Epidemiology of Infectious Diseases

项目摘要 尽管在通过卫生、抗菌剂、疫苗和其他手段进行预防和治疗方面取得了进展 尽管采取了各种措施，传染病仍然威胁着生命和健康。2016年，传染病 占全球伤残调整寿命年损失的17%以上。在全球化的背景下， 传染病威胁(以前被视为仅限于欠发达国家)威胁 每个人(如埃博拉、艾滋病毒、MERS、大流行性流感和对抗菌剂日益增长的耐药性 毒品)。算力与大数据的结合提供了新的机遇 通过新的方法研究传染病及其传播，需要新的 加强对传染病流行病学家的培训。我们认识到有必要建立一个 学术和政府流行病学家团队，装备精良 基于MCMC的因果推断、传动动态建模、模型拟合方法 其他贝叶斯技术、种群基因组学、系统发育学和其他新技术。 哈佛大学陈冯富珍公共卫生学院(HSPH)跨学科项目的目标 传染病流行病学(IPIDE)是培养能够应用这些不同工具的毕业生 以应对新一代的传染病威胁。我们的培训人员包括领导 所有这些技术的实践者和我们最近的毕业生都在接受深度培训， 研究经验，以及其中许多领域的出版物。培训计划包括 IPIDE的流行病学、抗药性和疾病的数学模型课程 在我们25名教师导师的密切监督下，他们获得了学士学位或博士学位。一个 到目前为止，非常成功的博士后培训计划依赖于研究资金。 哈佛大学的IPIDE已经成功运行了20年，这笔培训赠款已经 帮助培养了一支新的学生干部队伍，能够监测、预防和 抑制各种新出现的传染病，但也允许IPIDE扩大其师资队伍， 资金，研究的多样性，以及加入传染病的学生数量 流行病学项目。十年来，资助学员23人，毕业学员18人， 他们发表了581篇同行评议的手稿(177篇第一作者出版物)。就目前而言 ，我们建议每年支持5名博士后和2名博士后实习生 下一个五年项目期。增加这些博士后职位将实现协同效应和 博士后和博士后研究员之间的合作机会，并创造机会 建立将博士后整合到高度跨学科的培训环境中的新方法。

Project Summary Despite progress in prevention and treatment by sanitation, antimicrobials, vaccines, and other measures, infectious diseases still threaten life and health. In 2016, communicable diseases accounted for over 17% of disability-adjusted life years lost worldwide. With globalization, infectious disease threats (previously seen as being limited to less-developed countries) threaten everyone (like Ebola, HIV, MERS, pandemic influenza, and growing resistance to antimicrobial drugs). The combination of computational power and “Big Data” provides a new opportunity to study infectious diseases and their transmission through novel approaches, necessitating new sophistication in the training of infectious disease epidemiologists. We recognize the need for a corps of academic and government epidemiologists, equipped to deploy sophisticated approaches to causal inference, transmission-dynamic modeling, model fitting using MCMC and other Bayesian techniques, population genomics, phylogenetics, and other novel techniques. The goal of Harvard Chan School of Public Health’s (HSPH) Interdisciplinary Program in Infectious Disease Epidemiology (IPIDE) is to train graduates who can apply these diverse tools to meet the infectious disease threats of a new generation. Our training faculty includes leading practitioners of all of these techniques and our recent graduates are emerging with deep training, research experience, and publications in many of these areas. The training program includes coursework in epidemiology, drug resistance, and mathematical modeling of disease from IPIDE under the close supervision of our 25 faculty mentors, leading either to a DSc or a PhD. A tremendously successful postdoctoral training program has to date relied on research funding. Harvard’s IPIDE has been running successfully for 20 years, and this training grant has helped develop not only a new cadre of students with the capacity to monitor, prevent, and suppress diverse emerging infectious diseases but has also allowed IPIDE to expand its faculty, funding, diversity of research, and, the number of students who join the infectious disease epidemiology program. Over the past ten years, 23 trainees have been supported, 18 graduated, and they published 581 peer-reviewed manuscripts (177 first author publications). For the current submission, we propose to support 5 pre-doc and 2 post-doctoral trainees each year over the next five-year project period. Adding these postdoctoral positions will realize synergies and collaborative opportunities between pre- and postdoctoral fellows and create the opportunity to build new means of integrating postdocs into the highly interdisciplinary training environment.