Nutrition, Exercise and phenotype Testing Core

摘要/总结- NExT核心 MNORC营养、运动和表型测试（NExT）核心的总体目标 （以前的“人类表型核心”（HPC）是为了加强和扩大研究 MNORC研究者进行临床和转化研究的能力， 营养、肥胖症和/或肥胖症相关病症。NExT核心实现了这一点 目标：1）提供翻译，临床和人口为基础的咨询服务 研究者关于其适当的评估、检测和/或干预方法， 与营养、体力活动/锻炼、肥胖或肥胖相关的心血管疾病相关的研究， 代谢紊乱，2）提供专业知识和基础设施， 人类受试者的生理测试，包括儿童和成人3）提供服务， 直接协助研究人员进行营养和/或体力活动/锻炼 对人类受试者的干预，以及4）协助开发新技术或 获得人类代谢表型分析的新技术。除了提供广泛的 相对“标准”的表型测量（例如，人体测量和身体组成 (DXA，PeaPod），血压，空腹血液工作，口服葡萄糖耐量，营养和 通过自我报告和客观方法（测试餐， 加速度计）和有氧健身评估），NExT核心还提供了几个 涉及更彻底地评估代谢表型的程序（例如， 高胰岛素-正葡萄糖钳夹，同位素示踪代谢研究，静息能量 消耗、骨骼肌和脂肪组织活组织检查）。在开始学习之前， MNORC调查人员可能会咨询专家NExT核心人员，以了解 现有的方法可以帮助他们测试他们的假设，并有可能扩大他们的 使用通过核心提供给他们的工具研究问题。NExT核心 工作人员还与MNORC研究人员进行咨询，以帮助优化他们的研究设计和 研究干预战略/方法。NEXT核心还直接协助MNORC 研究人员通过提供以下服务进行肥胖/营养干预： 与研究参与者进行营养咨询，监督运动训练干预， 在干预期间评估身体活动和饮食行为，以及 协助进行专门针对每个研究参与者的干预措施。 总的来说，NExT核心的服务提供了良好控制和标准化的表型 测试，最先进的技术，“更深入”的表型评估，以及援助， 进行控制良好的研究干预，所有这些都大大提高和扩大 研究人员在儿童营养和肥胖领域使用的现有方法， 成年人了

Abstract/Summary – NExT Core The overall objective of the Nutrition, Exercise and phenotype Testing (NExT) core of MNORC (formerly the “Human Phenotyping Core” (HPC) is to enhance and expand the research capabilities of MNORC investigators performing clinical and translational studies related to nutrition, obesity, and/or obesity-related disorders in humans. The NExT core accomplishes this goal by: 1) Provide consultation services to translational, clinical and population-based investigators regarding appropriate assessment, testing and/or intervention approaches for their studies related to nutrition, physical activity/exercise, obesity, or obesity-related cardio- metabolic disorders, 2) offering expertise and infrastructure for sophisticated and standardized physiologic testing of human subjects, including children and adults 3) providing services to directly assist researchers to conduct their nutritional and/or physical activity/exercise interventions in human subjects, and 4) assisting in the development of new techniques or acquire new technologies for human metabolic phenotyping. In addition to offering a wide array of relatively “standard” phenotypic measurements (e.g., anthropometry and body composition (DXA, PeaPod), blood pressure, fasting blood work, oral glucose tolerance, nutritional and physical activity assessments via self reports and objective methods (test meals, accelerometry), and aerobic fitness assessments) the NExT core also offers several more involved procedures to more thoroughly assess the metabolic phenotype (e.g., hyperinsulinemic-euglycemic clamp, isotope-tracer metabolic studies, resting energy expenditure, skeletal muscle and adipose tissue biopsies). Before beginning their studies, MNORC investigators may consult with expert NExT core personnel to gain insights on how the available methodologies may help them to test their hypotheses, and potentially expand their research questions using the tools made available to them through the Core. NExT core personnel also consult with MNORC investigators to help optimize their study designs and their research intervention strategies/approaches. The NEXT core also directly assists MNORC investigators to conduct their obesity/nutritional interventions by providing services such as: nutritional consultations with study participants, supervision of exercise training interventions, assessment of physical activity and dietary behaviors during an intervention, as well as assistance with conducting interventions specifically tailored to each research participant. Overall, the services of the NExT core provide well-controlled and standardized phenotypic testing, state-of-the-art techniques for “deeper” phenotype assessment, as well as assistance to conduct well-controlled research interventions, all of which greatly enhance and expand on existing approaches used by researchers in the areas of nutrition and obesity in children and adults.