ERICH-GENE

埃里希基因

• 批准号: 10655629
• 负责人: Christopher David Anderson
• 金额: $ 199.49万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10655629
• 关键词: Address; Adult; Affect; Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Amyotrophic Lateral Sclerosis; Asian population; Atrophic; Basement membrane; Biological; Biological Process; Black Populations; Blinded; Brain hemorrhage; Cause of Death; Cell Proliferation; Cerebral Amyloid Angiopathy; Cerebral hemisphere hemorrhage; Cerebral small vessel disease; Cerebrovascular Disorders; China; Clinical; Collaborations; Committee Members; Data; Data Set; Dementia; Disabled Persons; Disease; Endothelial Cells; Ensure; Ethnic Origin; Ethnic Population; Exclusion; Funding; Future; Genetic; Genetic Risk; Genomics; Genotype; Hematoma; Hemorrhage; Heterogeneity; Hispanic; Hispanic Populations; Hypertension; Image; Incidence; Individual; International; Intervention; Japan; Knowledge Portal; Leukoaraiosis; Life; Lobar; Location; Maintenance; Mental Depression; Meta-Analysis; Multiple Sclerosis; National Institute of Neurological Disorders and Stroke; Neurologic; Outcome; Parkinson Disease; Patients; Persons; Phenotype; Philosophy; Population; Predisposition; Prevention strategy; Principal Investigator; Publications; Publishing; Race; Research Design; Research Personnel; Resource Sharing; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Site; Stroke; Survivors; Syndrome; United States; United States National Institutes of Health; Variant; Vascular Dementia; White Matter Hyperintensity; Women' s Health; adjudication; biobank; clinical application; clinical care; clinical risk; cohort; cost effective; data sharing; design; disability; disease phenotype; ethnic difference; ethnic diversity; genetic association; genetic predictors; genetic risk assessment; genetic risk factor; genetic variant; genome sequencing; genome wide association study; genomic data; genomic locus; hypertension control; improved; innovation; insight; intraventricular hemorrhage; multi-ethnic; neuroimaging; novel; online resource; outcome prediction; patient population; patient stratification; polygenic risk score; predictive test; predictive tools; prognostic; prognostication; radiological imaging; recruit; risk stratification; sex; sharing platform; study population; therapeutic development; tool; whole genome

Project Summary/Abstract Stroke is the third leading cause of death and the leading cause of adult disability in the United States. More adults are affected by stroke each year than Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis or Parkinson’s disease. Intracerebral hemorrhage (ICH) represents the most severe subtype of stroke. An estimated 40-50% of ICH victims will die and more than 80% of survivors remain disabled. Patients with ICH share histopathological features with other forms of cerebral small vessel disease (CSVD) caused by hypertension and cerebral amyloid angiopathy. CSVD is a key component of progressive neurologic decline in Alzheimer’s disease and vascular dementia, and nearly half of ICH survivors develop dementia within 4 years. Our investigators have previously collaborated to publish the largest genome wide association study of ICH with ~1500 cases, which identified novel genetic factors that have since gone on to be replicated in CSVD phenotypes including white matter hyperintensity and small vessel stroke. With greater sample size, we will uncover additional risk factors for ICH and through those mechanisms, Alzheimer’s and vascular dementias. The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study originally recruited over 3000 cases of spontaneous hemorrhage with equal power among white, black and Hispanic cases. The study design begins with the philosophy that both ethnicity-specific and non-specific risk factors for ICH may exist, and numerous ERICH publications support this. We propose to combine additional ICH cases from around the world to maximize the power of our study to identify novel genetic variants across ethnicities. We have identified over 21,000 cases that have either completed genotyping or have samples available to assess genetic risk of ICH. However, the critical first step is to perform careful phenotype harmonization, specifically in location of hemorrhage which stratifies patients clinically, histopathologically, and genetically. Different studies have used different location definitions which if not harmonized will limit study power due to case misclassification. We have previously performed phenotype harmonization across our two centers for both ICH case status and location in >5,000 cases across 3 NIH-funded studies. We intend to complete harmonization on cases with available data, and expand harmonization to related imaging CSVD phenotypes and clinical outcomes. Next, we will combine genomic data to create polygenic risk scores (PRS) to stratify cumulative genetic risk of ICH at the individual level, which may provide a near-term opportunity to leverage genomic association data to improve clinical care. Finally, we will maximally share all association results and phentoypes through the Cerebrovascular Disease Knowledge Portal, a freely-accessible on-line collaborative resource established with NINDS support. If successful, we will have identified risk factors for ICH, subtypes by location and across CSVD neuroimaging features, which will be valuable as targets for rational therapeutic development. We will also have built PRS for ICH risk and outcome, as a tool to stratify individuals by ICH risk and provide prognostic information on outcomes.

项目总结/文摘

项目成果

Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.

• DOI: 10.1212/wnl.0000000000004255
• 发表时间: 2017-09-05
• 期刊: Neurology
• 影响因子: 9.9
• 作者: James ML;Langefeld CD;Sekar P;Moomaw CJ;Elkind MSV;Worrall BB;Sheth KN;Martini SR;Osborne J;Woo D;ERICH Investigators
• 通讯作者: ERICH Investigators

Infection after intracerebral hemorrhage: risk factors and association with outcomes in the ethnic/racial variations of intracerebral hemorrhage study.

• DOI: 10.1161/strokeaha.114.006435
• 发表时间: 2014-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Lord AS;Langefeld CD;Sekar P;Moomaw CJ;Badjatia N;Vashkevich A;Rosand J;Osborne J;Woo D;Elkind MS
• 通讯作者: Elkind MS

Hyperglycemia, Ischemic Lesions, and Functional Outcomes After Intracerebral Hemorrhage.

• DOI: 10.1161/jaha.122.028632
• 发表时间: 2023-07-04
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Lusk, Jay B.;Covington, Anna;Liu, Li;Weikel, Daniel P.;Li, Yi-Ju;Sekar, Padmini;Demel, Stacie L.;Aziz, Yasmin N.;Kidwell, Chelsea S.;Woo, Daniel;James, Michael L.
• 通讯作者: James, Michael L.

The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study protocol.

• DOI: 10.1161/strokeaha.113.002332
• 发表时间: 2013-10
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Woo D;Rosand J;Kidwell C;McCauley JL;Osborne J;Brown MW;West SE;Rademacher EW;Waddy S;Roberts JN;Koch S;Gonzales NR;Sung G;Kittner SJ;Birnbaum L;Frankel M;Testai FD;Hall CE;Elkind MS;Flaherty M;Coull B;Chong JY;Warwick T;Malkoff M;James ML;Ali LK;Worrall BB;Jones F;Watson T;Leonard A;Martinez R;Sacco RI;Langefeld CD
• 通讯作者: Langefeld CD

Corrigendum to 'Hemicraniectomy for Supratentorial Primary Intracerebral Hemorrhage: A Retrospective, Propensity Score Matched Study' [Journal of Stroke and Cerebrovascular Diseases, Vol. 28, No. 11 (November), 2019: 104361].

“幕上原发性脑出血的半颅切除术：回顾性倾向评分匹配研究”的勘误表[中风和脑血管疾病杂志，卷。

• DOI: 10.1016/j.jstrokecerebrovasdis.2020.104654
• 发表时间: 2020
• 期刊: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
• 作者: Gildersleeve,KaseyL;Hirzallah,MohammadI;Esquenazi,Yoshua;Moomaw,CharlesJ;Sekar,Padmini;Cai,Chunyan;Tandon,Nitin;Woo,Daniel;Gonzales,NicoleR
• 通讯作者: Gonzales,NicoleR