Methods in Longitudinal Dementia (MELODEM) Initiative

纵向痴呆方法 (MELODEM) 计划

• 批准号: 10656310
• 负责人: Jennifer Weuve
• 金额: $ 5万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656310
• 关键词: Acceleration; Address; Adoption; Alzheimer' s Disease; Boston; Brain Diseases; California; Cognition; Collaborations; Communities; Complex; Consensus; Country; Data; Dementia; Development; Diagnostic; Discipline; Educational workshop; Epidemiologist; Etiology; Feedback; Fostering; Foundations; France; Future; Goals; Grant; Group Meetings; Heterogeneity; Human; Incidence; Institution; International; Leadership; Learning; Life Cycle Stages; Measurement; Mentors; Methodology; Methods; Neurologist; Online Systems; Paper; Participant; Persons; Phenotype; Prevention; Process; Publications; Publishing; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Research Proposals; Risk Factors; STEM research; San Francisco; Senior Scientist; Teaching Method; Time; Travel; Universities; Work; analytical method; career; cognitive reserve; design; doctoral student; follow-up; graduate student; improved; innovation; insight; meetings; member; multidisciplinary; prevent; public health priorities; symposium; working group

PROJECT ABSTRACT The search for effective strategies to prevent or treat Alzheimer's disease and related causes of dementia (ADRD) is a global public health priority. This search has been exceptionally difficult, reflecting the complex, multi-factorial processes culminating in ADRD, the diagnostic ambiguity, and the intrinsic challenges of research on diseases of the brain. Methods in Longitudinal Research on Dementia (MELODEM) is an international initiative to strengthen, harmonize, and promulgate analytic and design approaches for ADRD research. Launched in 2012, MELODEM convenes an international interdisciplinary group of researchers, including epidemiologists, neuropsychologists, neurologists, and biostatisticians, across career stages, to identify and address common methodologic challenges in quantitative research on ADRD. These methodologic challenges—such as selection/attrition, reverse causation, and measurement of cognition and dementia—have the potential to bias estimates of the extent to which risk factors protect against ADRD or slow the progression of ADRD. Some biases can be so extreme as to reverse the direction of estimated effects (e.g., protective instead of harmful association). For the past 5 years, MELODEM has convened an annual in-person meeting of 30-40 researchers and monthly web-based conference calls of methodologically themed working groups. The proposed meeting grant will support annual in-person MELODEM meetings to foster development and dissemination of valid and rigorous analytical approaches for quantitative research on the prevention and treatment of ADRD, with the goals of (a) developing new methods when needed, (b) reaching consensus on “best practices” for analytic methods, and (c) providing a platform to share and teach methods to junior and senior researchers. To continue working towards rigorous analytical approaches and “best practices,” the MELODEM annual progress meeting will include both “Data Workshops” and “Discussion Sessions” on topics relevant to current methodological challenges in ADRD research. The sessions will be led and moderated by leaders in the field and researchers ranging from graduate students to senior scientists will participate. The grant will also provide travel support for US researchers to participate in the annual meeting and ancillary activities. Finally, to sustain the collaborations and ideas discussed during the meeting, the grant will support post-meeting activities culminating in published reports from the collaborative research stemming from the conference and connections with a broader group of researchers not able to attend the meetings in person. These activities include web-based conference calls and small working group meetings. Support for the proposed MELODEM meetings will strengthen quantitative research methods related to ADRD, foster a collaborative, interdisciplinary community addressing the most important technical challenges, and promote rapid adoption of best-practices for solving shared technical challenges in ADRD research on prevention and treatment of ADRD.

项目摘要 寻找有效的策略来预防或治疗阿尔茨海默病和痴呆症的相关原因 ADRD是全球公共卫生优先事项。这一搜索异常困难，反映了复杂的， 最终导致ADRD的多因素过程、诊断模糊性以及 研究脑部疾病。痴呆症纵向研究方法（MELODEM）是一项 加强、协调和颁布可持续发展分析和设计方法的国际倡议 research. MELODEM成立于2012年，召集了一个国际跨学科研究小组， 包括流行病学家、神经心理学家、神经学家和生物统计学家， 确定并解决ADRD定量研究中常见的方法学挑战。这些方法论 挑战-如选择/磨损，反向因果关系，以及认知和痴呆的测量-已经 对风险因素预防ADRD或减缓进展的程度的估计可能存在偏倚 的ADRD。有些偏差可能非常极端，以至于逆转了估计效果的方向（例如，保护 而不是有害的联系）。在过去的5年里，MELODEM每年都召开一次面对面的会议， 30-40名研究人员参加，每月举行一次方法专题工作组的网络电话会议。 拟议的会议补助金将支持MELODEM年度面对面会议，以促进发展， * 传播有效和严格的分析方法，对预防和 ADRD的治疗，目标是（a）在需要时开发新方法，（B）就 分析方法的“最佳做法”，以及（c）提供一个平台， 资深研究员。为了继续努力采用严格的分析方法和“最佳做法”， MELODEM年度进展会议将包括“数据研讨会”和“讨论会”， 与ADRD研究中当前的方法学挑战相关。会议将由以下人员主持 该领域的领导者和研究人员，从研究生到高级科学家都将参加。的 这笔赠款还将为美国研究人员参加年会和附属会议提供旅费支持 活动最后，为了维持会议期间讨论的合作和想法，赠款将支持 会后活动最终发表了来自合作研究的报告， 会议和与更广泛的研究人员群体的联系无法亲自参加会议。 这些活动包括网上电话会议和小型工作组会议。支持 拟议的MELODEM会议将加强与ADRD有关的定量研究方法， 协作，跨学科社区解决最重要的技术挑战，并促进 快速采用最佳做法，解决ADRD预防研究中的共同技术挑战， ADRD的治疗