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Digital Therapeutic Development of Virtual Cognitive-Affective Training for Opioid Use Disorder

阿片类药物使用障碍虚拟认知情感训练的数字治疗开发

基本信息

批准号：
10255561
负责人：
RISA B WEISBERG
金额：
$ 31.9万
依托单位：
BEHAVR, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-15 至 2022-08-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10255561
关键词：
Abstinence Adherence Affect Affective American Area Under Curve Back Behavior Therapy Behavioral Biochemical Biometry Brain Buprenorphine COVID-19 pandemic Clinic Clinical Clinical Research Cloud Computing Cognitive Computerized Medical Record Custom Data Development Dropout Ecological momentary assessment Educational Intervention Electronic Health Record Environment Epidemic Fast Healthcare Interoperability Resources Feedback Funding Goals Health Services Accessibility Human Human Resources Individual Ingestion Intervention Light Link Machine Learning Measurement Measures Medical Device National Institute of Drug Abuse Opioid Outcome Participant Patients Pharmaceutical Preparations Phase Plant Roots Process Protocols documentation Psychophysiology Randomized Controlled Trials Records Recovery Regulatory Pathway Relapse Research Design Resources Rewards Risk Safety Self Efficacy Services Signal Transduction Small Business Innovation Research Grant Specific qualifier value Sum System Techniques Teleconferences Testing Therapeutic Effect Training Translating Treatment outcome United States United States Food and Drug Administration Viral addiction affective neuroscience arm barrier to care biobehavior chronic pain clinical efficacy commercialization craving cue reactivity design digital treatment effective intervention efficacy study electronic data evidence base experience implementation barriers improved innovation meetings mindfulness neurophysiology novel opioid epidemic opioid misuse opioid treatment program opioid use opioid use disorder patient engagement patient safety phase 1 study prescription opioid prevent programs promoter prototype response reward processing satisfaction skills success therapeutic development therapy development treatment as usual treatment program treatment risk treatment strategy usability virtual virtual machine virtual reality virtual reality system

项目摘要

Project Summary: The US is experiencing an opioid crisis, with an estimated 2.5 million Americans meeting full criteria for opioid use disorder (OUD). Medications for opioid use disorder (MOUD) like buprenorphine are currently the most effective form of intervention for OUD. In spite of the proven efficacy of MOUD, nearly half of people who begin a MOUD relapse within six months. As such, novel and efficacious behavioral adjuncts to MOUD are needed to improve treatment outcomes. Mindfulness-Oriented Recovery Enhancement (MORE), a cognitive-affective training intervention generated through a NIDA-funded treatment development process has shown significant promise, demonstrating therapeutic effects in four randomized controlled trials (RCTs) by reducing opioid use and misuse and modulating neurophysiological responses during drug cue-reactivity and natural reward processing. However, the MORE intervention requires significant human interaction and is therefore resource intensive. Further, in light of the COVID-19 pandemic, people with OUD may be reticent to engage in face-to-face interventions due to the risk of viral spread. To overcome these implementation barriers and increase access to treatment, the proposed project will develop and test a virtual reality version of the MORE intervention (MORE-VR) built on BehaVR LLC's VR existing, commercially available platform, the Dynamic eXperience Engine (DXE). The DXE uses machine learning to integrate biometrics into the VR experience to personalize addictions treatment, boosting patient engagement and optimizing the efficacy of clinical intervention. In Phase I, we will develop and test the MORE-VR prototype in a single arm clinical study of OUD patients receiving buprenorphine in an opioid treatment program (OTP), focusing on patient safety and engagement. If the prototype is perceived to have adequate usability and Net Promoter Scores, as well as to produce improvements in proximal measures of craving and affective state, the project will progress to Phase II. In Phase II, we will first develop the MORE-VR Minimal Viable Program using feedback from our Phase I study to optimize the intervention, and then conduct a RCT of MORE-VR vs. MOUD treatment as usual. Our robust and unbiased research design will triangulate clinical outcome measurement with biochemical verification of abstinence, ecological momentary assessments (EMA), and neurophysiological assessment of cue-reactivity. Further, we will integrate the MORE-VR Program into the OTP operational environment, building Fast Healthcare Interoperability Resources interfaces to ingest patient data from electronic medical records (EMRs) and to export patient utilization, assessment, and biometric data back to EMRs to create patient records and inform clinicians of patient progress. Activities in Phase I and Phase II will help define the regulatory pathway and establish regulatory feasibility to precede Food and Drug Administration (FDA) approval of the MORE-VR system as a Class II medical device. In sum, this project will translate an evidence- based biobehavioral treatment approach into an innovative digital therapeutic for OUD.

项目摘要：美国正在经历一场阿片类药物危机，估计有250万美国人在吸毒