Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
批准号:
10657543
负责人:
David Serre
金额:
$57.47万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-07-17 至 2025-06-30
关键词:
AddressAdherenceAfricaAllelesAreaBiologyBloodBlood specimenCYP2D6 geneCambodiaChloroguanideCollaborationsCollectionCountryDetectionDevelopmentDoseDrug KineticsEnrollmentErythropoiesisFalciparum MalariaFingersFrequenciesGene ExpressionGenesGenetic PolymorphismGenomeGenomic approachGenomicsGenotypeGlucosephosphate Dehydrogenase DeficiencyHumanIn VitroIncidenceIndividualInfectionInflammationLaboratoriesLiverMalariaMetabolismModernizationMorbidity - disease rateParasitesPatientsPatternPersonsPharmaceutical PreparationsPlasmodium falciparumPlasmodium vivaxPopulationPredispositionPrimaquinePrimary InfectionProteinsProxyRecommendationRecrudescencesRecurrenceRegimenRelapseRetreatmentSepsisSerologySporozoitesTestingTimeVariantVivax MalariaWorkatovaquoneclinically relevantdesigneconomic impactefficacy evaluationempowermentfield studygenome sequencingimprovedinsightpatient subsetsresponseside effecttransmission processwhole genome
中文摘要
间日疟原虫威胁着世界上一半的人口。虽然正在进行的消除疟疾工作是
成功地减轻了全球恶性疟疾的负担,但对P.
间日疟原虫。尤其是间日疟原虫在肝脏中休眠并导致复发的独特能力
几周或几个月后的感染极大地使消除疟疾的运动复杂化。在这里,我们建议进行
在柬埔寨严格控制的实地研究,专门为支持和支持最先进的技术而设计
基因组分析,以确定复发的频率和与催产素重新激活相关的因素,
以及严格评估不同剂量伯喹根治的疗效。我们的
研究将为间日疟原虫复发提供一个独特的视角,并有助于更好地了解如何
成功消灭了这种未被研究的寄生虫。
英文摘要
Plasmodium vivax threatens half of the world’s population. While on-going malaria elimination efforts are
successfully reducing the burden of falciparum malaria worldwide, the situation is much less promising for P.
vivax. In particular, the unique ability of P. vivax parasites to remain dormant in the liver and cause relapse
infections weeks or months later greatly complicates malaria elimination campaigns. Here we propose to conduct
a tightly-controlled field study in Cambodia, specifically designed to support and empower state-of-the-art
genomic analyses, to determine the frequency of relapse and the factors associated with hypnozoite reactivation,
as well as to rigorously evaluate the efficacy of different doses of primaquine for radical cure treatment. Our
studies will provide a unique perspective on P. vivax relapse and will contribute to better understand how to
successfully eliminate this understudied parasite.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.ijpddr.2020.12.004
发表时间:
2021-04
期刊:
International journal for parasitology. Drugs and drug resistance
影响因子:
--
作者:
[Popovici J, Tebben K, Witkowski B, Serre D]
通讯作者:
Serre D
Host and parasite factors influencing P. vivax RBC invasion and asexual development
-
批准号:10641026
-
项目类别:
-
资助金额:$70.63万
-
财政年份:2022
-
负责人:David Serre
-
依托单位:
Multi-Omics Characterization of Plasmodium Vivax Hypnozoites
-
批准号:10565802
-
项目类别:
-
资助金额:$72.51万
-
财政年份:2022
-
负责人:David Serre
-
依托单位:
Design and Evaluation of a Plasmodium vivax ultra-dense peptide array
-
批准号:10372166
-
项目类别:
-
资助金额:$23.18万
-
财政年份:2021
-
负责人:David Serre
-
依托单位:
Design and Evaluation of a Plasmodium vivax ultra-dense peptide array
-
批准号:10189044
-
项目类别:
-
资助金额:$19.31万
-
财政年份:2021
-
负责人:David Serre
-
依托单位:
Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
-
批准号:10469663
-
项目类别:
-
资助金额:$64.43万
-
财政年份:2020
-
负责人:David Serre
-
依托单位:
Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure
-
批准号:10219069
-
项目类别:
-
资助金额:$63.96万
-
财政年份:2020
-
负责人:David Serre
-
依托单位:
Host and Parasite Transcriptional Changes Associated with Immunity to Clinical Malaria in Malian Children
-
批准号:9812115
-
项目类别:
-
资助金额:$23.18万
-
财政年份:2019
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:9254424
-
项目类别:
-
资助金额:$35.5万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:9398175
-
项目类别:
-
资助金额:$8.81万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:8576980
-
项目类别:
-
资助金额:$34.0万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:9056984
-
项目类别:
-
资助金额:$26.6万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:8660615
-
项目类别:
-
资助金额:$35.87万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in Cambodia
-
批准号:8839198
-
项目类别:
-
资助金额:$35.8万
-
财政年份:2013
-
负责人:David Serre
-
依托单位:
Molecular Basis and Consequences of Early Developmental Epigenetic Programming
-
批准号:8598470
-
项目类别:
-
资助金额:$34.15万
-
财政年份:2011
-
负责人:David Serre
-
依托单位:
Molecular Basis and Consequences of Early Developmental Epigenetic Programming
-
批准号:8387024
-
项目类别:
-
资助金额:$32.95万
-
财政年份:2011
-
负责人:David Serre
-
依托单位:
Molecular Basis and Consequences of Early Developmental Epigenetic Programming
-
批准号:8049656
-
项目类别:
-
资助金额:$39.25万
-
财政年份:2011
-
负责人:David Serre
-
依托单位:
Molecular Basis and Consequences of Early Developmental Epigenetic Programming
-
批准号:8210820
-
项目类别:
-
资助金额:$34.15万
-
财政年份:2011
-
负责人:David Serre
-
依托单位:
海外基金