Nutrition, Exercise and phenotype Testing Core

摘要/摘要-下一个核心 MNORC营养、运动和表型测试(NEXT)核心的总体目标 (以前的“人类表型核心”(HPC)是为了加强和扩大研究 MNORC研究人员执行与以下相关的临床和翻译研究的能力 营养、肥胖和/或与肥胖相关的人类疾病。下一个核心实现了这一点 目标：1)为翻译、临床和人群提供咨询服务 调查人员关于适当的评估、测试和/或干预方法 与营养、体力活动/锻炼、肥胖或肥胖相关的心脏相关的研究 代谢紊乱，2)为复杂和标准化提供专业知识和基础设施 人体受试者的生理测试，包括儿童和成人3)提供服务 直接协助研究人员进行营养和/或体力活动/锻炼 对人类受试者的干预，以及4)协助开发新技术或 获取人类代谢表型的新技术。除了提供广泛的 相对“标准”的表型测量(例如，人体测量和身体成分 (DXA，PeaPod)，血压，空腹血功，口服糖耐量，营养和 通过自我报告和客观方法评估体力活动(试餐、 加速度量学)和有氧体能评估)，下一个核心还提供更多 涉及更彻底地评估代谢表型的程序(例如， 高胰岛素-正常血糖钳夹、同位素示踪代谢研究、静息能量 支出、骨骼肌和脂肪组织活检)。在开始学习之前， MNORC调查人员可以咨询专家NeXT核心人员，以了解如何 可用的方法可能会帮助他们测试他们的假设，并潜在地扩展他们的 使用通过核心提供给他们的工具来研究问题。下一个核心 人员还咨询MNORC调查人员，以帮助优化他们的研究设计和他们的 研究干预策略/方法。下一个核心也直接协助MNORC 调查人员通过提供以下服务进行肥胖/营养干预： 与研究参与者进行营养咨询，监督运动训练干预措施， 在干预期间对身体活动和饮食行为的评估，以及 协助实施专门针对每个研究参与者的干预措施。 总体而言，下一个核心的服务提供了受控良好和标准化的表型 测试，最先进的技术，用于更深入的表型评估，以及帮助 实施控制良好的研究干预措施，所有这些措施都大大增强和扩大了 研究人员在儿童营养和肥胖领域使用的现有方法 成年人。

Abstract/Summary – NExT Core The overall objective of the Nutrition, Exercise and phenotype Testing (NExT) core of MNORC (formerly the “Human Phenotyping Core” (HPC) is to enhance and expand the research capabilities of MNORC investigators performing clinical and translational studies related to nutrition, obesity, and/or obesity-related disorders in humans. The NExT core accomplishes this goal by: 1) Provide consultation services to translational, clinical and population-based investigators regarding appropriate assessment, testing and/or intervention approaches for their studies related to nutrition, physical activity/exercise, obesity, or obesity-related cardio- metabolic disorders, 2) offering expertise and infrastructure for sophisticated and standardized physiologic testing of human subjects, including children and adults 3) providing services to directly assist researchers to conduct their nutritional and/or physical activity/exercise interventions in human subjects, and 4) assisting in the development of new techniques or acquire new technologies for human metabolic phenotyping. In addition to offering a wide array of relatively “standard” phenotypic measurements (e.g., anthropometry and body composition (DXA, PeaPod), blood pressure, fasting blood work, oral glucose tolerance, nutritional and physical activity assessments via self reports and objective methods (test meals, accelerometry), and aerobic fitness assessments) the NExT core also offers several more involved procedures to more thoroughly assess the metabolic phenotype (e.g., hyperinsulinemic-euglycemic clamp, isotope-tracer metabolic studies, resting energy expenditure, skeletal muscle and adipose tissue biopsies). Before beginning their studies, MNORC investigators may consult with expert NExT core personnel to gain insights on how the available methodologies may help them to test their hypotheses, and potentially expand their research questions using the tools made available to them through the Core. NExT core personnel also consult with MNORC investigators to help optimize their study designs and their research intervention strategies/approaches. The NEXT core also directly assists MNORC investigators to conduct their obesity/nutritional interventions by providing services such as: nutritional consultations with study participants, supervision of exercise training interventions, assessment of physical activity and dietary behaviors during an intervention, as well as assistance with conducting interventions specifically tailored to each research participant. Overall, the services of the NExT core provide well-controlled and standardized phenotypic testing, state-of-the-art techniques for “deeper” phenotype assessment, as well as assistance to conduct well-controlled research interventions, all of which greatly enhance and expand on existing approaches used by researchers in the areas of nutrition and obesity in children and adults.