Regenerative Ultramicroelectrode arrays for sensory-motor specific interfacing
Regenerative Ultramicroelectrode arrays for sensory-motor specific interfacing
批准号:
10661741
负责人:
Mario Ignacio Romero-Ortega
金额:
$55.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-01 至 2026-06-30
关键词:
AccelerationAdultAfferent NeuronsAgingAmputationAmputeesAnimalsAreaAxonBiomedical EngineeringBionicsChargeChemicalsCuesCutaneousDataDeteriorationDevicesDiameterDistalElbowElectric StimulationElectrodesElectromyographyElectron MicroscopyEngineeringEsthesiaFailureFreedomGrowth FactorHandHistologyHumanImplantIndividualIntuitionLimb ProsthesisLimb structureLocomotionMapsMeasurementMechanicsMethodsModalityModelingMolecularMorphologic artifactsMotionMotorMotor CortexMovementMuscleNatural regenerationNerveParaplegiaPathway interactionsPatientsPatternPeriodicityPeripheralPeripheral NervesPeripheral Nervous SystemPersonsPhysiologyPopulationPositioning AttributePropertyProprioceptionProsthesisRattusReadingRoboticsSensoryShapesSignal TransductionSiteSkinSomatosensory CortexSpectrum AnalysisSting InjuryStructure of ulnar nerveSurfaceTactileTestingThalamic structureTimeTouch sensationTrainingTranslatingUnited StatesUpper ExtremityUtahViralVisualarmbasecognitive loaddesignefficacy evaluationelectric impedanceexperimental groupglial cell-line derived neurotrophic factorgraspimprovedinnovationkinematicslimb losslimb movementmechanical propertiesmedian nervemetermicrostimulationmotor controlmulti-electrode arraysneuralneuroprosthesisneurotransmissionnovel strategiespleiotrophinpowered prosthesisprosthesis controlregenerativeresidual limbresponserobot controlsciatic nervesensorsensory feedbacksilicon carbidesomatosensorytreadmillvisual feedbackvoltage
中文摘要
项目摘要
全球约有400万截肢者,这一数字估计每年增长20万。上肢
截肢者传统上使用被动的、身体动力的或使用表面的电动假体。
残肢运动的完整肌肉的肌电(EMG)信号,尽管
运动伪影、可变性以及用户对视觉和/或替代感觉控制的需求。进阶
外周神经系统(PNS)接口已被提出作为一种可行的机制来改善
由截肢者控制,通过阅读来自机器人假肢的自然主义感官反馈。不幸的是,
目前的神经接口面临着共同的挑战,电极失效,信号恶化
时间、肌电污染、电和不稳定的感官知觉,包括“刺痛或刺痛”仍然存在
这是一个挑战。这项研究使用了两种新的策略,旨在增加对
PNS界面的记录/刺激:1)使用创新的再生多电极
使用我们最新开发的超薄多电极阵列与超小型记录点对接,以及
2)结合分子引导线索来影响神经上感觉神经元的类型
界面。这种选择性再生超微多电极阵列(RUMEA)旨在
结合分子引导辨别运动和皮肤神经对接
生物工程的内容的感觉-运动轴突在电极界面。三个具体目标
包括:在SA1336电极RUMA中,将制造直型和Y型器件,并
进行了电化学和机械测试。在SA2中,我们试图演示来自马达的选择性录音
轴突,并用鲁玛唤起触觉。在SA3中,我们将演示选择性接口
大鼠上肢截肢后的运动和触觉轴突双向神经机接口模型
分子引导的鲁马斯。如果成功,这一策略将展示将RUMA用于
运动轴突的选择性记录,以及刺激感觉通道轴突,唤起自然主义
感官知觉。截肢者周围神经接口的这种进步将降低认知能力
机器人假肢使用者的负担,并减少与电子设备相关的异常感觉
三叉神经节的刺激。
英文摘要
Project Summary
Approximately 4 million amputees globally, a number estimated to grow 200,000 annually. Upper limb
amputees traditionally use passive, body powered, or electrically powered prostheses that use surface
Electromyographic (EMG) signals from intact muscles in the residual limb for movement, despite the
motion artifacts, variability and need of visual and/or surrogate sensory control by the user. Advanced
peripheral nervous system (PNS) interfaces have been proposed as a viable mechanism to improve the
control by amputees, by reading naturalistic sensory feedback from the robotic prosthetics. Unfortunately,
current neural interfaces suffer from common challenges, and electrode failure, signal deterioration over
time, EMG contamination and electrical and unstable sensory percepts, including “stings or tingles” remain
a challenge. This study is uses two novel strategies designed to increase the selectivity of
recording/stimulation at the PNS interface: 1) The use of an innovative regenerative multi-electrode
interface with ultra-small recording sites using our recently developed ultra-thin multielectrode array , and
2) incorporation of molecular guidance cues to influence the type of sensory neurons at the neural
interface. This selectivity Regenerative Ultramicro Multielectrode Array (RUMEA) is designed to
discriminate between motor and cutaneous neural interfacing by combining it with molecular guidance to
biologically engineer the content of sensory-motor axons at the electrode interface. Three specific aims
are included: In SA1 36-electrode RUMAs, straight and Y-shape devices, will be fabricated and
electrochemical and mechanical tested. In SA2 we seek to demonstrate selective recording from motor
axons and evoke touch percepts using the RUMA. In SA3, we will demonstrate selective interfacing of
motor and tactile axons in an upper limb amputee rat model of bidirectional Nerve Machine Interface using
molecularly guided RUMAs. If successful, this strategy will demonstrate the benefit for using RUMA for
selective recording from motor axons, and stimulation of sensory modality axons that evoke naturalistic
sensory percepts. This advancement in peripheral neural interfaces for amputees, will reduce the cognitive
burden for users of robotic prosthetics, and decrease the abnormal sensations associated with electrical
stimulation in the PNS.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Controlled Gradient Release of Biologics: Enhanced Nerve Conduit for Long‐Gap Injury Repair
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批准号:10603563
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项目类别:
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资助金额:$42.2万
-
财政年份:2023
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负责人:Mario Ignacio Romero-Ortega
-
依托单位:
Regenerative Ultramicroelectrode arrays for sensory-motor specific interfacing
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批准号:10317852
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项目类别:
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资助金额:$58.53万
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财政年份:2021
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负责人:Mario Ignacio Romero-Ortega
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依托单位:
Regenerative Ultramicroelectrode arrays for sensory-motor specific interfacing
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批准号:10475261
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项目类别:
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资助金额:$56.07万
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财政年份:2021
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负责人:Mario Ignacio Romero-Ortega
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依托单位:
Neuromodulation of Individual Pelvic Floor Muscle Activity in Urinary Incontinence
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批准号:10250561
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项目类别:
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资助金额:$54.16万
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财政年份:2020
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负责人:Mario Ignacio Romero-Ortega
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依托单位:
Neuromodulation of Individual Pelvic Floor Muscle Activity in Urinary Incontinence
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批准号:9790960
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项目类别:
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资助金额:$52.94万
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财政年份:2018
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负责人:Mario Ignacio Romero-Ortega
-
依托单位:
Neuromodulation of Individual Pelvic Floor Muscle Activity in Urinary Incontinence
-
批准号:9686834
-
项目类别:
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资助金额:$56.04万
-
财政年份:2018
-
负责人:Mario Ignacio Romero-Ortega
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依托单位:
Long-Gap Nerve Regeneration by Pleiotrophic Support in Multiluminal Grafts
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批准号:8196684
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项目类别:
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资助金额:$20.95万
-
财政年份:2011
-
负责人:Mario Ignacio Romero-Ortega
-
依托单位:
Long-Gap Nerve Regeneration by Pleiotrophic Support in Multiluminal Grafts
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批准号:8306757
-
项目类别:
-
资助金额:$18.18万
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财政年份:2011
-
负责人:Mario Ignacio Romero-Ortega
-
依托单位:
海外基金