Training in HIV Persistence, Co-morbidities and Therapeutics

艾滋病毒/艾滋病曾经是一种致命的疾病，肆虐许多社区，现在已成为一种致命的疾病。 有些是具有相关并发症的慢性疾病。同样，我们在破译方面取得的历史性研究成功 HIV基本发病机制现在必须针对有关消除HIV的新问题， 疫苗和治疗方法的开发，以及治疗和预防人类后续疾病的努力 战胜疾病。研究人员专注于这些问题，具有特定的技能和知识，有吸引力 需要采取多种职业道路来应对艾滋病毒/艾滋病疾病中的这些新挑战。整体 T32 的目标是培养博士生的知识、方法、分析和领导技能 成为未来成功的艾滋病毒研究人员。为了实现这些目标，我们将 (A) 提供强化 艾滋病毒/艾滋病研究的教学教育。将提供新的艾滋病毒持续性必修课程作为补充 核心教学研究课程。正在进行的研究将在受训者和专家之间共享 年度务虚会和选修课程目录将在三个方面提供建立艾滋病毒知识的机会 主要重点领域：(i) 治愈研究，包括 T 细胞疗法和逆转病毒潜伏期； (二) 共同 疾病，包括恶性肿瘤和中枢神经系统疾病； (iii) 预防研究，包括疫苗和新型药物 治疗学； (B) 每年招收两名优秀博士生，为期两年的支持活动 加速他们走向独立的进程。每个学员都会有一个个性化的项目，其特点是 a) 多导师团队协助设计和实施假设驱动的研究项目，b) a 建立艾滋病毒特定知识和研究技能的课程，c) 专业发展，包括 演讲技巧和资助写作 d) 广泛的接触机会，包括参与基于小组的实习 为艾滋病毒科学家提供多种职业道路的机会，以及强有力的计划监督； (C) 培养 当地基础设施和多部门合作文化，以支持艾滋病毒研究培训。这个 应用程序加入了来自 GW 多个院系和学校以及哥伦比亚特区中心的教师 艾滋病研究 (DC CFAR) 引入新观点和新想法，共同提供 在艾滋病毒研究的跨领域高优先领域开展出色的合作培训。加强跨校 和区域研究者的定位和网络，以及研究进展报告和会议是固有的 这个计划。将扩大加强导师发展的新方法并将其制度化，以加强 教师指导实践有效的自主支持指导。

HIV/AIDS once constituted a lethal diagnosis that ravaged many communities and has now become for some a chronic disease with associated co-morbidities. Likewise, our historic research successes in deciphering the mechanisms of fundamental HIV pathogenesis must now be directed to new questions about HIV elimination, vaccines and therapeutic development, and efforts to treat and prevent subsequent disorders among people surviving the disease. Researchers focused on these questions, with specific skillsets and knowledge, attractive to multiple career paths, are needed to address these emerging challenges in HIV/AIDS disease. The overall goal of this T32 is to prepare doctoral students with the knowledge, methodologic, analytic and leadership skills to become successful future HIV research investigators. To achieve these goals, we will (A) Provide intensive didactic education in HIV/AIDS research. A new required course in HIV Persistence will be offered to complement a core didactic research curriculum. Research in progress will be shared among trainees and experts at an annual retreat, and a catalog of elective courses will round out opportunities to build HIV knowledge in three major emphasis areas: (i) cure research, including T-cell therapy and the reversal of viral latency; (ii) co- morbidities, including malignancies and CNS disease; and (iii) prevention research, including vaccines and novel therapeutics; (B) Recruit two outstanding doctoral students per year for 2 years of support with activities to accelerate their progression to independence. Each trainee will have an individualized project characterized by a) multiple-mentor teams to aid in the design and implementation of hypothesis-driven research projects, b) a curriculum to build HIV specific knowledge and research skill sets, c) professional development including presentation skills and grant-writing d) strong exposure including participation in group-based externship opportunities in multiple career paths for HIV scientists, and strong programmatic oversight; and (C) Cultivate a local infrastructure and multi-departmental culture of collaboration to support HIV research training. This application joins faculty from multiple GW departments and schools, as well as the District of Columbia Center for AIDS Research (DC CFAR) to introduce new perspectives and fresh ideas that will collectively offer outstanding collaborative training in cross-cutting high priority areas of HIV research. Enhanced cross-school and regional investigator orientation and networks, and research progress reports and meetings are intrinsic to this plan. New approaches to enhance mentor development will be expanded and institutionalized to strengthen faculty mentoring practices in effective autonomy-supportive mentoring.