Genetic Conflict Shapes Centromeres and Heterochromatin
Genetic Conflict Shapes Centromeres and Heterochromatin
批准号:
10654557
负责人:
HARMIT S MALIK
金额:
$37.4万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-07-01 至 2024-05-31
关键词:
AddressAdoptedAllelesAmino Acid MotifsAneuploidyAnimalsBehaviorBindingBiologicalBiological ProcessCellular biologyCentromereChromatidsChromosome SegregationChromosome abnormalityChromosomesConflict (Psychology)Congenital AbnormalityCytologyDNADNA Sequence AlterationDefectDepositionDown SyndromeDrosophila genusEmbryoEmbryonic DevelopmentEngineeringEnsureEpigenetic ProcessEukaryotaEvolutionFemaleFoundationsGene DuplicationGenesGeneticGenetic ModelsGenetic studyGenomeGenome engineeringHeterochromatinHistone H3HistonesInfertilityInheritedKinetochoresLeadMalignant NeoplasmsMediatingMeiosisMicrotubulesMitosisMitoticModelingMolecularMusNematodaOocytesOogenesisPhenotypePlantsProcessProteinsProteomicsRecurrenceRestRoleSatellite DNAShapesSiteSpermiogenesisTestingTransgenesVariantYeastsbasecostdevelopmental diseaseeggexpectationexperiencefitnessflygenetic analysisinsightinterdisciplinary approachknock-downneuronal cell bodyparalogous genepleiotropismprotein protein interactionrecruitsperm celltooltransmission process
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Chromosome segregation is an essential process. The key chromosomal sites that
ensure proper segregation of chromosomes are centromeres, which bind microtubules
that pull chromosomes or chromatids apart during meiosis and mitosis. Centromere
function is thus essential for chromosome segregation. Defective centromeres can lead
to aneuploidy, infertility, and birth defects like Down’s syndrome. Despite the
conservation of the chromosome segregation process, centromeric proteins like CenH3,
which bind centromeric DNA to assemble microtubule-recruiting kinetochores, evolve
rapidly between closely related species. Their rapid evolution is unexpected and could
imperil the fidelity of the chromosome segregation process. We previously proposed that
this rapid evolution occurs due to ‘centromere-drive’, i.e., competition between
chromosomes during female meiosis, in which only one of four meiotic products is
chosen to be the egg pronucleus. Using an approach that combines insights from
evolutionary genetics and cell biology, and state-of-the-art genome engineering tools, we
propose to test this model of genetic conflict in Drosophila species. Furthermore, based
on our finding of recurrent duplication of CenH3 in Drosophila species, we will test
whether somatic versus germline centromeric functions have different functional
constraints, which are easiest to resolve via gene duplication and specialization of
CenH3 genes.
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Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins.
果蝇 Cdc6(一种重要的 DNA 复制许可基因)的分子进化表明复制起点的适应性选择。
DOI:
10.4161/fly.4599
发表时间:
2007
期刊:
Fly
影响因子:
1.2
作者:
[Wiggins,BenjaminL, Malik,HarmitS]
通讯作者:
Malik,HarmitS
DOI:
10.1371/journal.pgen.1008520
发表时间:
2019
期刊:
PLoS genetics
影响因子:
4.5
作者:
[Lamelza,Piero, Young,JanetM, Noble,LukeM, Caro,Lews, Isakharov,Arielle, Palanisamy,Meenakshi, Rockman,MatthewV, Malik,HarmitS, Ailion,Michael]
通讯作者:
Ailion,Michael
Genetics: Master Regulator or Master of Disguise?
遗传学:监管大师还是伪装大师?
DOI:
10.1016/j.cub.2017.07.030
发表时间:
2017
期刊:
Current biology : CB
影响因子:
--
作者:
[Ailion,Michael, Malik,HarmitS]
通讯作者:
Malik,HarmitS
A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster.
细胞色素氧化酶的线粒体 DNA 亚型特别损害果蝇的雄性生育能力。
DOI:
10.7554/elife.16923
发表时间:
2016
期刊:
eLife
影响因子:
7.7
作者:
[Patel,MaulikR, Miriyala,GaneshK, Littleton,AimeeJ, Yang,Heiko, Trinh,Kien, Young,JanetM, Kennedy,ScottR, Yamashita,YukikoM, Pallanck,LeoJ, Malik,HarmitS]
通讯作者:
Malik,HarmitS
DOI:
10.1101/gad.280941.116
发表时间:
2016-05-15
期刊:
Genes & development
影响因子:
10.5
作者:
[Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW]
通讯作者:
Hetzer MW
共 42 条
eDyNAmiC - FREDHUTCH
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批准号:10625801
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项目类别:
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资助金额:$16.55万
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财政年份:2022
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负责人:HARMIT S MALIK
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依托单位:
eDyNAmiC - FREDHUTCH
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批准号:10845776
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项目类别:
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资助金额:$9.32万
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财政年份:2022
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负责人:HARMIT S MALIK
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Poxviral antagonism of the IFIT-mediated antiviral response
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批准号:8285705
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项目类别:
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资助金额:$22.0万
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财政年份:2012
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负责人:HARMIT S MALIK
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依托单位:
Poxviral antagonism of the IFIT-mediated antiviral response
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批准号:8415509
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项目类别:
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资助金额:$24.82万
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财政年份:2012
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:7251925
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项目类别:
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资助金额:$32.06万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic Conflict Shapes Centromeres and Heterochromatin
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批准号:9039091
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项目类别:
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资助金额:$35.22万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:8101936
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项目类别:
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资助金额:$35.87万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:8890953
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项目类别:
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资助金额:$11.53万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic Conflict Shapes Centromeres and Heterochromatin
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批准号:9221343
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项目类别:
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资助金额:$35.16万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic Conflict Shapes Centromeres and Heterochromatin
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批准号:8888585
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项目类别:
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资助金额:$35.3万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic Conflict Shapes Centromeres and Heterochromatin
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批准号:10411940
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项目类别:
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资助金额:$20.32万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:8292291
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项目类别:
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资助金额:$35.85万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:6910492
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项目类别:
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资助金额:$36.56万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:7629567
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项目类别:
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资助金额:$33.02万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:7447380
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项目类别:
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资助金额:$32.06万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic Conflict Shapes Centromeres and Heterochromatin
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批准号:10004659
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项目类别:
-
资助金额:$37.4万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:7067193
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项目类别:
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资助金额:$32.06万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:8499346
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项目类别:
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资助金额:$34.58万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
Genetic conflict shapes centromeres and heterochromatin
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批准号:7986005
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项目类别:
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资助金额:$36.26万
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财政年份:2005
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负责人:HARMIT S MALIK
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依托单位:
海外基金