Expanding the Gateway Research Infrastructure on Exposome Studies for the Health and Retirement Study and the Harmonized Cognitive Assessment Protocol International Network of Studies

摘要 构建资源，从高价值的公共数据中产生可广泛访问、（可重复）使用和可互操作的数据- 资助的队列研究是国家老龄化研究所在阿尔茨海默病（AD）方面的关键里程碑之一 AD相关痴呆症（ADRD）研究。全球老龄化数据门户（Gateway to Global Aging Data） 一个数据平台，用于协调和传播健康与退休研究及其 国际研究网络（HRS-INS），以促进对47个国家的老龄化问题进行纵向分析。我们 总体目标是通过纳入其他环境特征来扩展网关， 影响认知和AD/ADRD的发作和进展，收集和记录历史政策 教育的变化，协调来自两个统一认知评估的新可用元数据 北方爱尔兰和加勒比美洲（波多黎各和多米尼加）的方案（HCAP）研究 共和国），并为网关数据飞地编制统一的分析文件。整合 影响健康和行为结果的环境特征一直是 Gateway.在我们的母项目中，我们已经或将估计暴露于细颗粒物（PM2.5）在1公里 美国的决议，英国、爱尔兰、印度、中国、墨西哥和智利， 地面监测数据。这些数据已经与HRS，英国老龄化纵向研究（艾尔莎）， 印度纵向老龄化研究（Longitudinal Aging Study in India，LASI）更进一步，我们的目标是引入更多的开放数据 可能影响健康和认知的环境措施的来源，如二氧化氮（NO2）， 臭氧（O3）、环境空气温度、光污染以及对绿色和蓝色空间的访问。受快速发展的推动， 为了了解影响世界各地老年人的政策的演变，我们推出了网关政策探索者系列。 这一系列记录了在网关所涵盖的调查时实施的历史政策。到目前为止，我们的工作 重点关注退休和长期护理政策，我们的目标是通过汇编历史数据来扩大这项工作。 旨在影响各国教育质量的义务教育法律和政策的变化 并将此策略区域添加到网关的策略浏览器中。我们还将整合更多 关于教育的背景数据，如国家和年份的具体学习调整的受教育年限， 世界银行和其他相关背景变量，如国家、出生年份、性别和年龄别死亡率 人类死亡率数据库。为了快速传播，我们建立了网关数据飞地，一个新的 远程访问，NIA赞助的健康与老龄化数据（HaAD）飞地，供研究人员从他们的 自己的电脑。我们建议建立一个麻烦的分析模型，用于汇总的跨国分析， 晚年认知和痴呆及其风险因素，其中包括相关的环境暴露措施 以及教育政策的历史性变化。我们还将创建新的培训材料和指导文件 并组织一系列网络研讨会和一次面对面的用户研讨会。

Abstract Building resources to produce widely accessible, (re)usable, and interoperable data from high-value, publicly- funded cohort studies is one of the National Institute on Aging’s key milestones for the Alzheimer’s disease (AD) and AD-related dementia (ADRD) research implementation. The Gateway to Global Aging Data (Gateway) is a data platform developed to harmonize and disseminate data from the Health and Retirement Study and its international network of studies (HRS-INS) to facilitate longitudinal analyses on aging across 47 countries. Our overarching goal is to expand the Gateway by incorporating additional environmental characteristics that might influence cognition and the onset and progression of AD/ADRD, collecting and documenting historical policy changes in education, harmonizing newly available metadata from two Harmonized Cognitive Assessment Protocol (HCAP) studies in the Northern Ireland and the Caribbean America (Puerto Rico and Dominican Republic), and preparing harmonized analytical datafiles for the Gateway Data Enclave. Integrating environmental characteristics that influence health and behavioral outcomes has been an important aim of the Gateway. In our parent project, we have or will estimate exposure to fine particulate matter (PM2.5) at a 1-km resolution for the U.S., England, Ireland, India, China, Mexico, and Chile, using the satellite data together with ground monitor data. These data are already linked to the HRS, the English Longitudinal Study of Ageing (ELSA), and the Longitudinal Aging Study in India (LASI). Taking it a step further, we aim to bring in additional open data sources on environmental measures that might influence health and cognition, such as nitrogen dioxide (NO2), ozone (O3), ambient air temperature, light pollution, and access to green and blue spaces. Motivated by the rapid evolution of policies affecting older people across the world, we launched the Gateway Policy Explorer Series. This series captures historic policies in place at the time of surveys covered in the Gateway. Our work has so far focused on retirement and long-term care policies, and we aim to expand this work by compiling historical changes in compulsory schooling laws and policies aimed at affecting the quality of education for the countries with HCAP data and add this policy area to the Gateway’s Policy Explorer. We will also integrate additional contextual data on education, such as country-and-year specific learning-adjusted years of schooling from the World Bank, and other relevant contextual variables, such as country, birth year, sex, and age-specific mortality from the Human Mortality Database. For rapid dissemination, we have built the Gateway Data Enclave, a new remote-access, NIA-sponsored Health & Aging Data (HaAD) enclave, for researchers to access data from their own computers. We propose to construct an exposome analysis datafile for pooled cross-country analysis of late-life cognition and dementia and their risk factors, which includes linked environmental exposure measures and historic policy changes in education. We will also create new training materials and guidance documents and organize a series of webinars and an in-person user workshop.