Center for Cancer Control in Persistent Poverty Areas (C3P2)

持续贫困地区癌症防治中心（C3P2）

• 批准号: 10660380
• 负责人: MONA N. FOUAD
• 金额: $ 193.79万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660380
• 关键词: Achievement; Address; Adoption; Affect; Alabama; Area; Attention; Behavior; Behavioral; Cancer Burden; Cancer Center; Cancer Control; Cancer Control Research; Censuses; Collaborations; Colorectal Cancer; Common Data Element; Communities; Complex; County; Development; Dissemination and Implementation; Education; Ensure; Environment; Evaluation; Evidence based practice; Geographic Locations; Goals; Health Promotion; Health behavior change; High Prevalence; Incidence; Individual; Infrastructure; Institution; Intervention; Knowledge; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mentorship; Modeling; Monitor; National Cancer Institute; Obesity; Obesity associated cancer; Outcome; Personal Satisfaction; Physical environment; Pilot Projects; Population; Positioning Attribute; Poverty; Poverty Areas; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Rural; Rural Community; Social Environment; Stress; System; Training; Universities; University of Alabama at Birmingham Cancer Center; Work; anticancer research; cancer health disparity; cancer prevention; cancer risk; career; community engagement; community living; community partnership; data tools; early experience; effectiveness testing; efficacious intervention; evidence base; experience; health care availability; health care service utilization; improved; inner city; innovation; malignant breast neoplasm; mortality; mortality risk; multidisciplinary; neighborhood disadvantage; poor communities; prevent; program dissemination; programs; social; social cohesion; social health determinants; social structure; supportive environment; survivorship; synergism; therapy design; tool

OVERALL ABSTRACT Cancer mortality is higher in areas of the US affected by Persistent Poverty (PP) compared to areas in which poverty has not persisted for decades, especially for obesity-related cancers like breast, prostate, and colorectal cancer. While reasons may be multifaceted, the role of social determinants of health (SDH) cannot be overlooked, including aspects of the Living Environments (e.g., physical and social) and their “downstream” effects on behaviors that impact health promotion and increase cancer risk and mortality. In 2021, Alabama ranked 8th in the US for poverty. The state includes some of the most impoverished inner-city and rural communities in the nation, and thus a considerable number of both urban and rural Census Tracts (CTs) identified as PP areas by the National Cancer Institute (NCI). The overall goal of the University of Alabama at Birmingham (UAB) Center for Cancer Control in Persistent Poverty Areas (C3P2) is to reduce the burden of cancer and cancer disparities in PP areas by expanding research and research capacity through implementation and evaluation of multilevel interventions to improve cancer outcomes across the cancer control continuum from prevention to survivorship. The C3P2 goal will be achieved through: 1) Establishment and support of two transdisciplinary, multi-level, multi-domain research projects to adapt, implement, and evaluate multilevel interventions across the cancer control continuum from prevention to survivorship, as well as pilot projects through a Developmental Core; 2) Establishment of a coordinated C3P2 infrastructure to support and strengthen the C3P2 research agenda by: a) providing overall integrated management and comprehensive evaluation, b) providing common research resources and measures to promote project integration and collaboration (Administrative and Research and Methods Cores); 3) Development of a pipeline of investigators for cancer control research in PP areas by providing training, support, and research experience opportunity to early career investigators (Career Enhancement Core); 4) Academic-community partnership building with establishment of a Community Advisory Board and engagement of Community COaCHes to support innovative and salient research in the community, and monitoring and evaluation to ensure achievement of proposed goals. (Administrative Core). Our multi-disciplinary team of established and early career investigators, working in a supportive environment with the resources and commitment to address and challenges in PP areas to cancer prevention and control, are well positioned to make an impact in PP communities of Alabama and improve cancer outcomes. The C3P2 will serve as a model to improve cancer prevention and control for other PP areas in Alabama and other states.

总体摘要 美国受持续贫困（PP）影响的地区的癌症死亡率高于 贫困并没有持续几十年，特别是与肥胖有关的癌症，如乳腺癌、前列腺癌和结肠直肠癌。 癌虽然原因可能是多方面的，但健康的社会决定因素的作用不能被忽视。 被忽视的，包括生活环境的各个方面（例如，物质和社会）及其“下游” 对影响健康促进和增加癌症风险和死亡率的行为的影响。2021年，亚拉巴马 在美国贫困人口中排名第八。该州包括一些最贫困的市中心和农村地区， 因此，相当数量的城市和农村人口普查区（CT） 被美国国家癌症研究所（NCI）确定为PP区域。亚拉巴马大学的总体目标是 伯明翰（UAB）癌症控制中心在持续贫困地区（C3 P2）是为了减轻负担， 通过扩大研究和研究能力， 实施和评估多层次干预措施，以改善整个癌症控制系统的癌症结局 从预防到生存。C3 P2目标将通过以下方式实现：1）建立和 支持两个跨学科，多层次，多领域的研究项目，以适应，实施和评估 从预防到生存的癌症控制连续体的多层次干预，以及试点 2）建立协调的C3 P2基础设施，以支持和 通过以下方式加强C3 P2研究议程：a）提供全面的综合管理和全面的 评估，B）提供共同的研究资源和措施，以促进项目整合， 合作（行政和研究及方法核心）; 3）开发调查人员管道 通过提供培训、支持和研究经验机会， 早期职业调查员（职业提升核心）; 4）学术社区伙伴关系建设， 建立社区咨询委员会，并让社区教练参与， 以及监测和评价，以确保实现拟议的 目标.（行政核心）。我们的多学科团队由成熟的和早期的职业调查人员组成， 在一个支持性的环境中，有资源和承诺来解决PP领域的挑战， 癌症预防和控制，是很好的定位，使在亚拉巴马的PP社区的影响， 改善癌症预后。C3 P2将作为改善其他癌症预防和控制的模型。 亚拉巴马和其他州的PP地区。