University of Texas Southwestern - Stimulating Access to Research in Residency (UT-StARR) Program

德克萨斯大学西南分校 - 促进住院医师研究 (UT-StARR) 计划

• 批准号: 10655275
• 负责人: DWIGHT A. TOWLER
• 金额: $ 33.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655275
• 关键词: Address; Adult; Affect; Asian; Asian Indian; Biomedical Research; Black race; Blood; Breeding; Bronchopulmonary Dysplasia; Cardiovascular Diseases; Cessation of life; Childhood; Chronic Disease; Clinical; Clinical Research; Communities; Conceptions; Congenital Heart Defects; Cystic Fibrosis; Detection; Development; Diagnostic; Disease; Doctor of Medicine; Ensure; Environment; Equilibrium; Evaluation; Faculty; Foundations; Funding; Future; Hawaiian; Health; Heart; Heart Diseases; Hemophilia A; Hispanic; Hospitalization; Hospitals; Human; Individual; Institution; Internal Medicine; Intervention; Investigation; Laboratories; Longevity; Lung; Lung diseases; Maintenance; Medical Students; Mentors; Minority; Monitor; Outcome; Patient Recruitments; Patients; Pediatrics; Physicians; Population; Population Heterogeneity; Population Research; Prevention; Race; Research; Research Personnel; Research Priority; Research Training; Residencies; Risk; Scientist; Teaching Hospitals; Texas; Training; Training Programs; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Woman; career; design; disability; disease prognosis; experience; faculty mentor; health disparity; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; patient population; personalized medicine; population health; programs; recruit; skills; strength training

Project Abstract Despite decades of research in the understanding and treatment of diseases of the heart and lung, cardiovascular and pulmonary diseases remain the leading causes of hospitalization, disability, and death in the U.S. Notably, growing numbers of patients with childhood-onset chronic illnesses, such as congenital heart defects, cystic fibrosis, bronchopulmonary dysplasia, and hemophilia, are surviving into adulthood, making it imperative to conduct research encompassing the lifespan. Against this background of critical research needs, there is a strikingly growing shortage of M.D.-scientists, such that the proportion of M.D.s that remain primarily in research careers has decreased by 3-fold in the last 3 decades, despite the climbing number of total physicians in practice. The pipeline of M.D.-scientist development is also at risk: fewer medical students express interest in a research career, and fewer graduates apply for NIH funding. Importantly, relative to the overall physician workforce, women and minorities are disproportionately underrepresented in the proportion of M.D.-scientists. These challenges require the implementation of innovative recruitment and training strategies to feed the M.D.- scientist pipeline and ensure that women and minorities are well-represented. To help fill these critical gaps, we will establish the University of Texas Southwestern (UTSW) - Stimulating Access to Research in Residency (UT-StARR) training program to recruit and train a diverse group of Internal Medicine and Pediatrics residents that will become the next generation of M.D.-scientists conducting laboratory-based, translational, clinical, and population health research to detect, treat, and prognosticate diseases affecting the heart, lungs, and blood of diverse populations throughout the lifespan. Our institution will provide an ideal environment with a multidisciplinary cadre of funded research; robust didactic training program; and diverse patient population. We hypothesize that the 3 axes of diversity at UTSW - M.D. trainees, mentors, and patient community - afford the unique opportunity to address unmet needs in M.D. research training, personalized medicine, and population health. The following Aims organize our approach: Aim 1. To provide broad-based comprehensive mentored research training for a group of diverse Internal Medicine and Pediatric resident-investigators in the conception, design, and implementation of laboratory-based, translational, clinical, and population research in diseases affecting the heart, lungs and blood, encompassing detection, prevention, treatment, and outcomes to improve the health of individuals and populations throughout the human lifespan; Aim 2. To provide the essential research training and mentoring platform needed to build a strong foundation allowing successful transition of residents to independent M.D.-scientists conducting biomedical research in the heart, lung, and blood fields; Aim 3. To enhance the participation and persistence of M.D.s from underrepresented groups in research by implementation and maintenance of institutional mentored residency training programs involving diverse residents, mentors, and patients through evaluation and monitoring the progress of UT-StARR and other institutional training programs.

项目摘要 尽管在理解和治疗心肺疾病方面进行了数十年的研究， 心血管和肺部疾病仍然是导致住院、残疾和死亡的主要原因。 值得注意的是，越来越多的儿童慢性病患者，如先天性心脏病 缺陷、囊性纤维化、支气管肺发育不良和血友病都会存活到成年，使其 必须进行涵盖寿命的研究。在这一关键研究需求的背景下， 医学博士-科学家的短缺令人震惊，以至于医学博士的比例仍然主要是 在过去的30年里，尽管医生的总人数在攀升，但从事研究工作的人数减少了3倍 在实践中。医学博士-科学家培养的管道也处于危险之中：越来越少的医学生对 从事研究工作，申请NIH资助的毕业生越来越少。重要的是，相对于整体医生 劳动力、女性和少数族裔在医学博士比例中的比例过低--科学家 这些挑战要求实施创新的招聘和培训战略，以满足医学博士的需求。 科学家正在筹备工作，并确保妇女和少数群体有充分的代表性。为了帮助填补这些关键差距，我们 将建立德克萨斯大学西南分校(UTSW)--在 住院医师(UT-STARR)培训计划，招募和培训不同的内科和儿科群体 将成为下一代医学博士的住院医生-科学家进行以实验室为基础的、翻译的、 临床和人群健康研究，以检测、治疗和预测影响心脏、肺、 和不同种群的血液在整个生命周期内。我们的机构将提供一个理想的环境， 资助研究的多学科干部；强有力的教学培训计划；以及多样化的患者群体。我们 假设UTSW的三个多样性轴-医学实习生、导师和患者社区-提供 解决医学研究培训、个性化医疗和人口方面未得到满足的需求的独特机会 健康。以下目标组织了我们的方法：目标1.提供基础广泛的全面指导 对一批不同的内科和儿科住院医师进行概念上的研究培训， 设计和实施以实验室为基础的、转化的、临床的和人群疾病研究 影响心脏、肺和血液，包括检测、预防、治疗和结果改善 人一生中个人和群体的健康；目标2.提供必要的研究 培训和指导平台需要建立坚实的基础，使住院医生能够成功过渡 给独立医学博士--在心脏、肺和血液领域进行生物医学研究的科学家；目标3。 通过实施加强代表不足群体的医学博士在研究中的参与度和持久性 和维护机构指导的住院医师培训计划，涉及不同的住院医师、导师和 患者通过评估和监测UT-STAR等机构培训计划的进展情况。

项目成果

Novel Biomarkers of Kidney Disease in Advanced Heart Failure: Beyond GFR and Proteinuria.

晚期心力衰竭中肾脏疾病的新型生物标志物：超越GFR和蛋白尿。

• DOI: 10.1007/s11897-022-00557-y
• 发表时间: 2022-08
• 期刊: Current heart failure reports

Association of Ratio of eGFR by Cystatin C and Creatinine with Mortality in Heart Failure.

胱抑素 C 和肌酐的 eGFR 比率与心力衰竭死亡率的关联。

• DOI: 10.34067/kid.0000000000000384
• 发表时间: 2024
• 期刊: Kidney360
• 作者: Roehm,Bethany;McAdams,Meredith;Gordon,Jonathan;Grodin,JustinL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan

Patterns of Referral and Postdischarge Utilization of Cardiac Rehabilitation Among Patients Hospitalized With Heart Failure: An Analysis From the GWTG-HF Registry.

心力衰竭住院患者的转诊和出院后心脏康复利用模式：来自 GWTG-HF 登记处的分析。

• DOI: 10.1161/circheartfailure.122.010144
• 发表时间: 2023
• 期刊: Circulation. Heart failure
• 作者: Keshvani,Neil;Subramanian,Vinayak;Wrobel,ChristopherA;Solomon,Nicole;Alhanti,Brooke;Greene,StephenJ;DeVore,AdamD;Yancy,ClydeW;Allen,LarryA;Fonarow,GreggC;Pandey,Ambarish
• 通讯作者: Pandey,Ambarish

Specific Gravity Improves Identification of Clinically Significant Quantitative Proteinuria from the Dipstick Urinalysis.

比重可改善试纸尿液分析中临床显着的定量蛋白尿的识别。

• DOI: 10.34067/kid.0000000000000452
• 发表时间: 2024
• 期刊: Kidney360
• 作者: McAdams,MeredithC;Gregg,LParker;Xu,Pin;Zhang,Song;Li,Michael;Carroll,Ella;Kannan,Vaishnavi;Willett,DuWayneL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan