The role of prestimulus oscillatory brain dynamics in auditory memory

刺激前振荡脑动力学在听觉记忆中的作用

• 批准号: 10657762
• 负责人: Matthew G. Wisniewski
• 金额: $ 21.22万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657762
• 关键词: Area; Auditory; Auditory area; Brain; Cognitive; Communication; Complex; Computer Models; Data; Data Correlations; Dependence; Development; Devices; Discrimination; Disparate; Electroencephalography; Electrophysiology (science); Event; Exposure to; Frequencies; Goals; Head; Health; Human; Individual; Judgment; Knowledge; Language; Learning; Left; Linguistics; Link; Location; Magnetic Resonance Imaging; Measures; Memory; Memory Disorders; Methodology; Methods; Modeling; Neurobiology; Neuronal Plasticity; Neurosciences; Outcome; Perception; Performance; Periodicity; Phase; Play; Protocols documentation; Published Comment; Rehabilitation therapy; Research; Role; Scalp structure; Self-Help Devices; Sensory; Short-Term Memory; Source; Stimulus; Synaptic plasticity; System; Techniques; Testing; Time; Visual; Work; cognitive neuroscience; density; falls; independent component analysis; indexing; innovation; insight; long term memory; member; memory process; memory retrieval; neural; neuroinformatics; neuroregulation; repetitive transcranial magnetic stimulation; response; sound; stem; theories

PROJECT SUMMARY: WISNIEWSKI PROJECT Ongoing brain dynamics impact memory for events as they occur. This is evident in nonhuman and human neuroelectromagnetic recordings (e.g., electroencephalography - EEG) where prestimulus oscillatory brain states have been shown to determine neural plasticity and predict later memory retrieval. However, a reliance on correlational data, restrictive memory paradigms, outdated analysis techniques, and a bias to use visual and/or language stimuli has left open questions in the state of knowledge. It is still not clear whether prestimulus brain states causally impact memory, whether their impacts are related to the cortical source of oscillatory activity, and whether effects only apply to a subset of tasks. This makes it difficult to develop approaches that use prestimulus brain dynamics with health-relevant goals (e.g., systems that induce brain dynamics that can facilitate memory). The proposed research employs innovative methodological approaches to examine the central hypothesis that oscillatory prestimulus brain dynamics impact memory for sound. The data produced will fill gaps in the state of knowledge and identify directions that can be taken to exploit prestimulus brain dynamics to produce positive health outcomes. Aim 1 will determine how prestimulus oscillatory EEG dynamics relate to auditory memory performance. High-density (104 channel) EEG will be recorded while subjects encode sounds in memory tasks with the capability of assessing memory accuracy and precision. Analyses will reveal the prestimulus EEG oscillatory dynamics that are predictive of these memory performance metrics. Source modeling will reveal the cortical areas responsible for these effects and allow a characterization of how interactions among different sources influence memory. Aim 2 will modulate prestimulus brain dynamics and measure resulting impacts on memory. Both a sensory entrainment and repetitive transcranial magnetic stimulation (rTMS) protocol will be used to induce oscillatory brain states in subjects. Because brain states will be purposefully manipulated, this will provide a causal viewpoint on prestimulus oscillatory activity regarding memory performance. This project stands to produce theoretical insights on the functional roles of oscillatory brain activity in memory processes. For instance, it is directly relevant to theory on alpha (~8-13 Hz) oscillations which proposes that the phase and power of ongoing alpha should gate the processing of incoming events. Methods that allow causal inference will inform the ongoing debate in neuroscience as to whether oscillations play a functional role in processing or are merely epiphenomenal. Through its use of multiple methods (EEG, sensory entrainment, rTMS), the project also stands to identify the most useful directions to take in the development of rehabilitative/assistive devices. The project will link with all three of CNAP Phase 2 crosscutting themes (The Neurobiology of Learning and Memory, Neuromodulation and Assessment, and Advanced Computational Modeling) and will rely on the Neuroinformatics and Cognitive Neuroscience Cores.

项目概要：WISNIEWSKI项目 持续的大脑动力学影响事件发生时的记忆。这一点在非人类和人类身上都很明显。 神经电磁记录（例如，脑电图（EEG），其中刺激前振荡脑 状态已被证明可以决定神经可塑性并预测以后的记忆提取。然而，一种依赖 相关数据，限制性记忆范式，过时的分析技术，以及使用视觉的偏见 和/或语言刺激在知识状态中留下了开放的问题。目前尚不清楚是否 刺激前脑状态因果影响记忆，无论其影响是否与皮质源有关， 振荡活动，以及影响是否只适用于一个子集的任务。这使得开发难度加大 使用具有健康相关目标的刺激前脑动力学的方法（例如，诱导大脑的系统 可以促进记忆的动力学）。拟议的研究采用了创新的方法 研究振荡性刺激前脑动力学影响声音记忆的中心假设。的 所产生的数据将填补知识状态的空白，并确定可以利用的方向 prestimulus脑动力学产生积极的健康结果。Aim 1将决定预刺激如何 振荡EEG动力学与听觉记忆性能有关。高密度（104通道）EEG将被 记录，而受试者编码的声音在记忆任务的能力，评估记忆的准确性 和精确度。分析将揭示这些预测的刺激前EEG振荡动力学 内存性能指标。源模型将揭示负责这些影响的皮层区域， 允许表征不同来源之间的相互作用如何影响记忆。目标2将调节 刺激前脑动力学并测量对记忆的影响。既有感官上的吸引， 重复经颅磁刺激（rTMS）协议将用于诱导振荡脑状态， 科目由于大脑状态将被有目的地操纵，这将提供一个因果观点， 关于记忆表现的前刺激振荡活动。这个项目将产生理论上的 关于振荡脑活动在记忆过程中的功能作用的见解。例如，它直接 与α（~8 - 13 Hz）振荡理论相关，该理论提出，持续的α振荡的相位和功率 应该门控传入事件的处理。允许因果推理的方法将为正在进行的 神经科学中关于振荡在处理过程中是否起作用的争论 副现象通过使用多种方法（EEG，感觉夹带，rTMS），该项目还 旨在找出发展康复/辅助器具的最有用方向。的 该项目将与CNAP第二阶段的所有三个横向主题（学习的神经生物学和 记忆，神经调节和评估，以及高级计算建模），并将依赖于 神经信息学和认知神经科学核心。