Training in HIV Persistence, Co-morbidities and Therapeutics

HIV 持续性、合并症和治疗方面的培训

• 批准号: 10326881
• 负责人: Alberto Bosque
• 金额: $ 9.86万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10326881
• 关键词: HIV; Therapeutic; Training; comorbidity

HIV/AIDS once constituted a lethal diagnosis that ravaged many communities and has now become for some a chronic disease with associated co-morbidities. Likewise, our historic research successes in deciphering the mechanisms of fundamental HIV pathogenesis must now be directed to new questions about HIV elimination, vaccines and therapeutic development, and efforts to treat and prevent subsequent disorders among people surviving the disease. Researchers focused on these questions, with specific skillsets and knowledge, attractive to multiple career paths, are needed to address these emerging challenges in HIV/AIDS disease. The overall goal of this T32 is to prepare doctoral students with the knowledge, methodologic, analytic and leadership skills to become successful future HIV research investigators. To achieve these goals, we will (A) Provide intensive didactic education in HIV/AIDS research. A new required course in HIV Persistence will be offered to complement a core didactic research curriculum. Research in progress will be shared among trainees and experts at an annual retreat, and a catalog of elective courses will round out opportunities to build HIV knowledge in three major emphasis areas: (i) cure research, including T-cell therapy and the reversal of viral latency; (ii) co- morbidities, including malignancies and CNS disease; and (iii) prevention research, including vaccines and novel therapeutics; (B) Recruit two outstanding doctoral students per year for 2 years of support with activities to accelerate their progression to independence. Each trainee will have an individualized project characterized by a) multiple-mentor teams to aid in the design and implementation of hypothesis-driven research projects, b) a curriculum to build HIV specific knowledge and research skill sets, c) professional development including presentation skills and grant-writing d) strong exposure including participation in group-based externship opportunities in multiple career paths for HIV scientists, and strong programmatic oversight; and (C) Cultivate a local infrastructure and multi-departmental culture of collaboration to support HIV research training. This application joins faculty from multiple GW departments and schools, as well as the District of Columbia Center for AIDS Research (DC CFAR) to introduce new perspectives and fresh ideas that will collectively offer outstanding collaborative training in cross-cutting high priority areas of HIV research. Enhanced cross-school and regional investigator orientation and networks, and research progress reports and meetings are intrinsic to this plan. New approaches to enhance mentor development will be expanded and institutionalized to strengthen faculty mentoring practices in effective autonomy-supportive mentoring.

艾滋病毒/艾滋病曾经构成一种致命的诊断，它肆虐许多社区，现在已经成为 有些人是慢性疾病，并有相关的共病。同样，我们的历史研究在破译方面也取得了成功 HIV的基本致病机制现在必须指向关于消除HIV的新问题， 疫苗和治疗发展，以及治疗和预防人们随后的疾病的努力 在疾病中存活下来。研究人员专注于这些问题，具有特定的技能和知识，具有吸引力 要应对艾滋病毒/艾滋病方面的这些新挑战，就需要将职业道路扩展到多种职业道路。整体而言 这个T32的目标是培养博士生的知识，方法，分析和领导技能 成为未来成功的艾滋病毒研究调查人员。为了实现这些目标，我们将(A)提供密集的 艾滋病毒/艾滋病研究中的说教教育。将开设一门关于艾滋病毒持久性的新必修课，以补充 核心的教学研究课程。正在进行的研究将在学员和专家会议上分享 一年一度的静修和选修课程目录将在三年内提供建立艾滋病毒知识的机会 主要重点领域：(1)治愈研究，包括T细胞疗法和逆转病毒潜伏期；(2)共同 疾病，包括恶性肿瘤和中枢神经系统疾病；和(3)预防研究，包括疫苗和新技术 治疗学；(B)每年招收两名优秀博士生，为期两年，开展下列活动 加快他们走向独立的进程。每个学员都将有一个个性化的项目，其特点是 A)多名导师小组协助设计和实施假设驱动的研究项目，b)a 建立艾滋病毒专门知识和研究技能的课程，c)专业发展，包括 演示技巧和赠款撰写d)有很强的曝光率，包括参与基于团体的外部资助 艾滋病毒科学家在多种职业道路上的机会，以及强有力的方案监督；和(C)培养 地方基础设施和多部门协作文化，以支持艾滋病毒研究培训。这 应用程序加入了来自多个GW部门和学校以及哥伦比亚特区中心的教师 为艾滋病研究(DC CFAR)引入新的视角和新的想法，将共同提供 在艾滋病毒研究的交叉高度优先领域开展出色的协作培训。增强的跨校学习 以及区域调查员培训和网络，以及研究进展报告和会议是 这个计划。将扩大和制度化加强导师发展的新方法，以加强 教师辅导实践中有效的自主支持辅导。