Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological Correlates

帕金森病临床亚型：验证、临床实用性和生物学相关性

基本信息

批准号：
10659637
负责人：
MEGHAN C CAMPBELL
金额：
$ 60.33万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659637
关键词：
Abbreviations Amyloid beta-Protein Atrophic Autonomic Dysfunction Autopsy Behavior assessment Behavioral Biological Biological Markers Brain Brain Pathology Classification Clinical Clinical Data Clinical assessments Cognition Cognitive Corpus striatum structure Data Data Set Dementia Deposition Development Disease Progression Economic Burden Evaluation Family Freezing Functional Magnetic Resonance Imaging Functional disorder Gait Hallucinations Impaired cognition Impairment Individual Intervention Longitudinal cohort Magnetic Resonance Imaging Measures Medical Records Methods Midbrain structure Morbidity - disease rate Motor Movement Disorders Neurobiology Neurodegenerative Disorders Neurotransmitters Orthostasis Outcome Outcome Study Parkinson Disease Participant Pathology Patient Selection Patients Pattern Positron-Emission Tomography Proteins Research Severity of illness Societies Statistical Models Subgroup System Testing Time Tracer Translating Validation alpha synuclein cholinergic clinical application clinical movement disorder clinical subtypes clinically relevant cognitive function cohort dementia risk disorder subtype falls improved mortality motor deficit motor impairment multimodal neuroimaging multimodality non-motor symptom noradrenaline transporter noradrenergic novel patient health information patient stratification personalized intervention personalized medicine prevent prognostic value psychiatric symptom screening tau Proteins tool

项目摘要

ABSTRACT Parkinson disease (PD) is a progressive neurodegenerative disease characterized by motor, cognitive, and psychiatric manifestations resulting from abnormal protein deposition and neurotransmitter deficits. The variability in clinical presentation and progression likely reflects different PD subtypes, which may be associated with the underlying variability in brain pathology. Although current treatments provide dramatic motor benefit in PD, they fail to alleviate some aspects of gait impairment and non-motor symptoms and may exacerbate cognitive and psychiatric features. To develop more personalized interventions to treat, forestall or prevent these features, more information regarding PD subtypes is necessary for patient selection and stratification, predicting progression, and evaluation of novel treatments. Therefore, we propose to examine the clinical and prognostic utility of PD subtypes and their stability through longitudinal behavioral assessments; determine the biological markers of PD subtypes from multimodal neuroimaging, CSF, and brain autopsy data; and translate the PD subtypes to a clinical setting.

抽象的帕金森氏病（PD）是一种进行性神经退行性疾病，其特征是运动，认知和异常蛋白质沉积和神经递质缺陷引起的精神病表现。这临床表现和进展的变异性可能反映了不同的PD亚型，这可能与具有脑病理学的潜在差异。尽管目前的治疗可在 PD，它们无法缓解步态障碍和非运动症状的某些方面，并可能加剧认知和精神病特征。制定更个性化的干预措施来治疗，防止或防止这些干预措施功能，有关PD亚型的更多信息对于患者选择和分层是必需的，预测进展和评估新治疗。因此，我们建议检查临床和预后 PD亚型的效用及其稳定性通过纵向行为评估；确定生物学来自多模式神经成像，CSF和脑尸检数据的PD亚型标记；并翻译PD 亚型至临床环境。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Detecting associations between intact connectomes and clinical covariates using recursive partitioning object-oriented data analysis.

使用递归分区面向对象的数据分析来检测完整连接组和临床协变量之间的关联。

DOI：
10.1002/sim.8374
发表时间：
2019
期刊：
Statistics in medicine
影响因子：
2
作者：
Yang,Dake;Deych,Elena;Shands,Berkley;Campbell,MeghanC;Perlmutter,JoelS;Petersen,Steve;Schlaggar,BradleyL;Shannon,William
通讯作者：
Shannon,William

Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?

DOI：
10.1016/j.toxicon.2017.09.004
发表时间：
2018-06-01
期刊：
TOXICON
影响因子：
2.8
作者：
Jinnah, H. A.;Comella, Cynthia L.;Hallett, Mark
通讯作者：
Hallett, Mark

Head tremor in cervical dystonia: Quantifying severity with computer vision.

DOI：
10.1016/j.jns.2022.120154
发表时间：
2022-03-15
期刊：
JOURNAL OF THE NEUROLOGICAL SCIENCES
影响因子：
4.4
作者：
Vu, Jeanne P.;Cisneros, Elizabeth;Lee, Ha Yeon;Le, Linh;Chen, Qiyu;Guo, Xiaoyan A.;Rouzbehani, Ryin;Jankovic, Joseph;Factor, Stewart;Goetz, Christopher G.;Barbano, Richard L.;Perlmutter, Joel S.;Jinnah, Hyder A.;Richardson, Sarah Pirio;Stebbins, Glenn T.;Elble, Rodger;Comella, Cynthia L.;Peterson, David A.
通讯作者：
Peterson, David A.

ESM-CT: a precise method for localization of DBS electrodes in CT images.

DOI：
10.1016/j.jneumeth.2018.09.009
发表时间：
2018-10-01
期刊：
Journal of neuroscience methods
影响因子：
3
作者：
Milchenko M;Snyder AZ;Campbell MC;Dowling JL;Rich KM;Brier LM;Perlmutter JS;Norris SA
通讯作者：
Norris SA

Quantitative, clinically relevant acoustic measurements of focal embouchure dystonia.

局灶性口型肌张力障碍的定量、临床相关声学测量。