Cognitive and Neurobiological Approaches to Plasticity (CNAP) Center Phase 2

项目概要：总体 第二阶段COBRE应用的目标是继续开发一个独特的，国家认可的， 主题研究中心的认知和神经生物学方法的可塑性（CNAP）。我们将建立在 通过进一步加强研究基础设施和继续建立足够数量的 研究认知和神经可塑性的科学家。我们将继续开发可塑性专题重点 该中心通过支持三个新的交叉主题领域的研究：学习的神经生物学 和记忆，神经调节和评估，以及高级计算建模。贯穿各领域 主题跨越动物模型和人类转化研究，并跨越学科。十字架- 切割主题反映了研究核心的计划增强，将当前的项目结合在一起， 指导教师招聘和未来试点赠款和替代项目赠款选择的优先事项，并将 为未来的项目开发提供信息。进一步发展CNAP中心及其相关的 计划将推动我们实现我们的目标，改善认知和神经功能，无论是健康的 人群和患有特定疾病或病症的个体。CNAP中心的发展将得到推进 通过实现四个具体目标：（1）促进CNAP项目和试点的R 01奖励成功 格兰特领袖在第二阶段，我们将支持三个新的研究项目负责人，他们有很强的潜力， 过渡到R 01级支持。此外，在我们的积极试点赠款计划在第一阶段取得成功后， 我们将继续在第二至第五年每年资助试点赠款，为毕业生提供更多的机会。 初级研究员到R 01级研究支持。(2)继续培养大量研究人员， 认知/神经可塑性通过招募新的CNAP成员。我们将招募三名新的终身教职人员 教师在研究领域有关的CNAP交叉主题。我们将进一步扩大CNAP 通过资助新的试点赠款和扩大研究核心，扩大成员资格。(3)为了进一步改进研究 通过扩大三个多用户核心实验室设施，加强基础设施。我们将扩大行为 神经科学核心，认知神经科学核心和神经信息学核心，增加了重要的新 促进获得现代神经科学和计算建模技术的能力。(4)到 通过加强科学交流，提高CNAP中心成员的研究能力 网络（SEN）。SEN将为CNAP研究人员提供额外的核心设施和培训， 提高他们获得校外资金的能力。实现这些目标将进一步推动蓬勃发展 专题研究中心，将增加认知和可塑性的神经机制的理解。 CNAP将通过个人研究者和伙伴关系赠款吸引校外资金， 促进研究人员发展的研究环境，将继续加强研究基础设施， 将在第三阶段结束时为中心的长期可持续性提供一条途径。

PROJECT SUMMARY: OVERALL The goal of this Phase 2 COBRE application is to continue to develop a unique, nationally recognized, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). We will build on Phase 1 successes by further enhancing research infrastructure and continuing to build a critical mass of investigators studying cognitive and neural plasticity. We will continue to develop the plasticity thematic focus of the center by supporting research in three new cross-cutting thematic areas: The Neurobiology of Learning and Memory, Neuromodulation and Assessment, and Advanced Computational Modeling. The cross-cutting themes bridge across animal models and human translational research, and across disciplines. The cross- cutting themes reflect the planned enhancements of the research cores, knit together the current projects, will guide priorities for faculty recruitment and future pilot grant and replacement project grant selection, and will inform future program development initiatives. Further development of the CNAP center and its associated programs will propel us toward achieving our goal of improving cognitive and neural functioning in both healthy populations and in individuals with specific diseases or disorders. CNAP center development will be advanced through the achievement of four specific aims: (1) To promote R01 award success for CNAP project and pilot grant leaders. In Phase 2, we will support three new research project leaders who have strong potential to transition to R01-level support. In addition, following the success of our active pilot grant program in Phase 1, we will continue to fund pilot grants annually in Years 2-5, providing further opportunities for graduation of junior investigators to R01-level research support. (2) To continue to develop a critical mass of researchers in cognitive/neural plasticity through recruitment of new CNAP members. We will recruit three new tenure-track faculty in research areas relevant to the CNAP cross-cutting themes. We will further expand CNAP membership by funding new pilot grants and expanding the research cores. (3) To further improve research infrastructure by expanding three multi-user core laboratory facilities. We will expand the Behavioral Neuroscience Core, Cognitive Neuroscience Core, and Neuroinformatics Core by adding significant new capabilities to promote access to modern neuroscience and computational modeling techniques. (4) To enhance the research capabilities of CNAP center members through strengthening the Scientific Exchange Network (SEN). The SEN will provide CNAP researchers access to additional core facilities and training to increase their capability to secure extramural funding. Achieving these aims will further advance a thriving thematic research center that will increase the understanding of cognitive and neural mechanisms of plasticity. CNAP will attract extramural funding through individual investigator and partnership grants, will promote a rich research climate for fostering investigator development, will continue to enhance research infrastructure, and will provide a pathway to long-term center sustainability by the end of Phase 3.