Center for Population Health and Aging

摘要/总结：我们提出了一个行政补充，以加强现有的纵向 达尼丁研究，根据NOSI-AG-22 - 022，"新的暴露措施和暴露相关机制 AD/ADRD结果。" NOSI呼吁建立新的研究基础设施，"解决 多个层面的不同物理、化学、社会、心理和经济暴露， 在AD/ADRD的病因学和社会差异的整个生命过程中。达尼丁研究，现在在其 第五个十年，一直领先于跟踪社会，心理和经济风险的领域，因为我们的队列的 出生于1972年，使用跨社会学，心理学，医学，牙科， 感官科学和经济学。在此，我们建议收集化学和物理接触数据， 达尼丁第52期。这样做将使这项研究成为世界上第一个真正的"经济学"调查之一 脑老化和AD/ADRD风险的关系。我们建议测量有毒金属，家庭环境 环境质量和周边环境质量。

Abstract/Summary: We propose an administrative supplement to enhance the existing longitudinal Dunedin Study with, per NOSI-AG-22-022, “new exposure measures and mechanisms linking exposures to AD/ADRD outcomes.” The NOSI calls for new research infrastructure that “addresses the role of diverse physical, chemical, social, psychological, and economic exposures across multiple levels and across the life course in the etiology and social disparities” of AD/ADRD. The Dunedin Study, now in its 5th decade, has led the field in tracking social, psychological, and economic exposures since our cohort’s birth in 1972, using multidisciplinary methods spanning sociology, psychology, medicine, dentistry, sensory science, and economics. Here we propose to collect chemical and physical exposure data at Dunedin Phase 52. Doing so will make the Study one of the world’s first truly “exposomic” investigations of life-course brain aging and AD/ADRD risk. We propose to measure toxic metals, home environmental quality, and neighborhood environmental quality.