How Visuospatial Memory Shapes Perception of Real-World Environments

视觉空间记忆如何塑造对现实世界环境的感知

• 批准号: 10659330
• 负责人: Caroline Elizabeth Robertson
• 金额: $ 41万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-07 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659330
• 关键词: Affect; Aging; Alzheimer' s Disease; Anterior; Area; Behavior; Biological Models; Brain; Brain region; Code; Data; Dementia; Educational process of instructing; Environment; Functional Magnetic Resonance Imaging; Grain; Head; Health; Hippocampus; Human; Individual; Knowledge; Learning; Life; Macular degeneration; Memory; Nature; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Participant; Pattern; Perception; Population; Published Comment; Rehabilitation therapy; Research; Saccades; Semantics; Shapes; Signal Transduction; Steel; Structure; Support System; Symptoms; System; Testing; Vision; Visual; Visual Cortex; Visual Perception; Visual impairment; Visuospatial; Williams Syndrome; Work; cortical visual impairment; developmental disease; expectation; experience; healthy aging; insight; knowledge of results; member; multimodality; neural; novel; novel strategies; predictive modeling; response; retinotopic; spatial memory; virtual reality; virtual reality headset; visual processing; visual tracking; way finding

Project Abstract One long-standing puzzle in neuroscience is how scene perception and spatial memory systems – which are topographically distinct in the brain – interface to enable memory-guided visual behavior. In the context of scene perception, two crucial knowledge gaps remain. First, how does visuospatial memory of the local environment facilitate ongoing scene perception? Second, what are the neural underpinnings of memory-guided scene perception? The current project will tackle these questions by combining head-mounted virtual reality (VR), eye-tracking, and fine-grained within-subject fMRI. We will teach participants immersive, real-world environments and test how memory-guided scene processing is implemented in the brain and behavior. In doing so, we will advance a new mechanistic hypothesis as to the neural basis of memory-based predictive coding for scene processing. Together, this project will produce fundamental knowledge about how stored knowledge about the world influences ongoing perception during naturalistic visual experience, and how the brain accomplishes memory-guided visual behaviors like navigation. The resulting knowledge promises impact for our numerous health conditions such as Alzheimer’s, dementia, macular degeneration, cortical visual impairments, and healthy aging, in which both the visual behaviors and brain regions investigated here are implicated.

项目摘要 神经科学中一个长期存在的难题是场景感知和空间记忆如何 系统 - 大脑中的地形不同 - 接口以实现记忆引导 视觉行为。在场景感知的背景下，仍然存在两个关键的知识差距。一、如何 对当地环境的视觉空间记忆是否有助于持续的场景感知？第二， 记忆引导的场景感知的神经基础是什么？ 当前的项目将通过结合头戴式虚拟现实来解决这些问题 (VR)、眼球追踪和细粒度受试者内功能磁共振成像。我们将教导参与者身临其境， 真实世界环境并测试如何在现实环境中实现内存引导的场景处理 大脑和行为。在此过程中，我们将提出一个关于神经元的新机制假设 用于场景处理的基于内存的预测编码的基础。 该项目将共同产生有关如何存储知识的基础知识 关于世界的影响在自然视觉体验中持续的感知，以及如何 大脑完成记忆引导的视觉行为，例如导航。由此产生的知识 有望对我们的多种健康状况产生影响，例如阿尔茨海默病、痴呆症、黄斑病 退化、皮质视觉障碍和健康衰老，其中视觉行为 这里研究的大脑区域也受到牵连。