How Visuospatial Memory Shapes Perception of Real-World Environments

视觉空间记忆如何塑造对现实世界环境的感知

• 批准号: 10659330
• 负责人: Caroline Elizabeth Robertson
• 金额: $ 41万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-07 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659330
• 关键词: Affect; Aging; Alzheimer' s Disease; Anterior; Area; Behavior; Biological Models; Brain; Brain region; Code; Data; Dementia; Educational process of instructing; Environment; Functional Magnetic Resonance Imaging; Grain; Head; Health; Hippocampus; Human; Individual; Knowledge; Learning; Life; Macular degeneration; Memory; Nature; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Participant; Pattern; Perception; Population; Published Comment; Rehabilitation therapy; Research; Saccades; Semantics; Shapes; Signal Transduction; Steel; Structure; Support System; Symptoms; System; Testing; Vision; Visual; Visual Cortex; Visual Perception; Visual impairment; Visuospatial; Williams Syndrome; Work; cortical visual impairment; developmental disease; expectation; experience; healthy aging; insight; knowledge of results; member; multimodality; neural; novel; novel strategies; predictive modeling; response; retinotopic; spatial memory; virtual reality; virtual reality headset; visual processing; visual tracking; way finding

Project Abstract One long-standing puzzle in neuroscience is how scene perception and spatial memory systems – which are topographically distinct in the brain – interface to enable memory-guided visual behavior. In the context of scene perception, two crucial knowledge gaps remain. First, how does visuospatial memory of the local environment facilitate ongoing scene perception? Second, what are the neural underpinnings of memory-guided scene perception? The current project will tackle these questions by combining head-mounted virtual reality (VR), eye-tracking, and fine-grained within-subject fMRI. We will teach participants immersive, real-world environments and test how memory-guided scene processing is implemented in the brain and behavior. In doing so, we will advance a new mechanistic hypothesis as to the neural basis of memory-based predictive coding for scene processing. Together, this project will produce fundamental knowledge about how stored knowledge about the world influences ongoing perception during naturalistic visual experience, and how the brain accomplishes memory-guided visual behaviors like navigation. The resulting knowledge promises impact for our numerous health conditions such as Alzheimer’s, dementia, macular degeneration, cortical visual impairments, and healthy aging, in which both the visual behaviors and brain regions investigated here are implicated.

项目摘要 神经科学中一个长期存在的难题是， 系统-这是地形不同的大脑-接口，使记忆引导 视觉行为在场景感知的背景下，两个关键的知识差距仍然存在。一是如何 局部环境的视觉空间记忆是否促进了持续的场景感知？第二、 记忆引导的场景感知的神经基础是什么？ 目前的项目将通过结合头戴式虚拟现实来解决这些问题 (VR)眼动追踪和精细的受试者内功能磁共振成像。我们将教参与者身临其境， 真实世界的环境中，并测试如何内存引导的场景处理是在 大脑和行为在这样做的过程中，我们将提出一个新的机制假设， 基于存储器的预测编码的场景处理的基础。 总之，这个项目将产生关于如何存储知识的基本知识， 在自然主义视觉体验中，关于世界的影响正在进行的感知，以及 大脑完成记忆引导的视觉行为，如导航。由此产生的知识 承诺对我们的许多健康状况，如阿尔茨海默氏症，痴呆症，黄斑 退化，皮质视觉障碍，以及健康的老龄化，其中视觉行为 这里研究的大脑区域也受到影响。