课题基金 / 基金详情

Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure

Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
严格评估间日疟原虫复发和伯氨喹根治疗效
批准号:
10657543
负责人:
David Serre
金额:
$57.47万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-07-17 至 2025-06-30

项目摘要

项目成果

David Serre的其他基金

相似基金

相关文献

中文摘要
翻译
间日疟原虫威胁着世界上一半的人口。虽然正在进行的消灭疟疾的努力是 虽然成功地减少了全球恶性疟疾的负担,但P. 间日疟原虫特别是间日疟原虫在肝脏中保持休眠并导致复发的独特能力 感染数周或数月后,疟疾消除运动变得非常复杂。在这里,我们建议进行 在柬埔寨进行严格控制的实地研究,专门用于支持和授权最先进的 基因组分析,以确定复发的频率和与催眠子再激活相关的因素, 以及严格评估不同剂量伯氨喹用于根治治疗的功效。我们 研究将为间日疟原虫复发提供一个独特的视角,并将有助于更好地了解如何 成功地消灭了这种未被充分研究的寄生虫
英文摘要
Plasmodium vivax threatens half of the world’s population. While on-going malaria elimination efforts are successfully reducing the burden of falciparum malaria worldwide, the situation is much less promising for P. vivax. In particular, the unique ability of P. vivax parasites to remain dormant in the liver and cause relapse infections weeks or months later greatly complicates malaria elimination campaigns. Here we propose to conduct a tightly-controlled field study in Cambodia, specifically designed to support and empower state-of-the-art genomic analyses, to determine the frequency of relapse and the factors associated with hypnozoite reactivation, as well as to rigorously evaluate the efficacy of different doses of primaquine for radical cure treatment. Our studies will provide a unique perspective on P. vivax relapse and will contribute to better understand how to successfully eliminate this understudied parasite.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.ijpddr.2020.12.004
发表时间: 2021-04
期刊: International journal for parasitology. Drugs and drug resistance
影响因子: --
作者: [Popovici J, Tebben K, Witkowski B, Serre D]
通讯作者: Serre D
Host and parasite factors influencing P. vivax RBC invasion and asexual development
  • 批准号:
    10641026
  • 项目类别:
  • 资助金额:
    $70.63万
  • 财政年份:
    2022
  • 负责人:
    David Serre
  • 依托单位:
Multi-Omics Characterization of Plasmodium Vivax Hypnozoites
  • 批准号:
    10565802
  • 项目类别:
  • 资助金额:
    $72.51万
  • 财政年份:
    2022
  • 负责人:
    David Serre
  • 依托单位:
Design and Evaluation of a Plasmodium vivax ultra-dense peptide array
  • 批准号:
    10372166
  • 项目类别:
  • 资助金额:
    $23.18万
  • 财政年份:
    2021
  • 负责人:
    David Serre
  • 依托单位:
Design and Evaluation of a Plasmodium vivax ultra-dense peptide array
  • 批准号:
    10189044
  • 项目类别:
  • 资助金额:
    $19.31万
  • 财政年份:
    2021
  • 负责人:
    David Serre
  • 依托单位:
海外基金