How Visuospatial Memory Shapes Perception of Real-World Environments

视觉空间记忆如何塑造对现实世界环境的感知

基本信息

批准号：
10659330
负责人：
Caroline Elizabeth Robertson
金额：
$ 41万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-07 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659330
关键词：
Affect Aging Alzheimer&apos s Disease Anterior Area Behavior Biological Models Brain Brain region Code Data Dementia Educational process of instructing Environment Functional Magnetic Resonance Imaging Grain Head Health Hippocampus Human Individual Knowledge Learning Life Macular degeneration Memory Nature Nerve Degeneration Neurodegenerative Disorders Neurosciences Participant Pattern Perception Population Published Comment Rehabilitation therapy Research Saccades Semantics Shapes Signal Transduction Steel Structure Support System Symptoms System Testing Vision Visual Visual Cortex Visual Perception Visual impairment Visuospatial Williams Syndrome Work cortical visual impairment developmental disease expectation experience healthy aging insight knowledge of results member multimodality neural novel novel strategies predictive modeling response retinotopic spatial memory virtual reality virtual reality headset visual processing visual tracking way finding

项目摘要

Project Abstract One long-standing puzzle in neuroscience is how scene perception and spatial memory systems – which are topographically distinct in the brain – interface to enable memory-guided visual behavior. In the context of scene perception, two crucial knowledge gaps remain. First, how does visuospatial memory of the local environment facilitate ongoing scene perception? Second, what are the neural underpinnings of memory-guided scene perception? The current project will tackle these questions by combining head-mounted virtual reality (VR), eye-tracking, and fine-grained within-subject fMRI. We will teach participants immersive, real-world environments and test how memory-guided scene processing is implemented in the brain and behavior. In doing so, we will advance a new mechanistic hypothesis as to the neural basis of memory-based predictive coding for scene processing. Together, this project will produce fundamental knowledge about how stored knowledge about the world influences ongoing perception during naturalistic visual experience, and how the brain accomplishes memory-guided visual behaviors like navigation. The resulting knowledge promises impact for our numerous health conditions such as Alzheimer’s, dementia, macular degeneration, cortical visual impairments, and healthy aging, in which both the visual behaviors and brain regions investigated here are implicated.

项目摘要神经科学中的一个长期难题是场景感知和空间记忆的方式系统 - 在大脑中在地形上不同的系统 - 接口以启用记忆引导视觉行为。在场景感知的背景下，仍然存在两个关键的知识差距。首先，怎么样当地环境的视觉记忆是否有助于持续的场景感知？第二，记忆引导场景感知的神经基础是什么？当前的项目将通过结合头部安装的虚拟现实来解决这些问题（VR），眼睛跟踪和受试者内FMRI。我们将教参与者身临其境，现实世界的环境并测试如何在内存引导的场景处理中实现大脑和行为。这样，我们将提出关于神经的新机械假设基于内存的预测编码为场景处理的基础。该项目一起将产生有关存储知识如何的基本知识关于世界在自然主义的视觉体验期间的持续看法，以及如何大脑完成了记忆引导的视觉行为，例如导航。由此产生的知识承诺对我们众多健康状况的影响，例如阿尔茨海默氏症，痴呆症，黄斑变性，皮质视觉障碍和健康衰老，其中两种视觉行为和这里研究的大脑区域牵涉。