Investigating the Phenomenology and Physiologic Underpinnings of Decreased Sound Tolerance in Adults with Autism Spectrum Disorder

调查患有自闭症谱系障碍的成人声音耐受性下降的现象学和生理学基础

基本信息

  • 批准号:
    10658844
  • 负责人:
  • 金额:
    $ 5.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary Individuals with autism spectrum disorder (ASD) exhibit multiple differences in sensory perception, which have now been recognized as a core feature of the condition. Among these sensory differences, decreased sound tolerance (DST; i.e., an inability to cope with everyday sounds) is particularly salient, with a lifetime prevalence of 50–70% in the ASD population. Despite both first-person accounts and empirical studies indicating that DST is a major source of distress and functional impairment in ASD, little is known about the phenomenology or physiologic underpinnings of this symptom cluster, and no evidence-based treatments for DST in ASD are currently available. Some researchers have suggested that the adverse reactions seen in ASD are manifestations of hyperacusis, reflecting disordered loudness perception. However, others contend that exaggerated emotional responses to specific acoustic stimuli underlie these behaviors, indicating that DST in ASD could be a form of misophonia, a psychiatric disorder characterized by excessive emotional reactions to specific “trigger” sounds. To date, little empirical work has tested these hypotheses against one another, and it remains an open question whether DST in ASD reflects hyperacusis, misophonia, or a combination of the two. Furthermore, it remains unknown whether these symptoms are associated with alterations in the peripheral or central auditory system. The proposed study aims to answer these questions using a two-stage approach. In stage 1, we will construct a novel self-report questionnaire that assesses a wide range of DST symptoms spanning the four theoretical domains of loudness, pain, annoyance (i.e., misophonia), and fear. Available measures of DST typically assess only the loudness (hyperacusis) or annoyance (misophonia) dimensions, failing to address a number of other clinically significant symptoms. Utilizing large online samples of adults with and without ASD, we will refine and psychometrically validate our questionnaire for use as a quantitative measure of transdiagnostic DST symptoms. In stage 2, we will recruit adults with ASD (both with and without DST) and healthy controls from the community, characterizing their auditory function using a battery of psychoacoustic and physiological tests. Auditory perception will be assessed using pure tone audiometry, loudness discomfort level testing, and categorical loudness scaling. Underlying auditory physiology will be assessed from the middle ear to auditory cortex using a combination of tympanometry, acoustic reflex testing, otoacoustic emission suppression, brainstem/cortical auditory event-related potentials, and auditory steady-state responses. Objective auditory measures will be compared between diagnostic groups, and relationships between these measures and subjective DST symptomatology (based on established surveys and the novel self-report developed in stage 1) will be explored across the full stage 2 sample. This project will answer the fundamental question of whether DST in ASD represents a variant of hyperacusis, misophonia, or a combination of the two. Furthermore, by relating DST symptoms to underlying physiology, we will determine whether different dimensions of DST can be separated based on their physiologic correlates. Findings from this study are expected to elucidate the psychological and physiological mechanisms of DST in ASD, improving our understanding of this disabling symptom and guiding the development of targeted interventions for the ASD population.
项目总结

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Race and Sex Bias in the Autism Diagnostic Observation Schedule (ADOS-2) and Disparities in Autism Diagnoses.
  • DOI:
    10.1001/jamanetworkopen.2022.9503
  • 发表时间:
    2022-04-01
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Williams, Zachary J.
  • 通讯作者:
    Williams, Zachary J.
Improving the measurement of alexithymia in autistic adults: a psychometric investigation and refinement of the twenty-item Toronto Alexithymia Scale.
  • DOI:
    10.1186/s13229-021-00427-9
  • 发表时间:
    2021-03-02
  • 期刊:
  • 影响因子:
    6.2
  • 作者:
    Williams ZJ;Gotham KO
  • 通讯作者:
    Gotham KO
Sex and gender in neurodevelopmental conditions.
  • DOI:
    10.1038/s41582-023-00774-6
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
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Zachary James Williams其他文献

Zachary James Williams的其他文献

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{{ truncateString('Zachary James Williams', 18)}}的其他基金

Investigating the Phenomenology and Physiologic Underpinnings of Decreased Sound Tolerance in Adults with Autism Spectrum Disorder
调查患有自闭症谱系障碍的成人声音耐受性下降的现象学和生理学基础
  • 批准号:
    10363654
  • 财政年份:
    2021
  • 资助金额:
    $ 5.06万
  • 项目类别:
Investigating the Phenomenology and Physiologic Underpinnings of Decreased Sound Tolerance in Adults with Autism Spectrum Disorder
调查患有自闭症谱系障碍的成人声音耐受性下降的现象学和生理学基础
  • 批准号:
    10229243
  • 财政年份:
    2021
  • 资助金额:
    $ 5.06万
  • 项目类别:

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