Universal optical coherence polarimetry

通用光学相干偏振测定法

• 批准号: 10661749
• 负责人: Martin Villiger
• 金额: $ 47.77万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661749
• 关键词: Acute; Acute Coronary Event; Adoption; Algorithms; Angiography; Anisotropy; Arterial Fatty Streak; Atherosclerosis; Axon; Biological Markers; Birefringence; Blindness; Cadaver; Cardiac Catheterization Procedures; Catheters; Cause of Death; Clinic; Clinical; Clinical Research; Collaborations; Communities; Compensation; Coronary; Coronary Arteriosclerosis; Coronary artery; Custom; Data; Detection; Development; Diagnosis; Early Diagnosis; Eye; Fiber; Fiber Optics; Future; Glaucoma; Goals; Heart; Image; Imaging Device; Infrastructure; Intervention; Investigation; Light; Lighting; Lung; Magnetic Resonance Imaging; Mammary Neoplasms; Measurement; Measures; Medical; Methods; Modification; Monitor; Myocardial Infarction; Neurodegenerative Disorders; Noise; Ophthalmology; Optical Coherence Tomography; Optics; Patients; Pattern; Pilot Projects; Property; Recovery; Research; Resolution; Retina; Retinal Ganglion Cells; Rotation; Rupture; Scanning; Sclera; Signal Transduction; Structure; Syndrome; System; Thinness; Tissues; United States; Validation; Variant; Vision; Work; axonal degeneration; base; clinical application; clinical imaging; clinical translation; coronary event; cost; denoising; economic cost; empowerment; healing; image reconstruction; imaging capabilities; imaging modality; imaging platform; improved; insight; instrument; lung imaging; novel; open source; optical fiber; percutaneous coronary intervention; polarimetry; preservation; prevent; prototype; reconstruction; response; retinal imaging; retinal nerve fiber layer; signal processing

Project Summary The goal of this research is to enable the integration of advanced polarimetric imaging into existing optical coherence tomography (OCT) hardware and expedite its clinical translation. OCT is essential in contemporary ophthalmology and is routinely used to guide percutaneous coronary interventions. Extending OCT to measure polarization effects arising from tissue anisotropy affords contrast between tissues that are indiscernible in OCT’s conventional scattering signal. Polarization provides insight into the make-up and physical orientation of tissue microstructure beyond the spatial resolution of OCT. Intravascular polarimetry with polarization-sensitive (PS)-OCT offers refined insight into coronary atherosclerosis in patients suffering from myocardial infarction and other coronary syndromes and may improve patient management and guidance of percutaneous interventions. In the eye, PS-OCT has shown promise to detect alterations of the retinal nerve fiber layer (RNFL) that precede the degeneration of its retinal ganglion cell axons encountered in glaucoma, the leading cause of irreversible blindness. However, the dissemination of PS-OCT relies on adoption by a wider community, which has been hindered by the excessive hardware complexity of conventional PS-OCT. This project develops a universal and robust signal processing framework for optical coherence polarimetry (OCP) that accommodates novel simplified hardware implementations. Coherent measurements of the polarization response to propagation through tissue conventionally require polarization-diverse detection and illumination with two input states. To avoid the acute complexity of multiplexing two input states, prototype PS- OCT systems currently employed for imaging the coronary arteries or the lung use sequential input modulation. Still, this remains incompatible with the substantial commercial OCT instrument infrastructure available in the clinic today. OCP capitalizes on an intrinsic symmetry constraint manifesting in round-trip measurements performed with OCT, which enables the recovery of polarization effects from previously ill-conditioned configurations and enables adaptation of existing commercial OCT instruments to perform advanced tissue polarimetry. Aim 1 integrates concepts from magnetic resonance image reconstruction into OCP to compensate for detrimental system effects and suppress speckle-induced polarization noise. Aim 2 adapts OCP to commercial clinical intravascular OCT instruments using a single, spectrally varying input state and polarization diverse detection for investigating plaque rupture and healing in patients. Aim 3 performs OCP with retinal OCT instruments using a single spectrometer, relying on a rotating waveplate module, fitted into the accessible round-trip path and repeated scan patterns established for OCT angiography. RNFL birefringence will be investigated with the adapted clinical instruments in glaucoma patients and healthy controls. Combined, this work will provide the clinical OCT imaging community with a toolbox of algorithms that transforms existing OCT instruments with minimal modification into powerful polarimetric imaging platforms.

项目摘要 这项研究的目标是使先进的偏振成像集成到现有的光学 相干断层扫描（OCT）硬件，并加快其临床翻译。OCT在当代 眼科学并且常规用于指导经皮冠状动脉介入治疗。扩展OCT以测量 组织各向异性引起的极化效应提供了组织之间难以辨别的对比度 OCT的常规散射信号。极化提供了深入了解的组成和物理方向， 组织微结构超出OCT的空间分辨率。具有偏振敏感的血管内偏振测量 （PS）-OCT提供了对心肌梗死患者冠状动脉粥样硬化的精细见解 和其他冠状动脉综合征，并可能改善患者的管理和指导经皮冠状动脉介入治疗。 干预措施。在眼睛中，PS-OCT已经显示出检测视网膜神经纤维层改变的前景 在青光眼中遇到的视网膜神经节细胞轴突变性之前， 不可逆性失明的原因然而，PS-OCT的传播依赖于更广泛的 社区，这已经被传统的PS-OCT的过度硬件复杂性所阻碍。 本计画发展一个适用于光学相干偏振测量的通用且强健的讯号处理架构 (OCP)其适应新颖的简化硬件实现。相干测量 对通过组织传播的偏振响应通常需要偏振分集检测 具有两个输入状态的照明。为了避免复用两个输入状态的严重复杂性，原型PS- 当前用于对冠状动脉或肺成像的OCT系统使用顺序输入调制。 尽管如此，这仍然与现有技术中可用的大量商业OCT仪器基础设施不兼容。 今天的诊所OCP利用了往返测量中表现出的内在对称约束 使用OCT执行，这使得能够从先前的病态恢复偏振效应 配置，使现有的商业OCT仪器能够适应先进的组织 旋光测定法目标1将磁共振图像重建的概念整合到OCP中， 补偿有害的系统效应并抑制斑点引起的偏振噪声。目标2适应 OCP到使用单一光谱变化输入状态的商业临床血管内OCT仪器， 偏振多样化检测用于研究患者中的斑块破裂和愈合。目标3执行OCP， 视网膜OCT仪器使用单个光谱仪，依赖于旋转波片模块，安装到 为OCT血管造影建立了可访问的往返路径和重复扫描模式。RNFL双折射 将在青光眼患者和健康对照者中使用适应的临床仪器进行研究。 结合起来，这项工作将为临床OCT成像社区提供一个算法工具箱， 将现有的OCT仪器以最小的修改转换为强大的偏振成像平台。