Pilot/Exploratory Studies Core (PESC)

摘要 西北老年美国人独立的首要目标 中心(OAIC，又名胡椒中心)将产生创新的研究，以 加强对医疗复杂、患有多发性慢性阻塞性肺疾病的老年人的初级保健 条件(MCC)，以实现最佳的健康、独立和生活质量。 试点/探索性研究核心(PESC)将在战略上与 研究教育部分(REC)，以i)确定、选择和资助初级 教职员工，与MCC相关的兴趣老化的实习生；ii)导师， 通过一个令人敬畏的研究项目支持和监督学者们 为他们提供足够的初步数据，以帮助他们证明更大、更独立 批准建议，并成功地推进他们的事业。 PESC的具体目标是： 目标1资助、启动和实施第一波试点/探索性研究(PES 1-3)，以吸引初级 西北大学OAIC研究企业的调查人员和产生创新研究的设计 以改善患有MCC的美国老年人的功能和生活质量。 目标2实施一个程序，通过该程序，西北OAIC将征集、同行审查、选择和确定优先次序， 在西北OAIC的头5年内，支持和监测至少9个PES。 目标3鼓励利用胡椒奖学金开发有竞争力的外部赠款申请 PES和其他人在西北大学、芝加哥和整个OAIC网络做相关工作。 我们的西北OAIC将在1-3年内奖励三波PES资金(最少9个奖项，至少3个 年)；中心领导举行试点项目竞争性征集，确定了第一波辣椒 学者PES：1)改善护理从熟练护理机构到社区的过渡(特里萨博士 Rowe，老年病学助理教授)；2)智能个人助理 待在家里的老年人(Katherine O‘Brien博士，老年病学助理教授)；3)急诊科 以停药干预为基础的老年MCC患者(急诊助理教授Howard Kim博士 医学)。PESC将利用西北大学临床研究所开发的流程和系统 和翻译科学研究所(NUCATS)管理2年级和3年级的PES竞赛；项目收到 借助我们的OAIC资源核心提供的实物方法支持，两年内直接成本最高可达100,000美元 (设计、测量、分析)。我们的实习生“流水线”现在延伸到其他学术机构(UIC、Rush)。 我们的信息传播核心还将帮助胡椒学者广泛传播PES研究结果。

ABSTRACT The overarching goal of the Northwestern Older Americans Independence Center (OAIC, a.k.a. `Pepper Center') is to generate innovative research to enhance primary care for medically complex, older adults with multiple chronic conditions (MCC) to achieve optimal health, independence, and quality of life. The Pilot/Exploratory Studies Core (PESC) will be strategically linked to the Research Education Component (REC), to i) identify, select, and fund junior faculty, `Pepper Scholar' trainees with aging interests related to MCC; ii) mentor, support and monitor Scholars through a formidable research project that will provide them with sufficient preliminary data to help justify larger, independent grant proposals and successfully advance their career. The specific aims of the PESC are to: Aim 1 Fund, initiate, and conduct a first wave of Pilot/Exploratory Studies (PES 1-3) that will engage junior investigators in Northwestern's OAIC research enterprise and generate innovative research designed to improve function and quality of life for older Americans with MCC. Aim 2 Implement a process by which the Northwestern OAIC will solicit, peer-review, select and prioritize, support, and monitor at least 9 PES in the first 5 years of the Northwestern OAIC. Aim 3 Encourage the development of competitive, external grant applications leveraging Pepper Scholar PES and others doing related work at Northwestern, in Chicago and throughout the OAIC Network. Our Northwestern OAIC will award three waves of PES funding in Years 1-3 (minimum 9 awards, at least 3 per year); Center leadership held a competitive solicitation for pilot projects and have identified the 1st wave of Pepper Scholar PES: 1) Improving Transitions of Care from Skilled Nursing Facilities to the Community (Dr. Theresa Rowe, Assistant Professor, Geriatrics); 2) Intelligent Personal Assistant Depression Management for Homebound Older Adults ((Dr. Katherine O'Brien, Assistant Professor, Geriatrics); 3) An Emergency Department -based Deprescribing Intervention for Older Adults with MCC (Dr. Howard Kim, Assistant Professor, Emergency Medicine). The PESC will leverage processes and systems developed by the Northwestern University Clinical and Translational Sciences Institute (NUCATS) to manage PES competitions in Years 2 and 3; projects receive up to $100,000 direct costs over 2 years with in-kind methodological support from our OAIC Resource Cores (Design, Measurement, Analytics). Our trainee `pipeline' now extends to other academic institutions (UIC, Rush). Our Information Dissemination Core will also aid Pepper Scholars in widely disseminating PES findings.