Hippocampal-Neocortical Interactions During Naturalistic Learning

自然学习过程中海马-新皮质的相互作用

• 批准号: 10659883
• 负责人: Anli A Liu
• 金额: $ 69.19万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-10 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659883
• 关键词: Acceleration; Address; Affect; Alzheimer' s Disease; Brain; Clinical; Complex; Coupled; Data Set; Diagnosis; Electric Stimulation; Electroencephalography; Epilepsy; Episodic memory; Event; Exposure to; Film; Functional Magnetic Resonance Imaging; Future; Goals; High Frequency Oscillation; Hippocampus; Human; Investigation; Knowledge; Learning; Life; Measures; Medial; Memory; Memory Disorders; Memory impairment; Methods; Modeling; Monitor; Neocortex; Operative Surgical Procedures; Pathologic; Patients; Performance; Periodicity; Persons; Play; Population; Process; Random Allocation; Resolution; Rest; Rodent; Role; Series; Signal Transduction; Sleep; Speed; Structure; Testing; Time; Translations; Traumatic Brain Injury; Work; cognitive neuroscience; epileptiform; episodic memory impairment; experience; forgetting; innovation; memory consolidation; memory retrieval; millisecond; neocortical; nervous system disorder; neural; neuroimaging; neuromechanism; neurophysiology; neuropsychiatric disorder; novel strategies; remediation; spatiotemporal; way finding

PROJECT SUMMARY Episodic memories are representations of our personal past, anchored to time and space. Episodic memory impairments in neurological disorders like epilepsy, traumatic brain injury, and Alzheimer’s Disease significantly limit patients’ ability to work and live independently. In everyday life, the brain must process the continuous present to form discrete memories of the past. This ability to parse experience into meaningful chunks, termed event segmentation, is foundational to human episodic memory. Functional neuroimaging studies suggest that the hippocampus and a posterior cortical network demonstrate a simultaneous increase in activity at event boundaries and endings, but the neural events supporting this demarcation are unknown. Numerous rodent studies suggest that neural oscillations—particularly theta, gamma, and sharp-wave ripple (SWR) activity—coordinate hippocampal-neocortical interactions at these critical junctures. Our long-term goal is to discover how the brain organizes and consolidates continuous experience under naturalistic circumstances. The objective of this proposal is to measure the hippocampal-neocortical dynamics at key moments in episodic memory. Our central hypothesis is that the hippocampus plays a critical role in segmenting and consolidating information delivered from the neocortex, via enhanced theta-gamma activity at event boundaries and increased SWR rate during post-viewing rest. To test these main hypotheses, we will obtain intracranial EEG (iEEG) recordings from epilepsy patients undergoing invasive monitoring for surgical treatment. Subjects will view a series of short films that possess a narrative structure and sequence, then will be asked to recall selected content. Upon successful completion of this project, we will accomplish the following aims: Aim 1. To measure the relative contributions of hippocampus and PMN to event segmentation during film viewing. Aim 2. To measure the hippocampal contribution to memory consolidation during post- viewing rest. Aim 3. To test the necessity of the hippocampus for event segmentation through electrical stimulation (ES). This proposal represents a significant advance from prior work in the cognitive neuroscience of memory by using iEEG to determine the hippocampal-neocortical oscillations involved in remembering naturalistic events. This project is innovative in concept and method because of (1) the use of short films to investigate human episodic memory; (2) the translation of key neurophysiological findings in rodent memory to human episodic memory; and (3) establishing the necessity of the hippocampus in event segmentation and memory performance through ES. Our findings will advance mechanism-guided approaches to the assessment and remediation of memory dysfunction in neuropsychiatric disorders such as epilepsy and traumatic brain injury.

项目概要 情景记忆是我们个人过去的表现，锚定于时间和空间。情景式 癫痫、脑外伤和阿尔茨海默病等神经系统疾病导致的记忆障碍 严重限制了患者独立工作和生活的能力。在日常生活中，大脑必须处理 连续的现在形成对过去的离散记忆。这种将经验解析为有意义的能力 块，称为事件分割，是人类情景记忆的基础。功能神经影像学 研究表明，海马体和后皮质网络表现出同时增加 事件边界和结局处的活动，但支持这种划分的神经事件尚不清楚。 大量啮齿类动物研究表明，神经振荡——尤其是 θ、γ 和尖波波纹 (SWR) 活动——协调这些关键时刻的海马-新皮质相互作用。 我们的长期目标是发现大脑如何组织和巩固连续的经验 自然主义的情况。该提案的目的是测量海马-新皮质动力学 在情景记忆的关键时刻。我们的中心假设是海马体在 通过增强的 theta-gamma 活动，分割和整合从新皮质传递的信息 事件边界和观看后休息期间增加的 SWR 率。为了检验这些主要假设，我们将 获取接受侵入性手术监测的癫痫患者的颅内脑电图 (iEEG) 记录 治疗。受试者将观看一系列具有叙事结构和顺序的短片，然后 被要求回忆选定的内容。成功完成该项目后，我们将完成 以下目标： 目标 1. 测量海马和 PMN 对事件分割的相对贡献 观影过程中。目标 2. 测量海马对后记忆巩固的贡献 观看休息。目标 3. 测试海马体通过电进行事件分割的必要性 刺激（ES）。 该提案代表了记忆认知神经科学先前工作的重大进步 使用 iEEG 来确定参与记忆自然事件的海马新皮质振荡。 该项目在理念和方法上都有创新之处，因为（1）利用短片来研究人类 情景记忆； (2) 将啮齿动物记忆中的关键神经生理学发现转化为人类情景记忆 记忆; (3)建立海马体在事件分割和记忆中的必要性 通过ES表现。我们的研究结果将推动以机制为导向的评估方法和 修复神经精神疾病（如癫痫和创伤性脑损伤）中的记忆功能障碍。