Host and parasite factors influencing P. vivax RBC invasion and asexual development

影响间日疟原虫红细胞侵袭和无性发育的宿主和寄生虫因素

• 批准号: 10641026
• 负责人: David Serre
• 金额: $ 70.63万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-08 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641026
• 关键词: Antibodies; Antigens; Area; Binding; Biology; Blood; Blood specimen; Cambodia; Cambodian; Cell Cycle Progression; Cell physiology; Cell surface; Cells; Cellular Indexing of Transcriptomes and Epitopes by Sequencing; Characteristics; Collaborations; Complement; DNA; Data; Development; Erythrocytes; Exposure to; Foundations; G6PD gene; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic Polymorphism; Genomic approach; Genotype; Geographic Distribution; Glucosephosphate Dehydrogenase Deficiency; Growth; Hemoglobin; Hemoglobinopathies; Human; Immune; Immunity; In Vitro; Individual; Infection; Inflammation; Invaded; Leukocytes; Malaria; Malaria Vaccines; Measures; Molecular; Parasitemia; Parasites; Participant; Pathway interactions; Patients; Peripheral Blood Mononuclear Cell; Phenotype; Plasmodium; Plasmodium vivax; Population; Predisposition; Process; Proteins; RNA; Regulation; Role; Sampling; Serology; Severity of illness; Sex Differentiation; Solid; Symptoms; Testing; Transcriptional Regulation; Variant; Vivax Malaria; Whole Blood; acquired immunity; asexual; clinically relevant; cytokine; density; experience; experimental study; genome-wide; human pathogen; improved; in vivo; insight; novel; parasite invasion; patient subsets; prevent; resilience; response; single-cell RNA sequencing; transcriptome; transcriptome sequencing; transcriptomics; vaccine trial

Abstract Plasmodium vivax threatens half of the world’s population and is surprisingly resilient to on-going malaria elimination efforts, partially due to its unique characteristics and our poor understanding of its biology. Here, we propose to conduct state-of-the-art transcriptomic analyses using materials derived directly from Cambodian patients to rigorously assess the importance of red blood cell polymorphisms, host immunity and parasite factors in modulating the efficacy of red blood cell invasion and P. vivax intraerythrocytic development. Our studies will not only provide a better understanding of the fundamental molecular and cellular processes underlying blood stage P. vivax infections but will also provide a solid foundation to develop better malaria vaccines against this important but understudied human pathogen.

摘要