Universal optical coherence polarimetry

通用光学相干偏振测定法

• 批准号: 10661749
• 负责人: Martin Villiger
• 金额: $ 47.77万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661749
• 关键词: Acute; Acute Coronary Event; Adoption; Algorithms; Angiography; Anisotropy; Arterial Fatty Streak; Atherosclerosis; Axon; Biological Markers; Birefringence; Blindness; Cadaver; Cardiac Catheterization Procedures; Catheters; Cause of Death; Clinic; Clinical; Clinical Research; Collaborations; Communities; Compensation; Coronary; Coronary Arteriosclerosis; Coronary artery; Custom; Data; Detection; Development; Diagnosis; Early Diagnosis; Eye; Fiber; Fiber Optics; Future; Glaucoma; Goals; Heart; Image; Imaging Device; Infrastructure; Intervention; Investigation; Light; Lighting; Lung; Magnetic Resonance Imaging; Mammary Neoplasms; Measurement; Measures; Medical; Methods; Modification; Monitor; Myocardial Infarction; Neurodegenerative Disorders; Noise; Ophthalmology; Optical Coherence Tomography; Optics; Patients; Pattern; Pilot Projects; Property; Recovery; Research; Resolution; Retina; Retinal Ganglion Cells; Rotation; Rupture; Scanning; Sclera; Signal Transduction; Structure; Syndrome; System; Thinness; Tissues; United States; Validation; Variant; Vision; Work; axonal degeneration; base; clinical application; clinical imaging; clinical translation; coronary event; cost; denoising; economic cost; empowerment; healing; image reconstruction; imaging capabilities; imaging modality; imaging platform; improved; insight; instrument; lung imaging; novel; open source; optical fiber; percutaneous coronary intervention; polarimetry; preservation; prevent; prototype; reconstruction; response; retinal imaging; retinal nerve fiber layer; signal processing

Project Summary The goal of this research is to enable the integration of advanced polarimetric imaging into existing optical coherence tomography (OCT) hardware and expedite its clinical translation. OCT is essential in contemporary ophthalmology and is routinely used to guide percutaneous coronary interventions. Extending OCT to measure polarization effects arising from tissue anisotropy affords contrast between tissues that are indiscernible in OCT’s conventional scattering signal. Polarization provides insight into the make-up and physical orientation of tissue microstructure beyond the spatial resolution of OCT. Intravascular polarimetry with polarization-sensitive (PS)-OCT offers refined insight into coronary atherosclerosis in patients suffering from myocardial infarction and other coronary syndromes and may improve patient management and guidance of percutaneous interventions. In the eye, PS-OCT has shown promise to detect alterations of the retinal nerve fiber layer (RNFL) that precede the degeneration of its retinal ganglion cell axons encountered in glaucoma, the leading cause of irreversible blindness. However, the dissemination of PS-OCT relies on adoption by a wider community, which has been hindered by the excessive hardware complexity of conventional PS-OCT. This project develops a universal and robust signal processing framework for optical coherence polarimetry (OCP) that accommodates novel simplified hardware implementations. Coherent measurements of the polarization response to propagation through tissue conventionally require polarization-diverse detection and illumination with two input states. To avoid the acute complexity of multiplexing two input states, prototype PS- OCT systems currently employed for imaging the coronary arteries or the lung use sequential input modulation. Still, this remains incompatible with the substantial commercial OCT instrument infrastructure available in the clinic today. OCP capitalizes on an intrinsic symmetry constraint manifesting in round-trip measurements performed with OCT, which enables the recovery of polarization effects from previously ill-conditioned configurations and enables adaptation of existing commercial OCT instruments to perform advanced tissue polarimetry. Aim 1 integrates concepts from magnetic resonance image reconstruction into OCP to compensate for detrimental system effects and suppress speckle-induced polarization noise. Aim 2 adapts OCP to commercial clinical intravascular OCT instruments using a single, spectrally varying input state and polarization diverse detection for investigating plaque rupture and healing in patients. Aim 3 performs OCP with retinal OCT instruments using a single spectrometer, relying on a rotating waveplate module, fitted into the accessible round-trip path and repeated scan patterns established for OCT angiography. RNFL birefringence will be investigated with the adapted clinical instruments in glaucoma patients and healthy controls. Combined, this work will provide the clinical OCT imaging community with a toolbox of algorithms that transforms existing OCT instruments with minimal modification into powerful polarimetric imaging platforms.

项目摘要 这项研究的目标是使先进的偏振成像能够集成到现有的光学系统中 相干断层扫描(OCT)硬件，并加快其临床翻译。OCT在当代是必不可少的 眼科和常规用于指导经皮冠状动脉介入治疗。将OCT扩展到测量 由组织各向异性引起的极化效应提供了组织之间的对比，这些组织在 OCT的常规散射信号。极化提供了对组成和物理方向的洞察 组织微结构超出OCT的空间分辨率。偏振灵敏的血管内旋光法 (PS)-OCT提供对心肌梗死患者冠状动脉粥样硬化的精细洞察 和其他冠状动脉综合征，并可能改善患者的管理和经皮冠状动脉介入治疗的指导 干预措施。在眼睛方面，PS-OCT显示出检测视网膜神经纤维层变化的前景 (RNFL)是青光眼中视网膜神经节细胞轴突变性的先兆，主要的 导致不可逆转的失明。然而，PS-OCT的传播依赖于更广泛的 传统PS-OCT的硬件复杂度过高，阻碍了这一进程。 该项目为光学相干偏振测量开发了一个通用的、健壮的信号处理框架 (OCP)，适应新颖的简化硬件实施。相干性测量 对通过组织传播的偏振响应传统上需要偏振多样化检测 具有两个输入状态的照明。为了避免多路复用两个输入状态的严重复杂性，原型PS- 目前用于冠状动脉或肺成像的OCT系统使用顺序输入调制。 尽管如此，这仍然与OCT可用的大量商业仪器基础设施不兼容 今天去诊所。OCP利用了在往返测量中表现出来的内在对称性约束 使用OCT执行，这使得能够从先前病态的偏振效果中恢复 配置并使现有的商业OCT仪器能够进行先进的组织 旋光法。AIM 1将磁共振图像重建的概念集成到OCP中，以 补偿有害的系统影响并抑制散斑激发的极化噪声。AIM 2改编 OCP到商用临床血管内OCT仪器使用单一、光谱变化的输入状态 偏振多元化检测在研究患者斑块破裂和愈合中的作用。AIM 3通过以下方式执行OCP 视网膜OCT仪器使用单个光谱仪，依靠旋转的波片模块，安装在 为OCT血管造影术建立可访问的往返路径和重复扫描模式。RNFL双折射 将在青光眼患者和健康对照组中使用适应的临床仪器进行调查。 结合起来，这项工作将为临床OCT成像社区提供一个算法工具箱， 将现有的OCT仪器转变为功能强大的偏振成像平台，只需进行最小的修改。