Training in HIV Persistence, Co-morbidities and Therapeutics

HIV 持续性、合并症和治疗方面的培训

• 批准号: 10326881
• 负责人: Alberto Bosque
• 金额: $ 9.86万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10326881
• 关键词: HIV; Therapeutic; Training; comorbidity

HIV/AIDS once constituted a lethal diagnosis that ravaged many communities and has now become for some a chronic disease with associated co-morbidities. Likewise, our historic research successes in deciphering the mechanisms of fundamental HIV pathogenesis must now be directed to new questions about HIV elimination, vaccines and therapeutic development, and efforts to treat and prevent subsequent disorders among people surviving the disease. Researchers focused on these questions, with specific skillsets and knowledge, attractive to multiple career paths, are needed to address these emerging challenges in HIV/AIDS disease. The overall goal of this T32 is to prepare doctoral students with the knowledge, methodologic, analytic and leadership skills to become successful future HIV research investigators. To achieve these goals, we will (A) Provide intensive didactic education in HIV/AIDS research. A new required course in HIV Persistence will be offered to complement a core didactic research curriculum. Research in progress will be shared among trainees and experts at an annual retreat, and a catalog of elective courses will round out opportunities to build HIV knowledge in three major emphasis areas: (i) cure research, including T-cell therapy and the reversal of viral latency; (ii) co- morbidities, including malignancies and CNS disease; and (iii) prevention research, including vaccines and novel therapeutics; (B) Recruit two outstanding doctoral students per year for 2 years of support with activities to accelerate their progression to independence. Each trainee will have an individualized project characterized by a) multiple-mentor teams to aid in the design and implementation of hypothesis-driven research projects, b) a curriculum to build HIV specific knowledge and research skill sets, c) professional development including presentation skills and grant-writing d) strong exposure including participation in group-based externship opportunities in multiple career paths for HIV scientists, and strong programmatic oversight; and (C) Cultivate a local infrastructure and multi-departmental culture of collaboration to support HIV research training. This application joins faculty from multiple GW departments and schools, as well as the District of Columbia Center for AIDS Research (DC CFAR) to introduce new perspectives and fresh ideas that will collectively offer outstanding collaborative training in cross-cutting high priority areas of HIV research. Enhanced cross-school and regional investigator orientation and networks, and research progress reports and meetings are intrinsic to this plan. New approaches to enhance mentor development will be expanded and institutionalized to strengthen faculty mentoring practices in effective autonomy-supportive mentoring.

艾滋病毒/艾滋病曾经是一种致命的诊断，蹂躏了许多社区，现在已成为一种流行病。 有些是慢性病，伴有合并症。同样，我们在破译 HIV基本发病机制现在必须针对HIV消除的新问题， 疫苗和治疗方法的开发，以及治疗和预防人群中后续疾病的努力 在疾病中生存。研究人员专注于这些问题，具有特定的技能和知识，吸引人 为了应对艾滋病毒/艾滋病领域新出现的挑战，需要有多种职业道路。整体 这个T32的目标是准备博士生的知识，方法，分析和领导能力 成为未来成功的HIV研究者。为了实现这些目标，我们将（A）提供密集的 在艾滋病毒/艾滋病研究方面的教学教育。将开设一门新的艾滋病毒持久性必修课， 核心教学研究课程。正在进行的研究将在一次研讨会上由受训人员和专家分享， 每年的务虚会和选修课程目录将提供机会，建立艾滋病毒知识在三个 主要重点领域：（i）治疗研究，包括T细胞疗法和逆转病毒潜伏期;（ii）共同 发病率，包括恶性肿瘤和中枢神经系统疾病;和（iii）预防研究，包括疫苗和新的 （B）每年招收两名优秀博士生，为期2年， 加速他们走向独立。每个学员将有一个个性化的项目，其特点是 a）多导师团队，以帮助设计和实施假设驱动的研究项目，B）a 课程，以建立艾滋病毒的具体知识和研究技能，c）专业发展，包括 演讲技巧和撰写赠款d）广泛接触，包括参加以小组为基础的实习 为艾滋病毒科学家提供多种职业道路的机会，以及强有力的方案监督;以及（C）培养一个 地方基础设施和多部门合作文化，以支持艾滋病毒研究培训。这 申请加入教师从多个GW部门和学校，以及哥伦比亚特区中心 艾滋病研究（DC CFAR）引入新的观点和新的想法，将共同提供 在艾滋病毒研究的交叉高度优先领域进行了出色的合作培训。加强跨校 和区域研究者指导和网络，以及研究进展报告和会议， 这个计划将扩大促进导师发展的新办法并使之制度化， 教师指导实践中有效的支持性指导。