Mechanisms controlling retinal responses to natural stimuli

控制视网膜对自然刺激反应的机制

• 批准号: 9754831
• 负责人: FREDERICK M RIEKE
• 金额: $ 38.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-05 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754831
• 关键词: Architecture; Cells; Characteristics; Code; Collection; Complex; Cone; Dependence; Device Designs; Devices; Exhibits; Eye Movements; Failure; Human; Image; Individual; Knowledge; Location; Mediating; Modeling; Neurons; Neurophysiology - biologic function; Output; Photoreceptors; Phototransduction; Primates; Property; Retina; Retinal; Retinal Ganglion Cells; Retinal Photoreceptors; Role; Sensory; Shapes; Signal Transduction; Stimulus; Structure; Synapses; System; Testing; The Sun; Variant; Vision; Visual; Work; cell type; design; ganglion cell; gaze; improved; luminance; neural circuit; receptive field; recruit; response; retinal prosthesis; sensory stimulus; spatial integration; tool

We have made a tremendous amount of progress understanding sensory function. But this understanding fails to account for responses to natural stimuli. We propose to develop a mechanistic understanding of how natural stimuli are encoded in the primate retina through a combination of directed experimentation and quantitative modeling. This will encompass three aims: (1) determining the circuit mechanisms that explain striking differences in responses of On parasol ganglion cells to natural and artificial stimuli; (2) determining the origin, properties, and functional significance of the receptive field surround of retinal ganglion cells; and, (3) developing and applying new tools to reveal the importance of cone adaptation in shaping ganglion cell responses to natural stimuli.

我们在理解感官功能方面已经取得了巨大的进步。但是这种理解是错误的