Characterization of sarcopenia in heart failure by T1rho magnetic resonance fingerprinting

T1rho 磁共振指纹图谱表征心力衰竭中的肌肉减少症

• 批准号: 10661101
• 负责人: Brendan Lee Eck
• 金额: $ 13.89万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661101
• 关键词: Address; Affect; Aging; Assessment tool; Biological Assay; Biology; Biology of Aging; Biopsy; Biopsy Specimen; Blood capillaries; Cardiac; Cardiopulmonary; Career Mobility; Characteristics; Chronic Disease; Chronology; Clinical; Clinical Management; Clinical assessments; Consumption; Deposition; Deterioration; Development; Development Plans; Diabetes Mellitus; Disease; Doctor of Philosophy; Dual-Energy X-Ray Absorptiometry; Edema; Elderly; Evaluation; Exhibits; Fatty acid glycerol esters; Fiber; Fibrosis; Fingerprint; Functional disorder; General Population; Goals; Hand Strength; Heart; Heart failure; Hypertension; Image; Imaging Device; Imaging technology; Impairment; Individual; Interdisciplinary Study; Knowledge; Link; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mentorship; Metabolic; Methods; Mitochondria; Morphologic artifacts; Muscle; Muscle function; Muscular Atrophy; Myocardial tissue; Myocardium; Noise; Organ; Outcome; Pathologic; Pathway interactions; Patients; Performance; Population; Process; Property; Proteins; Quality of life; Questionnaires; Relaxation; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Rotation; Scanning; Site; Skeletal Muscle; Techniques; Technology; Testing; Thigh structure; Time; Tissues; Training; Walking; X-Ray Computed Tomography; aging population; biomedical imaging; bone imaging; cardiac magnetic resonance imaging; cardiovascular imaging; career development; density; frailty; grasp; healthy volunteer; heart imaging; human subject; improved; in vivo evaluation; insight; mitochondrial dysfunction; mortality; muscle form; novel; programs; research study; sarcopenia; simulation; skeletal muscle wasting; skills; tool

Project Summary The goals of this proposal are to develop a novel quantitative magnetic resonance imaging (MRI) technology for characterization of sarcopenia, loss of skeletal muscle mass and function, in heart failure (HF) and support the career development of the investigator, Brendan Eck, PhD, in aging and biomedical imaging research. Research: Sarcopenia in HF is independently predictive of poor outcomes. Although primary sarcopenia is a condition of aging, rates of sarcopenia in HF are greater than the general population. Pathophysiological mechanisms in the heart and skeletal muscle have been identified that link HF and sarcopenia. Current tools for assessing sarcopenia in HF are indirect or are not sensitive to alterations in skeletal muscle that occur early in disease. Quantitative MRI can provide tissue property measurements that are potentially sensitive to pathological changes in skeletal muscle. However, existing techniques are impracticably slow or not reproducible. MR fingerprinting (MRF) has developed as a rapid, reproducible technique for quantification of multiple tissue properties. However, quantitative T1rho, a measure sensitive to alterations in protein content, has only recently been shown to be quantifiable by MRF with no study of its use in sarcopenia. This project aims to develop T1rho-MRF to simultaneously quantify T1rho and other MRF-derived skeletal muscle properties. T1rho-MRF will also be developed for cardiac imaging to investigate tissue alterations affecting both skeletal muscle and myocardium in sarcopenia with HF. In Aim 1 of the project, the T1rho-MRF technology will be developed and optimized in simulations. T1rho-MRF will be validated in physical phantoms and in human subjects. Skeletal muscle biopsy will also be acquired and T1rho-MRF will be compared to tissue properties such as fiber type proportion. In Aim 2, healthy controls and HF patients, with sarcopenia and without sarcopenia, will be scanned with T1rho-MRF. Quantitative values will be compared between groups to characterize HF patients with sarcopenia. T1rho-MRF measurements will be correlated with function from grip strength, 6-minute walk, and cardiopulmonary tests. Career development: The investigator has a technical background in quantitative cardiovascular imaging and aims to transition to aging and biomedical imaging research. This research project develops critical skills and knowledge for the investigator’s career development. The career development plan provides training in biology of aging, biology of skeletal muscle, engagement with clinicians to understand clinical assessments of sarcopenia in HF, and imaging research study design and execution. Training includes both didactic and experiential components. A diverse mentorship team, consultant, and collaborators contribute complementary skills toward developing the candidate’s interdisciplinary research program. Summary: The proposal will provide novel imaging tools to assess sarcopenia in HF and support the career development of the investigator to become an independent researcher in aging and biomedical imaging.

项目摘要 该提案的目标是开发一种新型的定量磁共振成像（MRI）技术 为了表征肌肉减少症，骨骼肌质量和功能的丧失，心力衰竭（HF）和支持 调查员Brendan Eck，PhD的职业发展，在衰老和生物医学成像研究中。 研究：HF中的肌肉减少症独立预测不良结果。虽然原发性肌肉减少症是 衰老的状况，HF的肌肉减少症大于一般人群。病理生理 已经确定了将HF和肌肉减少症连接的心脏和骨骼肌的机制。当前工具 用于评估HF中的肌肉减少症是间接的，或者对早期发生的骨骼肌的改变不敏感 在疾病中。定量MRI可以提供潜在敏感的组织特性测量 骨骼肌的病理变化。但是，现有技术在不切实际上很慢还是不慢 可再现。 MR指纹（MRF）已开发为一种快速，可再现的技术，用于定量 多个组织特性。但是，定量T1rho，一种对蛋白质含量改变敏感的度量， 直到最近才显示出MRF可以量化，而没有研究其在肌肉减少症中的使用。这个项目 旨在开发T1RHO-MRF，以简单地量化T1RHO和其他MRF衍生的骨骼肌肉 特性。 T1rho-MRF也将用于心脏成像，以研究影响组织改变的组织变化 HF的骨骼肌肉和心肌均骨骼肌和心肌。在该项目的AIM 1中，T1rho-Mrf 技术将在模拟中开发和优化。 T1RHO-MRF将在物理幻象上进行验证 和人类主题。还将获得骨骼肌活检，并将T1rho-MRF与 组织特性，例如纤维类型特性。在AIM 2中，健康的对照和HF患者，患有肌肉减少症和 没有肌肉减少症，将使用T1RHO-MRF进行扫描。分组之间将比较定量值 表征HF肌肉减少症患者。 T1RHO-MRF测量将与Grip的功能相关 强度，步行6分钟和心肺测试。 职业发展：研究人员在定量心血管成像和 旨在过渡到衰老和生物医学成像研究。该研究项目发展了关键技能， 研究人员的职业发展知识。职业发展计划提供生物学培训 衰老，骨骼肌生物学，与临床医生的互动以了解 HF中的肌肉减少症以及成像研究设计和执行。培训包括教学和 专家组件。一个潜水员精明的团队，顾问和合作者贡献完善 制定候选人的跨学科研究计划的技能。 摘要：该提案将提供新颖的成像工具来评估HF的肌肉减少症并支持职业 研究人员的发展成为衰老和生物医学成像领域的独立研究人员。