Microbiome Multi-Omics and Cognitive Decline in Latinos

微生物组多组学和拉丁裔认知能力下降

• 批准号: 10661289
• 负责人: Natalia Palacios
• 金额: $ 202.07万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661289
• 关键词: Acculturation; Address; Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amino Acids; Amyloid; Area; Behavioral; Bifidobacterium; Bile Acids; Bioinformatics; Biological; Boston; Brain; Branched-Chain Amino Acids; Cholesterol Homeostasis; Cholic Acids; Chronic Disease; Cognition; Cognitive; Communication; Data; Dementia; Deoxycholic Acid; Diagnosis; Diet; Disparity; Ecosystem; Education; Epidemic; Epidemiology; Escherichia; Feces; Functional disorder; Funding; Future; Health; Human; Impaired cognition; Inflammation; Intervention; Investigation; Isoleucine; Latino Population; Leucine; Life Style; Light; Longitudinal Studies; Longitudinal cohort; Magnetic Resonance Imaging; Maps; Measures; Metabolic; Metabolic syndrome; Metagenomics; Microbial Taxonomy; Minority Groups; Nature; Neurocognitive; Neuroepidemiology; Neurotransmitters; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Pattern; Peptides; Plasma; Population; Prevention; Prevotella; Production; Prospective Studies; Proteins; Public Health; Puerto Rican; Research; Resolution; Risk; Role; Stress; Structure; Study of Latinos; United States National Institutes of Health; Update; Validation; Valine; Volatile Fatty Acids; Vulnerable Populations; brain health; cognitive function; cognitive testing; cohort; community based research; cytokine; dementia risk; dietary; fatty acid metabolism; gamma-Aminobutyric Acid; gut microbiome; gut microbiota; health disparity; high risk; metabolomics; microbial; microbial community; microbiome; microbiome composition; multiple omics; neurofilament; neuroinflammation; nonalzheimer dementia; pre-clinical; precision medicine; predictive modeling; prevent; prospective; response; social; social disparities; stool sample; tool development; translational impact

Project Summary/Abstract The epidemic of Alzheimer’s disease and associated cognitive decline is a critical public health challenge that will grow as the US and world populations age. US Latinos, and particularly Puerto Ricans, suffer a disproportionate burden: Puerto Ricans are at approximately double the risk of Alzheimer’s disease compared to non-Hispanic whites. Increasing evidence points to the bi-directional communication between the brain and the gut microbiome--the gut-microbiome-brain-axis--as an important factor in brain health. Despite the promising nature of this field, limited research has been done on the association between the microbiome and cognition, particularly in minority populations. Mapping the relationship between the gut microbiome and cognition in vulnerable populations such as US-based Puerto Ricans, with excess Alzheimer disease, is key to addressing current and preventing future health disparities. The proposed project will be the largest study in a minority population to date, and the first in Puerto Ricans, on the role of the gut microbiome in cognitive decline. The proposed study will leverage an established cohort--the Boston Puerto Rican Health Study (BPRHS), a longitudinal cohort with 1499 participants at baseline, three completed waves of cognitive assessments, recent MRI, and extensive covariate data. This project will develop a framework of how the human gut microbiome multi-omics contributes to cognitive trajectory and markers of AD/ADRD in Latinos. It will leverage previously collected stool samples, MRI, and 14 years of longitudinally collected data on cognition and covariates among participants of the BPRHS. Key strengths of this proposal include: 1) leverage of a large, NIH-funded prospective study of Boston area Puerto Ricans (P01AG023394, P50HL105185, R01AG055948), an underserved and understudied minority population 2) validated and updated prospective data on cognitive decline, MRI, dietary and lifestyle covariates 3) the interdisciplinary expertise of the research team, including chronic disease epidemiology, community-based research, cognition, the microbiome, MRI and predictive modeling. This study will have a strong translational impact, enabling future microbiome-targeted interventions to promote cognitive health and will contribute to the development of tools needed for a preclinical diagnosis and/or treatment of cognitive decline and Alzheimer’s disease among this vulnerable population.

项目总结/摘要 阿尔茨海默病的流行和相关的认知能力下降是一个关键的公共卫生挑战， 随着美国和世界人口的老龄化，美国拉丁美洲人，特别是波多黎各人， 不成比例的负担：波多黎各人患阿尔茨海默病的风险大约是 非西班牙裔白人。越来越多的证据表明，大脑和大脑之间的双向交流， 肠道微生物组--肠道微生物组--大脑轴--是大脑健康的重要因素。尽管 尽管这一领域具有很大的前景，但对微生物组与 特别是在少数民族中。绘制肠道微生物组与 易受伤害人群的认知，如美国的波多黎各人，患有过多的阿尔茨海默病，是关键， 解决目前的健康差距并防止今后的差距。拟议的项目将是一个最大的研究 迄今为止，少数民族人口，以及波多黎各人中的第一个，关于肠道微生物组在认知中的作用， 下降拟议的研究将利用一个既定的队列-波士顿波多黎各健康研究 （BPRHS），一个纵向队列，1499名基线参与者，三个完整的认知波 评估、近期MRI和广泛的协变量数据。 该项目将开发一个人类肠道微生物组多组学如何有助于认知的框架 AD/ADRD在拉丁美洲人中的轨迹和标记。它将利用以前收集的粪便样本，MRI和14 年的纵向收集的数据的认知和协变量之间的参与者的BPRHS。关键 该提案的优势包括：1）利用NIH资助的波士顿地区Puerto的大型前瞻性研究 波多黎各人（P01 AG 023394、P50 HL 105185、R 01 AG 055948），服务不足且研究不足的少数民族人口 2)验证并更新了关于认知能力下降、MRI、饮食和生活方式协变量的前瞻性数据3） 研究团队的跨学科专业知识，包括慢性病流行病学，以社区为基础的 研究、认知、微生物组、MRI和预测建模。这项研究将具有很强的翻译性 影响，使未来的微生物组为目标的干预措施，以促进认知健康，并将有助于 开发认知衰退和阿尔茨海默病的临床前诊断和/或治疗所需的工具 这一脆弱群体的疾病。