Microbiome Multi-Omics and Cognitive Decline in Latinos

项目摘要/摘要 阿尔茨海默病的流行和相关的认知能力下降是一个严重的公共卫生挑战， 将随着美国和世界人口老龄化而增长。美国拉丁裔，特别是波多黎各人，遭受着 不成比例的负担：波多黎各人患阿尔茨海默病的风险大约是前者的两倍 给非西班牙裔白人。越来越多的证据表明，大脑和大脑之间的双向交流 肠道微生物群--肠道微生物群--脑轴--是大脑健康的一个重要因素。尽管 尽管这一领域前景看好，但关于微生物群和微生物之间的联系的研究有限 认知，特别是在少数群体中。绘制肠道微生物群和肠道微生物群之间的关系 像美国波多黎各人这样患有过度阿尔茨海默病的弱势人群的认知能力是 解决当前和未来的健康差距问题。拟议中的项目将是一项 到目前为止，少数族裔人口，也是波多黎各人中第一个关于肠道微生物群在认知中的作用的 拒绝。拟议的研究将利用已建立的队列--波士顿波多黎各健康研究 (BPRHS)，一个纵向队列，有1499名参与者在基线，三个完整的认知波 评估，最近的核磁共振，和广泛的协变量数据。 这个项目将开发一个人体肠道微生物组多组学如何对认知做出贡献的框架。 拉丁语AD/ADRD的轨迹和标记。它将利用之前收集的粪便样本、MRI和14 多年来，BPRHS参与者纵向收集了关于认知和协变量的数据。钥匙 这项建议的优点包括：1)利用美国国立卫生研究院资助的波士顿地区波多黎各的一项大型前瞻性研究 Ricans(P01AG023394，P50HL105185，R01AG055948)，一个服务不足和研究不足的少数民族人口 2)验证和更新了关于认知衰退、MRI、饮食和生活方式协变量的预期数据3) 研究小组的跨学科专业知识，包括社区慢性病流行病学 研究、认知、微生物组、核磁共振和预测建模。这项研究将具有很强的翻译性 影响，使未来针对微生物组的干预措施能够促进认知健康，并将有助于 开发用于认知功能减退和阿尔茨海默病的临床前诊断和/或治疗所需的工具 在这一脆弱的人群中传播疾病。

Project Summary/Abstract The epidemic of Alzheimer’s disease and associated cognitive decline is a critical public health challenge that will grow as the US and world populations age. US Latinos, and particularly Puerto Ricans, suffer a disproportionate burden: Puerto Ricans are at approximately double the risk of Alzheimer’s disease compared to non-Hispanic whites. Increasing evidence points to the bi-directional communication between the brain and the gut microbiome--the gut-microbiome-brain-axis--as an important factor in brain health. Despite the promising nature of this field, limited research has been done on the association between the microbiome and cognition, particularly in minority populations. Mapping the relationship between the gut microbiome and cognition in vulnerable populations such as US-based Puerto Ricans, with excess Alzheimer disease, is key to addressing current and preventing future health disparities. The proposed project will be the largest study in a minority population to date, and the first in Puerto Ricans, on the role of the gut microbiome in cognitive decline. The proposed study will leverage an established cohort--the Boston Puerto Rican Health Study (BPRHS), a longitudinal cohort with 1499 participants at baseline, three completed waves of cognitive assessments, recent MRI, and extensive covariate data. This project will develop a framework of how the human gut microbiome multi-omics contributes to cognitive trajectory and markers of AD/ADRD in Latinos. It will leverage previously collected stool samples, MRI, and 14 years of longitudinally collected data on cognition and covariates among participants of the BPRHS. Key strengths of this proposal include: 1) leverage of a large, NIH-funded prospective study of Boston area Puerto Ricans (P01AG023394, P50HL105185, R01AG055948), an underserved and understudied minority population 2) validated and updated prospective data on cognitive decline, MRI, dietary and lifestyle covariates 3) the interdisciplinary expertise of the research team, including chronic disease epidemiology, community-based research, cognition, the microbiome, MRI and predictive modeling. This study will have a strong translational impact, enabling future microbiome-targeted interventions to promote cognitive health and will contribute to the development of tools needed for a preclinical diagnosis and/or treatment of cognitive decline and Alzheimer’s disease among this vulnerable population.