li, Yan;Wen, Ming;Liu, Bian
• 通讯作者: Liu, Bian

Gender differential impact of bereavement on health outcomes: evidence from the China Health and Retirement Longitudinal Study, 2011-2015.

• DOI: 10.1186/s12888-020-02916-2
• 发表时间: 2020-10-22
• 期刊: BMC psychiatry
• 影响因子: 4.4
• 作者: Chen Z;Ying J;Ingles J;Zhang D;Rajbhandari-Thapa J;Wang R;Emerson KG;Feng Z
• 通讯作者: Feng Z

Spatiotemporal Optimization for the Placement of Automated External Defibrillators Using Mobile Phone Data.

使用手机数据对自动体外除颤器放置进行时空优化。

• DOI: 10.3390/ijgi12030091
• 发表时间: 2023
• 期刊: ISPRS international journal of geo-information
• 影响因子: 3.4
• 作者: Zhang,Jielu;Mu,Lan;Zhang,Donglan;Rajbhandari-Thapa,Janani;Chen,Zhuo;Pagán,JoséA;Li,Yan;Son,Heejung;Liu,Junxiu
• 通讯作者: Liu,Junxiu

Geographical and Temporal Analysis of Tweets Related to COVID-19 and Cardiovascular Disease in the US.

• DOI: 10.1080/19475683.2022.2133167
• 发表时间: 2022
• 期刊: ANNALS OF GIS
• 影响因子: 5
• 作者: Zhang, Xuan;Mu, Lan;Zhang, Donglan;Mao, Yuping;Shi, Lu;Rajbhandari-Thapa, Janani;Chen, Zhuo;Li, Yan;Pagan, Jose A.
• 通讯作者: Pagan, Jose A.