UT Southwestern NORC

UT 西南 NORC

• 批准号: 10657774
• 负责人: JAY D. HORTON
• 金额: $ 123万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657774
• 关键词: 3-Dimensional; Acceleration; Address; Animal Model; Animals; Award; Behavioral; Biochemical; Blood; Blood Pressure; Body Temperature; Budgets; Cardiovascular system; Cell Separation; Cells; Cessation of life; Clinical; Collaborations; Communication; DNA Sequencing Facility; Dementia; Development; Diabetes Mellitus; Digestive System Disorders; Direct Costs; Discipline; Disease; Doctor of Philosophy; Education; Elements; Endocrinology; Energy Metabolism; Extramural Activities; Faculty; Fatty acid glycerol esters; Funding; Gene Expression; Genetic; Glucose Clamp; Goals; Heart Rate; Homeostasis; Hormones; Human; Hyperinsulinism; Hypertension; Image; Individual; Inflammatory; Infrastructure; Interdisciplinary Study; Intervention; Lipids; Liver; Liver diseases; Malignant Neoplasms; Mass Spectrum Analysis; Measurement; Mentors; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolic syndrome; Metabolism; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Obesity associated cancer; Organ; Paper; Pathway interactions; Peripheral; Phenotype; Prevention strategy; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Risk; Scientist; Series; Services; Signal Transduction; Skeletal Muscle; Spectrum Analysis; Speed; Telemetry; Time; Tissues; Training; Translating; Translations; adipocyte biology; base; clinically relevant; disability; exome sequencing; imaging modality; improved; in vivo; innovation; member; next generation; non-alcoholic fatty liver disease; novel therapeutic intervention; nutrition; obesity treatment; post-doctoral training; programs; single cell sequencing; transcriptome sequencing; willingness

PROJECT SUMMARY/ABSTRACT – Overview: The overarching goal of the UTSW NORC is to enhance research efforts in nutrition and obesity by facilitating interdisciplinary interactions to speed translation of basic scientific discoveries into clinically relevant interventions in humans that improve public health. We have assembled a highly interactive and collaborative interdisciplinary team of investigators at UT Southwestern that harnesses expertise from diverse disciplines, with a goal of defining the behavioral, metabolic, genetic, and molecular mechanisms contributing to obesity and obesity-induced disease. The UTSW NORC research base consists of 158 investigators from 27 different Departments. These investigators have 230 extramurally funded nutrition/obesity-related research grants that total more than $74 million/yr in direct costs. To facilitate interdisciplinary research and the exchange of ideas, our NORC has created the following thematically related Teams: Team 1: Central Regulation of Energy Metabolism; Team 2: Adipocyte Biology and Energy Metabolism; Team 3: Obesity-induced Peripheral Organ Disease; and Team 4: Nutrition, Obesity, and Cancer. Within each team, we have integrated scientists from a wide spectrum of disciplines to comprehensively address the biochemical, metabolic, and clinical consequences of obesity and related diseases. Each Team has a mixture of senior, mid-level, and junior scientists, which will enhance the development of junior scientists and increase the likelihood of successful collaborations. The P&F program will support four new investigators/year who will also be assigned to one of the four research Teams. To support our research efforts, we have established four cores and a Clinical Element to provide state-of- the art services that exceed the capabilities, availability and/or budgets of individual NORC investigators. The Animal Phenotyping/Metabolism Core provides an extensive array of blood metabolites and hormones, 50+ metabolic cages, telemetry measurements of blood pressure, heart rate, core body temperature, and activity, multiple imaging modalities to characterize fat distribution, and hyperinsulinemic-euglycemic clamps and primary cell isolation. The Lipid Mass Spectrometry Core provides comprehensive quantification of lipids in cells, tissues, and blood. The Quantitative Metabolism and Imaging Core provides sophisticated flux measurements of metabolic pathways in vivo and 1H imaging and spectroscopy to characterize skeletal muscle and liver lipid content in humans. The Genetics, Single Cell Sequencing & RNA seq core provides exome sequencing and gene expression and analysis. All cores provide services for animal and human research, supporting the ability to translate findings more rapidly from animal models into testable hypothesis in humans. The UTSW NORC provides an important mechanism for a large group of diverse investigators to coalesce and focus their research efforts related to nutrition and obesity to accelerate translation of basic scientific discoveries into clinically relevant interventions in humans to improve public health.

项目总结/摘要-概述： UTSW NORC的首要目标是通过以下方式加强营养和肥胖方面的研究工作： 促进跨学科的互动，以加速将基础科学发现转化为临床相关的 对人类进行干预，以改善公共卫生。我们组织了一个高度互动和协作的 UT西南大学的跨学科研究团队，利用来自不同学科的专业知识， 其目标是确定导致肥胖的行为、代谢、遗传和分子机制 和肥胖引起的疾病。 UTSW NORC研究基地由来自27个不同部门的158名研究人员组成。这些 研究人员有230个额外资助的营养/肥胖相关的研究赠款，总额超过74美元， 亿元/年的直接成本。为了促进跨学科研究和思想交流，我们的NORC 创建了以下主题相关的团队：团队1：能量代谢的中央调节;团队2： 脂肪细胞生物学和能量代谢;第3组：肥胖诱导的外周器官疾病;第4组： 营养、肥胖和癌症。在每个团队中，我们都整合了来自各个领域的科学家， 学科，以全面解决肥胖的生化，代谢和临床后果， 相关疾病。每个团队都有高级，中级和初级科学家的混合，这将提高 培养年轻科学家，增加成功合作的可能性。P&F计划将 每年支持四名新的研究人员，他们也将被分配到四个研究小组之一。 为了支持我们的研究工作，我们已经建立了四个核心和一个临床元素，以提供国家的， 超出单个NORC研究者能力、可用性和/或预算的艺术服务。的 Animal Phenotyping/Metabolism Core提供广泛的血液代谢物和激素，50+ 代谢笼，血压、心率、核心体温和活动的遥测测量， 用于表征脂肪分布的多种成像模式，以及高胰岛素-正常血糖钳夹， 原代细胞分离。脂质质谱核心提供对脂质的全面量化 细胞组织和血液定量代谢和成像核心提供复杂的通量 体内代谢途径测量和表征骨骼肌的1H成像和光谱学 和人类肝脏脂质含量。遗传学，单细胞测序和RNA测序核心提供外显子组 测序和基因表达和分析。所有核心都为动物和人类研究提供服务， 支持将动物模型中的发现更快地转化为可在人类中验证的假设的能力。 UTSW NORC为一大群不同的研究人员提供了一个重要的机制， 并将他们的研究工作集中在营养和肥胖方面，以加速基础科学的转化， 在人类临床相关干预措施中的发现，以改善公共卫生。