Mechanisms controlling retinal responses to natural stimuli

总结和预期影响 拟议中的实验将提供一幅更清晰的图景，了解形成 灵长类动物视网膜对自然刺激的反应。初步结果表明，有几个重要的 洞察力。目标1：我们发现标准模型不能解释阳伞细胞对 自然图像。这些都是研究得最好的神经节细胞之一，标准的 用模型来解释他们的反应令人惊讶。具体地说，我们的结果表明 这些细胞跨越空间整合信号的方式高度依赖于刺激 当前模型未捕获的方式。目标2：我们发现感受野亚单位-Long 与双极细胞相关-可能具有比之前认识到的更多样化的特性 反映双极细胞以外的细胞的贡献。特别是，光依赖于光的变化 在评估亚单位的功能作用时，亚单位的大小将是重要的考虑因素。目标3：A 我们最近开发的工具揭示了光感受器后的重大贡献 视网膜神经节细胞反应动力学的机制。

Summary and expected impact The proposed experiments will provide a clearer picture of the mechanisms that shape responses to natural stimuli in the primate retina. Preliminary results suggest several important insights. Aim 1: We find that standard models fail to account for responses of On parasol cells to natural images. These are among the best-studied ganglion cells, and the inability of standard models to account for their responses is surprising. Specifically, our results suggest that the manner in which these cells integrate signals across space is highly stimulus-dependent in a manner not captured by current models. Aim 2: We find that receptive field subunits - long associated with bipolar cells - have more diverse properties than previously appreciated, likely reflecting contributions of cells other than bipolar cells. In particular, light-dependent changes in subunit size will be important to consider in evaluating the functional role of subunits. Aim 3: A tool that we recently developed reveals significant contributions of post-photoreceptor mechanisms to the kinetics of retinal ganglion cell responses.