Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for sub-Saharan Africa (PARCA)

撒哈拉以南非洲儿童艾滋病毒/艾滋病和预防相关肿瘤研究联合会 （PARCA） 该提案的目标是建立PARCA，一个合作的临床和转化研究框架 其总体目标是改善艾滋病毒感染儿童目前令人无法接受的不良结果， 相关的恶性肿瘤在撒哈拉以南非洲（SSA）。目前，在美国，超过80%的癌症儿童 生存，而在大多数撒哈拉以南非洲国家超过80%的人死亡。为了开始解决这一差距， 在SSA，德克萨斯州儿童医院的癌症儿童的结果利用了临床基础设施， BIPAI在乌干达、马拉维和博茨瓦纳建立全球希望（血液肿瘤儿科 卓越）。Global HOPE致力于为全球癌症儿童提供卓越的护理和治疗 和血液疾病的治疗方法和尖端研究。全球三大希望 儿科癌症项目在全国范围内治疗患者，已经开始改变SSA的癌症护理。在 在美国，儿童癌症生存率的提高主要是通过临床和转化研究实现的 由儿童肿瘤学小组等合作小组协调。根据这个模型，我们建议 建立一个合作框架，使撒哈拉以南非洲感染艾滋病毒的儿童能够取得进展， 通过PARCA确诊为癌症 联合会的总体目标是： 1.定义SSA中与儿科恶性肿瘤相关的描述性流行病学和感染暴露。我们 将确定SSA中BIPAI网络中HIV相关恶性肿瘤的发病率和结局。 2.进行变革性的跨学科合作研究，以减轻KS和淋巴瘤的负担 儿童和青少年中。我们将建立多中心的诊断策略，风险- 分层和改善卡波西肉瘤和淋巴瘤患儿的预后。这些研究 最好在乌干达、马拉维和博茨瓦纳进行，因为那里的儿科患者人数很多 足以得出有意义的结果和结论。经验证的结果将在整个 我们的全球希望网络，因为它继续扩大在SSA的业务。 3.支持在临床和转化研究中形成跨国合作资源， 为非洲艾滋病毒和儿童癌症领域的科学领导人提供培训和职业发展。我们将提供 为整个SSA的儿科肿瘤学家提供无数的研究和培训机会， 领导转化和临床研究。这项科学训练计划将补充和补充 全球希望儿科血液学和肿瘤学奖学金计划的持续成功。

Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA) The goal of this proposal is to establish PARCA, a collaborative clinical and translational research framework designed with the overarching goal to improve the current unacceptably poor outcomes of children with HIV- associated malignancies in sub-Saharan Africa (SSA). Currently, over 80% of children with cancer in the US survive, whereas over 80% in the majority of SSA countries die. To begin to address this disparity and improve outcomes for children with cancer in SSA, Texas Children's Hospital leveraged the clinical infrastructure of BIPAI in Uganda, Malawi, and Botswana to establish Global HOPE (Hematology-Oncology Pediatric Excellence). Global HOPE is dedicated to excellence in the care and treatment of children globally with cancer and blood disorders through state-of-the-art treatments and cutting-edge research. These three Global HOPE pediatric cancer programs, which treat patients nationwide, have begun to transform cancer care in SSA. In the US, improvements in pediatric cancer survival were achieved largely through clinical and translational research coordinated by cooperative groups such as the Children's Oncology Group. Following that model, we propose to establish a framework for collaboration to enable advances for children in SSA living with HIV and diagnosed with cancer through PARCA. The Overarching Goals of the Consortium are to: 1. Define the descriptive epidemiology and infectious exposures related to pediatric malignancies in SSA. We will determine the incidence and outcomes of HIV-associated malignancy across the BIPAI network in SSA. 2. Conduct transformative inter-disciplinary collaborative research to reduce the burden of KS and lymphoma among children and adolescents in SSA. We will establish multi-center strategies for diagnosis, risk- stratification, and outcomes improvement for children with Kaposi sarcoma and lymphoma. These studies will be best conducted in Uganda, Malawi, and Botswana, where the pediatric patient population is large enough to establish meaningful results and conclusions. Validated results will be disseminated throughout our Global HOPE network, as it continues to expand operations in SSA. 3. Support the formation of a multi-national collaborative resource in clinical and translational research, training, and career development for African scientific leaders in HIV and pediatric cancer. We will provide myriad research and training opportunities for pediatric oncologists throughout SSA to participate in and lead translational and clinical research. This program of scientific training will complement and supplement the continued success of Global HOPE Paediatric Haematology and Oncology Fellowship Program.