The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site

1.1.摘要 我们所有的研究计划（AoURP）的前7年伊利诺伊州精准医学 联盟（IPMC）奖为伊利诺伊州的精准健康合作创造了动力 这将为地方和国家留下几十年的积极遗产。前5年期间 在招生方面，IPMC从我们的机构差异中汲取了力量， 兴趣和专业知识，广泛的地理覆盖区域和多样化的患者人群。到 迄今为止，我们已经招募了来自芝加哥和大伊利诺伊州的近43,000名参与者， 占全国AoURP核心参与者的近10%-超过所有 通过高入学率（87%）对多样性的期望， 生物医学研究（UBR），尽管全国呈下降趋势。通过COVID-19 IPMC已经证明，我们可以在新的研究环境中发展和繁荣， 同时确保代表性。这一点很重要，因为AoURP寻求新的 目标人群（即，儿科）和实施方法。领导的经验 伊利诺伊州的AoURP产生了见解，知识，最佳实践，新想法和合作伙伴， 继续并加强我们在芝加哥和整个伊利诺伊州的工作。这包括承认 认识到真正和长期的接触在发展包容性 生物医学研究我们现在已经完全开发（并不断扩大）临床和 社区基础设施、利益相关者的支持和集成的工作流程。这些将继续 指导IPMC的绩效和实施战略，并得到有意参与的支持 投资和综合专门知识。我们已经确定了新的科学伙伴关系，在我们的健康 提供者组织（HPO）和MPI，现在包括一个额外的少数服务 具有重要UBR参与专业知识的MSI机构。IPMC提出这一建议， 满足或超过OTA-22-006感兴趣区域（AOI）的AoURP要求。下 AoURP和NIH的指导，对于AOI 1-社区，参与者和提供者参与， 招生和保留，我们将与AoURP领导和利益相关者在全国范围内， IPMC范围内的参与和招募有针对性的50，000不同的核心参与者在伊利诺伊州期间 五年奖励期。我们计划通过充分利用， 建立领导层和一线团队、基础设施、工作流程和新的参与 伙伴关系。我们将共同努力， AoURP概述的（主动和被动）里程碑，并充分执行协议， 随着国家方法、里程碑优先事项以及战略和优先事项的演变而灵活调整。到 为了实现这些目标，IPMC建议保持我们的HPO机构成员资格 （芝加哥大学、西北大学、伊利诺伊大学芝加哥分校、北岸 大学健康系统和拉什大学，与伊利诺伊大学分包合同 厄巴纳-香槟大学和伊利诺伊大学皮奥里亚分校），哈比卜·阿赫桑博士担任 联系PI和MPI Daviglus、Greenland、Aschebrook、Ho、Shah、Sanders、Pirzada和Soares。 我们还将增加与州长州立大学的重要参与伙伴关系，这是一个MSI， Drs.巴尔萨泽和罗伯森作为宪兵加入。在过去的5年里，IPMC合作伙伴 在平衡关键AoURP的同时， 指标（UBR参与度、高质量数据、注册和保留）。我们有信心 我们的5年计划将为AoURP带来重大价值， 伊利诺伊州的参与者群体，最终将实现发现和促进公平 在我们共同服务的社区和其他地方。

1.1. ABSTRACT The first 7 years of the All of Us Research Program (AoURP) Illinois Precision Medicine Consortium (IPMC) award has created an impetus for precision health collaboration in Illinois that will leave a positive legacy for decades both locally and nationally. During the first 5 years of enrollment, the IPMC has drawn strength from our institutional differences, varied scientific interests and expertise, broad geographic catchment areas, and diverse patient populations. To date, we have enrolled a cohort of nearly 43,000 participants from Chicago and greater Illinois, accounting for nearly 10% of the core AoURP participants nationwide – exceeding all expectations for diversity through high enrollment (87%) of those underrepresented in biomedical research (UBR), despite a decreasing trend nationally. Through the COVID-19 pandemic, the IPMC has proven that we can evolve and thrive in a new research context, pivoting operationally while ensuring representation. This is important as the AoURP seeks new target populations (i.e., pediatric) and implementation approaches. The experience of leading the AoURP in Illinois has generated insights, knowledge, best practices, new ideas, and partners to continue and build upon our work in Chicago and throughout Illinois. This includes a recognition of the crucial role that authentic and longstanding engagement plays in developing inclusive biomedical research. We now have fully developed (and constantly expanding) clinical and community infrastructure, stakeholder buy-in, and integrated workflows. These will continue to guide IPMC performance and implementation strategies, supported by intentional engagement investment and integrated expertise. We have identified new scientific partnerships at our Health Provider Organizations (HPOs) and MPIs, now including an additional minority serving institution (MSI) with significant UBR engagement expertise. The IPMC offers this proposal, to fulfill or exceed the AoURP requirements for OTA-22-006 Areas of Interest (AOIs). Under the direction of the AoURP and NIH, for AOI 1- Community, Participant and Provider Engagement, Enrollment and Retention, we will work with AoURP leadership and stakeholders nationally and IPMC-wide to engage and recruit a targeted 50,000 diverse core participants in Illinois during the 5-year award period. We plan to recruit at least 85% UBR into the AoURP by leveraging established leadership and frontline teams, infrastructure, workflows, and new engagement partnerships. We will work collectively to achieve the engagement, enrollment, and retention (active and passive) milestones outlined by the AoURP and implement the protocol fully and flexibly as national approaches, milestone priorities, and strategies and priorities evolve. To achieve these aims, the IPMC proposes to maintain our HPO institutional membership (University of Chicago, Northwestern University, University of Illinois Chicago, NorthShore University HealthSystem, and Rush University, with subcontracts at University of Illinois Urbana-Champaign and University of Illinois Peoria) with Dr. Habibul Ahsan serving as the contact PI with MPIs Daviglus, Greenland, Aschebrook, Ho, Shah, Sanders, Pirzada, and Soares. We will also add a crucial engagement partnership with Governors State University, an MSI with Drs. Balthazar and Roberson joining as MPIs. Over the last 5 years, IPMC partners have demonstrated complementary reach into diverse patient populations while balancing key AoURP metrics (UBR engagement, high quality data, enrollment, and retention). We are confident that our 5-year plan will bring significant value to the AoURP, with an engaged and diverse participant population based in Illinois that will ultimately enable discovery and promote equity in the communities we collectively serve and beyond.