Mechanisms controlling retinal responses to natural stimuli

控制视网膜对自然刺激反应的机制

• 批准号: 10655765
• 负责人: FREDERICK M RIEKE
• 金额: $ 38.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-05 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655765
• 关键词: Affect; Amacrine Cells; Behavioral; Biological; Cells; Code; Cone; Dependence; Device Designs; Engineering; Feedback; Image; Kinetics; Light; Mediating; Modeling; Photic Stimulation; Photoreceptors; Phototransduction; Primates; Process; Property; Retina; Retinal Cone; Retinal Ganglion Cells; Rod; Role; Shapes; Signal Transduction; Stimulus; Structure; System; Testing; Time; Vertebrate Photoreceptors; Vision; Work; artificial neural network; cell type; contrast enhanced; experimental study; ganglion cell; high dimensionality; horizontal cell; imaging properties; improved; insight; light intensity; neglect; neural model; neurotransmission; novel; predicting response; predictive modeling; receptive field; recruit; response; retinal neuron; retinal prosthesis; sight restoration; tool

Summary and expected impact The proposed experiments will provide a clearer picture of the mechanisms that shape responses to natural stimuli in the primate retina. Preliminary results suggest several important insights. Aim 1: We find that standard models fail to account for responses of On parasol cells to natural images. These are among the best-studied ganglion cells, and the inability of standard models to account for their responses is surprising. Specifically, our results suggest that the manner in which these cells integrate signals across space is highly stimulus-dependent in a manner not captured by current models. Aim 2: We find that receptive field subunits - long associated with bipolar cells - have more diverse properties than previously appreciated, likely reflecting contributions of cells other than bipolar cells. In particular, light-dependent changes in subunit size will be important to consider in evaluating the functional role of subunits. Aim 3: A tool that we recently developed reveals significant contributions of post-photoreceptor mechanisms to the kinetics of retinal ganglion cell responses.

摘要和预期影响 拟议的实验将提供一个更清晰的机制，塑造 灵长类视网膜对自然刺激的反应。初步结果表明，几个重要的 见解.目的1：我们发现标准模型不能解释对阳伞细胞的反应， 自然图像。这些是研究得最好的神经节细胞之一，而标准的神经节细胞不能被发现。 模型来解释他们的反应是令人惊讶的。具体来说，我们的研究结果表明， 这些细胞跨空间整合信号的方式是高度依赖于刺激的， 目前的模式无法捕捉到的方式。目的2：我们发现，感受野亚单位-长 与双极细胞相关-具有比以前认识到的更多样化的特性， 反映了除双极细胞以外的细胞的贡献。特别是， 在评估亚基的功能作用时，考虑亚基的大小是重要的。目标3：A 我们最近开发的一种工具揭示了后感光细胞的重要贡献， 视网膜神经节细胞反应的动力学机制。

项目成果

Receptive field center-surround interactions mediate context-dependent spatial contrast encoding in the retina.

感受野中心-周围相互作用介导视网膜中上下文相关的空间对比度编码。

• DOI: 10.7554/elife.38841
• 发表时间: 2018
• 期刊: eLife
• 影响因子: 7.7
• 作者: Turner,MaxwellH;Schwartz,GregoryW;Rieke,Fred
• 通讯作者: Rieke,Fred

Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.

• DOI: 10.1073/pnas.2121744119
• 发表时间: 2022-11-16
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

Identification of Multiple Noise Sources Improves Estimation of Neural Responses across Stimulus Conditions.

多个噪声源的识别改进了对刺激条件下神经反应的估计。

• DOI: 10.1523/eneuro.0191-21.2021
• 发表时间: 2021
• 期刊: eNeuro
• 影响因子: 3.4
• 作者: Weber,AlisonI;Shea-Brown,Eric;Rieke,Fred
• 通讯作者: Rieke,Fred

Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images.

• DOI: 10.7554/elife.70611
• 发表时间: 2022-03-14
• 期刊: eLife
• 影响因子: 7.7
• 作者: Yu Z;Turner MH;Baudin J;Rieke F
• 通讯作者: Rieke F