Metabolic and hemodynamic sensor for monitoring throughout the continuum of care

用于在整个护理过程中进行监测的代谢和血流动力学传感器

• 批准号: 10659906
• 负责人: Elliot Lawrence Botvinick
• 金额: $ 61.32万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659906
• 关键词: Address; Admission activity; Alkalosis; American; Area; Blood; Continuity of Patient Care; Control Groups; Data; Department of Defense; Devices; Diabetes Mellitus; Diagnosis; Early Diagnosis; Educational workshop; Environment; Feedback; Glucose; Goals; Grant; Health Sciences; Health Services Research; Heart Rate; Hemoglobin; Hemorrhage; Hospitals; Human; Hybrids; In Vitro; Injury; International; Intervention; Intramuscular; Lactic Acidosis; Legal patent; Measurement; Measures; Mechanics; Medical; Metabolic; Monitor; Morbidity - disease rate; National Institute of Biomedical Imaging and Bioengineering; Obstructive Lung Diseases; Operative Surgical Procedures; Outcome; Oxygen; Patients; Performance; Peripheral; Physiologic Monitoring; Physiological; Point of Care Technology; Process; Publishing; Pulse Oximetry; Recommendation; Reporting; Research; Respiratory Acidosis; Resuscitation; Risk; Running; Sepsis; Shock; Signal Transduction; Skin; Symptoms; System; Technology; Telemetry; Testing; Time; Tissues; Training; Transportation; Trauma; Triage; United States National Institutes of Health; University Health Services; Work; casualty care; clinical research site; combat casualty; data exchange; design and construction; flexibility; glucose sensor; glycemic control; heart rate monitor; heart rhythm; hemodynamics; human subject; improved; improved outcome; in vivo; injured; interest; minimally invasive; mortality; operation; point of injury; porcine model; programs; prolonged field care; real time monitoring; research and development; sensor; sensor technology; standard of care; subcutaneous; tool; transmission process; trauma care; trend; vasoconstriction; wireless; wireless transmission

Project Summary This project will develop a wearable continuous monitor for reporting and predicting physiological state during trauma, shock and sepsis with the goal of predicting morbidity, mortality, and providing feedback during medical intervention. I can also be used as a triage tool. The proposed technology responds to technology gaps published by the Department of Defense Combat Casualty Care Research Program and an NIH Notice of Special Interest in Physiological Monitoring and Point of Care Technologies for Trauma Care. The hybrid technology has an ultra- thin flexible multiple analyte sensor placed just under the skin attached to a flexible wearable patch for non- invasive hemodynamic monitoring. Together these technologies provide real time monitoring of blood oxygenation, heart rate, lactate, tissue oxygen, glucose, and pH. In Aim 1 we will design and construct a minimally invasive continuous sensor for glucose, lactate, oxygen and pH. It has been shown that frequent monitoring of these analytes not only identifies risk at initial injury, but can predict morbidity and outcomes, guide intervention, and stratify medical conditions associated with trauma that may have overlapping or cryptic symptoms. In Aim 2 we will design and construct a wearable patch that operates the sensor developed in Aim1 and further includes the non-invasive technology of pulse oximetry, autonomous operation, and wireless telemetry. The wearable and sensor are both made of flexible circuits providing comfort and mechanical matching of the indwelling component, and conformal attachment of the wearable to the skin. In Aim 3 we will conduct a study using a porcine model of hemorrhagic injury and sensor-guided resuscitation. At the completion of the grant, we will have a validated monitoring technology and can begin the process of applying for an Investigational Device Exemption from the FDA to proceed to human studies.

项目总结