Multidisciplinary Research Training in Cardiovascular Disease

心血管疾病多学科研究培训

• 批准号: 10656528
• 负责人: Geoffrey S Pitt
• 金额: $ 39.55万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656528
• 关键词: Cardiovascular Diseases; Interdisciplinary Study; Research Training

PROJECT SUMMARY The successful sequencing of the human genome and the evolution of human health services research in the post-genomic era combined with startling advances in imaging technology have offered unprecedented opportunities to transform patient care in cardiovascular diseases. Over the past decade, Weill Cornell Medicine (WCM) has made major investments in biomedical research, as well as research training and infrastructure. WCM requests support for the research training of 4 clinical and non-clinical postdoctoral fellows in a new multidisciplinary research training program (MRTP) in Cardiovascular Disease, with WCM providing funding for an additional training slot. The objective is to recruit outstanding candidates with solid foundations in basic science and/or clinical research and train them to apply their knowledge and skills towards addressing important clinically unmet needs in the prevention, diagnosis, and treatment of patients with cardiovascular diseases. MRTP trainees will receive program support for 3 years during which they will follow a structured and rigorous postdoctoral training program. The MRTP will be a joint effort of 20 eminent preceptors from WCM, Memorial Sloan Kettering Cancer Center (MSKCC) and the Rockefeller University (RU), which constitute a dense network of collaborative researchers, who are international leaders in fields directly relevant to cardiovascular physiology and disease. These preceptors have been organized into 2 themed, but interconnected units of research training: molecular and cell signaling and cardiovascular imaging. These training units will enable the development of content-specific educational programming, as well as increase the efficiency administration within the training program. Oversight will be provided by a Research Training Executive Committee consisting of the Program Director and two Associate Program Directors, who will also serve as leaders of the training units, as well as 3 additional members who will provide specific guidance on clinical/epidemiologic research, on achieving and maintaining diversity within the training program, and on mentoring. We have also assembled an outstanding roster of internal and external advisory board members with a mandate to evaluate the program and provide specific recommendations to improve both its quality and efficiency. The MRTP's highly personalized training program will include 1) individual development plans; 2) rigorous research training; 3) hands-on experience in cutting-edge methodologies; and 4) an integrated curriculum. Trainees will further benefit from the extensive institutional resources of WCM, MSKCC and RU. Based upon the levels of interest in our fellowship programs, we anticipate a substantial pool of highly qualified clinical and non-clinical candidates for the proposed MRTP, which will maintain a strong diversity focus. Through its rigorous, structured and highly personalized curriculum, this new training program seeks to train future leaders in cardiovascular disease research who are prepared to translate their findings towards improving patient care.

项目摘要 人类基因组测序的成功和人类健康服务研究的发展 后基因组时代与成像技术的惊人进步相结合， 改变心血管疾病患者护理的机会。在过去的十年里，威尔康奈尔医学 (WCM)在生物医学研究以及研究培训和基础设施方面进行了大量投资。 WCM要求支持4名临床和非临床博士后研究员在一个新的 心血管疾病多学科研究培训计划（MRTP），WCM为以下项目提供资金： 一个额外的训练槽。我们的目标是招聘优秀的候选人，在基础扎实 科学和/或临床研究，并培训他们运用自己的知识和技能，以解决重要的 在预防、诊断和治疗心血管疾病患者方面的临床未满足需求。 MRTP学员将获得为期3年的计划支持，在此期间，他们将遵循结构化和严格的 博士后培养计划。MRTP将是来自WCM，Memorial 斯隆凯特琳癌症中心（MSKCC）和洛克菲勒大学（RU），构成了一个密集的网络 合作研究人员，他们是心血管生理学直接相关领域的国际领导者 和疾病这些导师被组织成两个主题，但相互关联的研究培训单元： 分子和细胞信号和心血管成像。这些培训单位将促进发展 具体内容的教育规划，以及提高效率的培训管理 程序.监督将由一个研究培训执行委员会提供， 主任和两名副项目主任，他们也将担任培训单位的领导人，以及3名 其他成员将在临床/流行病学研究、实现和 在培训计划中保持多样性，以及指导。我们还召集了一个杰出的 内部和外部咨询委员会成员的名册，其任务是评估该计划并提供 为提高其质量和效率提出了具体建议。MRTP高度个性化的培训 该计划将包括1）个人发展计划; 2）严格的研究培训; 3）在 先进的方法;和4）综合课程。学员将进一步受益于广泛的 WCM、MSKCC和RU的机构资源。根据对我们奖学金项目的兴趣程度， 我们预计将有大量高素质的临床和非临床候选人参加拟议的MRTP， 这将保持一个强大的多样性重点。通过其严格，结构化和高度个性化的课程， 这项新的培训计划旨在培养心血管疾病研究的未来领导者， 将他们的发现转化为改善病人护理。

项目成果

Five-Year Hospital Readmission After Coronary Artery Bypass Surgery and the Association With Off-Pump Surgery and Sex.

• DOI: 10.1161/jaha.122.028063
• 发表时间: 2023-04-18
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Dimagli, Arnaldo;Gaudino, Mario R.;An, Kevin R.;Olaria, Roberto Perezgrovas;Soletti, Giovanni, Jr.;Cancelli, Gianmarco;Harik, Lamia;Noiseux, Nicolas;Stevens, Louis-Mathieu;Lamy, Andre
• 通讯作者: Lamy, Andre

Sex differences in coronary artery bypass graft surgery outcomes: a narrative review.

• DOI: 10.21037/jtd-23-294
• 发表时间: 2023-09-28
• 期刊: Journal of thoracic disease
• 影响因子: 2.5

Angiographic Outcomes for Arterial and Venous Conduits Used in CABG.

• DOI: 10.3390/jcm12052022
• 发表时间: 2023-03-03
• 期刊: JOURNAL OF CLINICAL MEDICINE
• 影响因子: 3.9
• 作者: Dimagli, Arnaldo;Soletti Jr, Giovanni;Harik, Lamia;Olaria, Roberto Perezgrovas;Cancelli, Gianmarco;An, Kevin R.;Alzghari, Talal;Mack, Charles;Gaudino, Mario
• 通讯作者: Gaudino, Mario

Spinal cord injury after open and endovascular repair of descending thoracic aneurysm and thoracoabdominal aortic aneurysm: an updated systematic review and meta-analysis.

• DOI: 10.21037/acs-2023-scp-14
• 发表时间: 2023-09-28
• 期刊: ANNALS OF CARDIOTHORACIC SURGERY
• 影响因子: 3.1
• 作者: Alzghari, Talal;An, Kevin R.;Harik, Lamia;Rahouma, Mohamed;Dimagli, Arnaldo;Perezgorvas-Olaria, Roberto;Demetres, Michelle;Cancelli, Gianmarco;Soletti Jr, Giovanni;Lau, Christopher;Girardi, Leonard N.;Gaudino, Mario
• 通讯作者: Gaudino, Mario

Differences in Postoperative Atrial Fibrillation Incidence and Outcomes After Cardiac Surgery According to Assessment Method and Definition: A Systematic Review and Meta-Analysis.

• DOI: 10.1161/jaha.123.030907
• 发表时间: 2023-10-03
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4