A Comparison of the Efficacy of Transdiagnostic Behavior Therapy and Disorder-specific Therapy in Veterans with PTSD, Anxiety, and Depression
跨诊断行为疗法和疾病特异性疗法对患有 PTSD、焦虑和抑郁的退伍军人的疗效比较
基本信息
- 批准号:10657498
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAftercareAgoraphobiaAnxietyAnxiety DisordersAppointmentAreaBehavior DisordersBehavior TherapyBehavioralClient satisfactionClinicalCognitiveCognitive TherapyCompetenceConsent FormsDiagnosisDiagnosticDiseaseDissemination and ImplementationEquipment and supply inventoriesFinancial HardshipFundingGoalsHealthcareImpairmentIndividualInformed ConsentIntakeInterventionInvestigationK-Series Research Career ProgramsMajor Depressive DisorderMeasuresMental DepressionMental disordersOutcomePanic DisorderParticipantPatient Self-ReportPopulationPost-Traumatic Stress DisordersProceduresProcessProtocols documentationProviderPsychiatric DiagnosisPsychotherapyQuestionnairesRandomizedRandomized, Controlled TrialsRecoveryRelapseResearchSamplingSeveritiesSymptomsTestingTimeTrainingTreatment ProtocolsUnited States Department of Veterans AffairsUnnecessary ProceduresVeteransacceptability and feasibilityanxiety symptomsassociated symptomcomorbiditycomparison groupcostcost effectivedepressive symptomsdesigndiagnostic strategyeffective therapyefficacious treatmentefficacy evaluationfollow-upimprovedinclusion criteriainnovationpsychiatric comorbiditysatisfactionsymptomatologytraittreatment comparisontreatment effecttrial comparingtrial designwillingness
项目摘要
Relevance of Research Plan: One priority area for the Department of Veterans Affairs (DVA) is
to provide quick, effective, recovery-oriented treatments for depressive/anxiety disorders,
representing the most common and impairing psychiatric disorders in Veterans. Cognitive
behavioral therapy (CBT) has demonstrated reliable efficacy in treating depressive/anxiety
disorders and their related impairments. However, CBT is underutilized due in large part to the
complexity and number of disorder-specific treatments (DSTs) protocols across disorders, as
well as extensive training needed to apply them to different diagnoses and different
combinations of diagnostic comorbidities. Recently, Transdiagnostic Behavior Therapy (TBT)
was developed as a transdiagnostic intervention to address each of the depressive/anxiety
disorders and their comorbidities in Veterans within a single treatment protocol. Initial studies of
TBT, including a funded CSR&D Career Development Award (CDA), demonstrate that the
treatment is efficacious in reducing psychiatric symptomatology and related impairments in
Veterans presenting with a wide range of diagnoses. Preliminary findings also support the ease
of dissemination and implementation of TBT by DVA providers. Although additional study is
needed with larger samples and improved comparison groups, the transdiagnostic approach in
TBT may address many of the current limitations of the DSTs discussed above. Primary Aims
in Research Plan: The proposed study aims to test the non-inferiority of TBT and DSTs in
improving psychiatric symptomatology and related impairments. It is hypothesized that TBT will
result non-inferior improvements in psychiatric symptomatology and related impairments
compared to the DST comparison groups. A secondary aim is to compare the feasibility and
acceptability of TBT and DSTs. Participant population: The participants of the proposed study
will include 216 Veterans with posttraumatic stress disorder (PTSD), major depressive disorder
(MDD), and/or panic disorder and agoraphobia (PD/AG). General inclusion criteria involve: 1) a
diagnosis of a PTSD, MDD, or PD/AG; and 2) a willingness and competence to provide
informed consent for research participation. Procedures to be used: A randomized controlled
trial (RCT) with TBT and DSTs conditions will be completed. Participation in the RCT will involve
completion of: 1) consent documentation, 2) intake assessment, 3) random assignment to
treatment condition, 4) weekly 45-60-minute appointments of psychotherapy for 12 weeks, and
5) self-report assessments of psychiatric symptomatology and impairment at intake, mid-
treatment, post-treatment, and 6-month follow-up. Process variables also will be investigated.
Anticipated Impacts on Veterans Health Care: Upon investigation with supported efficacy
and non-inferiority as compared to DSTs, TBT will represent an excellent treatment option within
the DVA in terms of providing a single protocol that is easy to disseminate to and implement by
providers as well as being efficacious in addressing psychiatric symptomatology and related
impairments in Veterans with various depressive/anxiety disorders and related comorbidities.
研究计划的相关性:退伍军人事务部 (DVA) 的一个优先领域是
为抑郁/焦虑症提供快速、有效、以康复为导向的治疗方法,
代表退伍军人中最常见和最有害的精神疾病。认知的
行为疗法(CBT)在治疗抑郁/焦虑方面已被证明具有可靠的功效
疾病及其相关损伤。然而,CBT 并未得到充分利用,这在很大程度上是由于
跨疾病的疾病特异性治疗 (DST) 方案的复杂性和数量,如
以及将它们应用于不同的诊断和不同的情况所需的广泛培训
诊断合并症的组合。最近,跨诊断行为疗法(TBT)
被开发为一种跨诊断干预措施,以解决每一种抑郁/焦虑问题
在单一治疗方案中解决退伍军人的疾病及其合并症。初步研究
TBT,包括资助的 CSR&D 职业发展奖 (CDA),表明
治疗可有效减少精神症状和相关损伤
退伍军人提出了各种各样的诊断。初步调查结果也支持轻松
DVA 提供商传播和实施 TBT 的情况。虽然额外的研究是
需要更大的样本和改进的比较组,跨诊断方法
TBT 可以解决上述 DST 当前的许多限制。主要目标
研究计划中:拟议的研究旨在测试 TBT 和 DST 的非劣效性
改善精神症状和相关障碍。据推测,TBT 将
导致精神症状和相关损伤的非劣质改善
与 DST 对照组相比。第二个目的是比较可行性和
TBT 和 DST 的可接受性。参与者人群:拟议研究的参与者
将包括 216 名患有创伤后应激障碍 (PTSD)、重度抑郁症的退伍军人
(MDD),和/或恐慌症和广场恐惧症 (PD/AG)。一般纳入标准包括: 1) a
PTSD、MDD 或 PD/AG 的诊断; 2) 提供的意愿和能力
研究参与的知情同意。使用的程序:随机对照
具有TBT和DST条件的试验(RCT)将完成。参与 RCT 将涉及
完成:1) 同意文件,2) 摄入评估,3) 随机分配
治疗条件,4) 每周 45-60 分钟的心理治疗预约,持续 12 周,以及
5)自我报告的精神症状学评估和摄入时的损伤,中期
治疗、治疗后和6个月的随访。还将调查过程变量。
对退伍军人医疗保健的预期影响:经调查并得到支持的功效
与 DST 相比,TBT 具有非劣效性,将代表一种极好的治疗选择
DVA 提供易于传播和实施的单一协议
提供者以及有效解决精神病症状和相关问题
患有各种抑郁/焦虑症和相关合并症的退伍军人的损伤。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel F. Gros其他文献
Erratum to: Influence of Depression on State and Trait Anger in Veterans with Posttraumatic Stress Disorder
- DOI:
10.1007/s10608-013-9534-3 - 发表时间:
2013-03-22 - 期刊:
- 影响因子:2.000
- 作者:
Phillip A. Raab;Margaret-Anne Mackintosh;Daniel F. Gros;Leslie A. Morland - 通讯作者:
Leslie A. Morland
Role of Atypical Antipsychotics in the Treatment of Generalized Anxiety Disorder
- DOI:
10.1007/s40263-014-0162-6 - 发表时间:
2014-05-05 - 期刊:
- 影响因子:7.400
- 作者:
Rachel Hershenberg;Daniel F. Gros;Olga Brawman-Mintzer - 通讯作者:
Olga Brawman-Mintzer
Daniel F. Gros的其他文献
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{{ truncateString('Daniel F. Gros', 18)}}的其他基金
A Randomized Clinical Trial Comparing Transdiagnostic Behavior Therapy to Disorder-Specific Psychotherapy in the Recovery of Veterans with Social Anxiety Disorder and Comorbid PTSD Symptomatology
一项随机临床试验,比较跨诊断行为疗法与特定障碍心理疗法在患有社交焦虑症和共病 PTSD 症状的退伍军人康复中的作用
- 批准号:
10746930 - 财政年份:2023
- 资助金额:
-- - 项目类别:
A Comparison of the Efficacy of Transdiagnostic Behavior Therapy and Disorder-specific Therapy in Veterans with PTSD, Anxiety, and Depression
跨诊断行为疗法和疾病特异性疗法对患有 PTSD、焦虑和抑郁的退伍军人的疗效比较
- 批准号:
10425235 - 财政年份:2020
- 资助金额:
-- - 项目类别:
A Comparison of the Efficacy of Transdiagnostic Behavior Therapy and Disorder-specific Therapy in Veterans with PTSD, Anxiety, and Depression
跨诊断行为疗法和疾病特异性疗法对患有 PTSD、焦虑和抑郁的退伍军人的疗效比较
- 批准号:
9884857 - 财政年份:2020
- 资助金额:
-- - 项目类别:
A Comparison of Group Transdiagnostic Behavior Therapy (G-TBT) to Disorder-Specific Group Psychotherapies in the Recovery of Veterans with PTSD, Major Depression, and Related Conditions
团体跨诊断行为疗法 (G-TBT) 与特定障碍团体心理疗法在患有 PTSD、重度抑郁症和相关病症的退伍军人康复中的比较
- 批准号:
10237899 - 财政年份:2019
- 资助金额:
-- - 项目类别:
A Comparison of Group Transdiagnostic Behavior Therapy (G-TBT) to Disorder-Specific Group Psychotherapies in the Recovery of Veterans with PTSD, Major Depression, and Related Conditions
团体跨诊断行为疗法 (G-TBT) 与特定障碍团体心理疗法在患有 PTSD、重度抑郁症和相关病症的退伍军人康复中的比较
- 批准号:
10000778 - 财政年份:2019
- 资助金额:
-- - 项目类别:
A Comparison of Group Transdiagnostic Behavior Therapy (G-TBT) to Disorder-Specific Group Psychotherapies in the Recovery of Veterans with PTSD, Major Depression, and Related Conditions
团体跨诊断行为疗法 (G-TBT) 与特定障碍团体心理疗法在患有 PTSD、重度抑郁症和相关病症的退伍军人康复中的比较
- 批准号:
10844353 - 财政年份:2019
- 资助金额:
-- - 项目类别:
A Comparison of Group Transdiagnostic Behavior Therapy (G-TBT) to Disorder-Specific Group Psychotherapies in the Recovery of Veterans with PTSD, Major Depression, and Related Conditions
团体跨诊断行为疗法 (G-TBT) 与特定障碍团体心理疗法在患有 PTSD、重度抑郁症和相关病症的退伍军人康复中的比较
- 批准号:
10508493 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Transdiagnostic Psychotherapy for Veterans with Mood and Anxiety Disorders
对患有情绪和焦虑症的退伍军人进行跨诊断心理治疗
- 批准号:
8813485 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Transdiagnostic Psychotherapy for Veterans with Mood and Anxiety Disorders
对患有情绪和焦虑症的退伍军人进行跨诊断心理治疗
- 批准号:
8967180 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Transdiagnostic Psychotherapy for Veterans with Mood and Anxiety Disorders
对患有情绪和焦虑症的退伍军人进行跨诊断心理治疗
- 批准号:
9242553 - 财政年份:2014
- 资助金额:
-- - 项目类别:
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