University of Texas Southwestern - Stimulating Access to Research in Residency (UT-StARR) Program

德克萨斯大学西南分校 - 促进住院医师研究 (UT-StARR) 计划

• 批准号: 10655275
• 负责人: DWIGHT A. TOWLER
• 金额: $ 33.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655275
• 关键词: Address; Adult; Affect; Asian; Asian Indian; Biomedical Research; Black race; Blood; Breeding; Bronchopulmonary Dysplasia; Cardiovascular Diseases; Cessation of life; Childhood; Chronic Disease; Clinical; Clinical Research; Communities; Conceptions; Congenital Heart Defects; Cystic Fibrosis; Detection; Development; Diagnostic; Disease; Doctor of Medicine; Ensure; Environment; Equilibrium; Evaluation; Faculty; Foundations; Funding; Future; Hawaiian; Health; Heart; Heart Diseases; Hemophilia A; Hispanic; Hospitalization; Hospitals; Human; Individual; Institution; Internal Medicine; Intervention; Investigation; Laboratories; Longevity; Lung; Lung diseases; Maintenance; Medical Students; Mentors; Minority; Monitor; Outcome; Patient Recruitments; Patients; Pediatrics; Physicians; Population; Population Heterogeneity; Population Research; Prevention; Race; Research; Research Personnel; Research Priority; Research Training; Residencies; Risk; Scientist; Teaching Hospitals; Texas; Training; Training Programs; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Woman; career; design; disability; disease prognosis; experience; faculty mentor; health disparity; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; patient population; personalized medicine; population health; programs; recruit; skills; strength training

Project Abstract Despite decades of research in the understanding and treatment of diseases of the heart and lung, cardiovascular and pulmonary diseases remain the leading causes of hospitalization, disability, and death in the U.S. Notably, growing numbers of patients with childhood-onset chronic illnesses, such as congenital heart defects, cystic fibrosis, bronchopulmonary dysplasia, and hemophilia, are surviving into adulthood, making it imperative to conduct research encompassing the lifespan. Against this background of critical research needs, there is a strikingly growing shortage of M.D.-scientists, such that the proportion of M.D.s that remain primarily in research careers has decreased by 3-fold in the last 3 decades, despite the climbing number of total physicians in practice. The pipeline of M.D.-scientist development is also at risk: fewer medical students express interest in a research career, and fewer graduates apply for NIH funding. Importantly, relative to the overall physician workforce, women and minorities are disproportionately underrepresented in the proportion of M.D.-scientists. These challenges require the implementation of innovative recruitment and training strategies to feed the M.D.- scientist pipeline and ensure that women and minorities are well-represented. To help fill these critical gaps, we will establish the University of Texas Southwestern (UTSW) - Stimulating Access to Research in Residency (UT-StARR) training program to recruit and train a diverse group of Internal Medicine and Pediatrics residents that will become the next generation of M.D.-scientists conducting laboratory-based, translational, clinical, and population health research to detect, treat, and prognosticate diseases affecting the heart, lungs, and blood of diverse populations throughout the lifespan. Our institution will provide an ideal environment with a multidisciplinary cadre of funded research; robust didactic training program; and diverse patient population. We hypothesize that the 3 axes of diversity at UTSW - M.D. trainees, mentors, and patient community - afford the unique opportunity to address unmet needs in M.D. research training, personalized medicine, and population health. The following Aims organize our approach: Aim 1. To provide broad-based comprehensive mentored research training for a group of diverse Internal Medicine and Pediatric resident-investigators in the conception, design, and implementation of laboratory-based, translational, clinical, and population research in diseases affecting the heart, lungs and blood, encompassing detection, prevention, treatment, and outcomes to improve the health of individuals and populations throughout the human lifespan; Aim 2. To provide the essential research training and mentoring platform needed to build a strong foundation allowing successful transition of residents to independent M.D.-scientists conducting biomedical research in the heart, lung, and blood fields; Aim 3. To enhance the participation and persistence of M.D.s from underrepresented groups in research by implementation and maintenance of institutional mentored residency training programs involving diverse residents, mentors, and patients through evaluation and monitoring the progress of UT-StARR and other institutional training programs.

项目摘要

项目成果

Novel Biomarkers of Kidney Disease in Advanced Heart Failure: Beyond GFR and Proteinuria.

晚期心力衰竭中肾脏疾病的新型生物标志物：超越GFR和蛋白尿。

• DOI: 10.1007/s11897-022-00557-y
• 发表时间: 2022-08
• 期刊: Current heart failure reports

Association of Ratio of eGFR by Cystatin C and Creatinine with Mortality in Heart Failure.

胱抑素 C 和肌酐的 eGFR 比率与心力衰竭死亡率的关联。

• DOI: 10.34067/kid.0000000000000384
• 发表时间: 2024
• 期刊: Kidney360
• 作者: Roehm,Bethany;McAdams,Meredith;Gordon,Jonathan;Grodin,JustinL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan

Patterns of Referral and Postdischarge Utilization of Cardiac Rehabilitation Among Patients Hospitalized With Heart Failure: An Analysis From the GWTG-HF Registry.

心力衰竭住院患者的转诊和出院后心脏康复利用模式：来自 GWTG-HF 登记处的分析。

• DOI: 10.1161/circheartfailure.122.010144
• 发表时间: 2023
• 期刊: Circulation. Heart failure
• 作者: Keshvani,Neil;Subramanian,Vinayak;Wrobel,ChristopherA;Solomon,Nicole;Alhanti,Brooke;Greene,StephenJ;DeVore,AdamD;Yancy,ClydeW;Allen,LarryA;Fonarow,GreggC;Pandey,Ambarish
• 通讯作者: Pandey,Ambarish

Specific Gravity Improves Identification of Clinically Significant Quantitative Proteinuria from the Dipstick Urinalysis.

比重可改善试纸尿液分析中临床显着的定量蛋白尿的识别。

• DOI: 10.34067/kid.0000000000000452
• 发表时间: 2024
• 期刊: Kidney360
• 作者: McAdams,MeredithC;Gregg,LParker;Xu,Pin;Zhang,Song;Li,Michael;Carroll,Ella;Kannan,Vaishnavi;Willett,DuWayneL;Hedayati,SSusan
• 通讯作者: Hedayati,SSusan