Nathan Shock Center of Excellence in Basic Biology of Aging

总体项目摘要 此申请是为了更新的内森休克卓越中心在衰老的基础生物学 在华盛顿大学及其附属机构。该中心在过去25年中 为研究衰老生物学的研究人员提供了关键资源。本申请 继续强调向最广泛的调查人员群体提供外联和服务的主题 在老年科学中。与此密切相关的是衰老相关表型的特征， 长寿和健康。由于我们的中心服务必须易于外部用户访问， Longevity and Healthspan Core（核心E）专注于无脊椎动物检测，其中许多是新颖的。两 其他资源核心集中于与老化密切相关的高维评估 表型：衰老蛋白表型（核心C）和衰老代谢物表型（核心D）。 提供了用于数据分析和最佳洞察的复杂计算和生物信息学工具 人工智能和生物信息学核心F。这四个资源核心中的每一个都由 该领域备受尊敬的专家，包括Michael MacCoss和Judit Villen（核心C）、丹尼尔 Promislow（核心D），Matt Kaeberlein和Maitreya Dunham（核心E）和Su-In Lee（核心F）。每个 将推动适当的技术，开发新的最先进的方法， 最适用于老年学的评估，并使其可供国家 老龄化社区研究发展核心（核心B）将继续支持试点和初级 教师的研究，与服务的国家老年科学选区的坚定重点外展。的 行政和计划充实核心（核心A）支持行政管理， 外部咨询小组、课程以及数据共享和传播。核心A的研讨会方案 和专题讨论会将继续把重点放在赞助和组织国家课程、会议 和会前会议，以及与我们的资源核心服务相关的领域的研讨会。在 与其他内森休克中心协调，我们将支持一项新的老年病理学研究 倡议

OVERALL PROJECT SUMMARY This application is for renewal of the Nathan Shock Center of Excellence in the Basic Biology of Aging at the University of Washington and affiliated institutions. This Center has over the past 25 years provided key resources in support of investigators who study the biology of aging. This application continues a theme that emphasizes outreach and service to the broadest community of investigators in the gerosciences. Of proximal relevance is the characterization of aging-related phenotypes of longevity and healthspan. As our Center services must be easily accessible to outside users, our Longevity and Healthspan Core (Core E) focuses on invertebrate assays, many of them novel. Two other Resources Cores focus on the high dimensional assessments that are closely related to aging phenotypes: Protein Phenotypes of Aging (Core C) and Metabolite Phenotypes of Aging (Core D). Sophisticated computational and bioinformatic tools for data analysis and optimal insight are provided by the Artificial Intelligence and Bioinformatics Core F. Each of these four Resource Cores is led by highly respected experts in that field, including Michael MacCoss and Judit Villen (Core C), Daniel Promislow (Core D), Matt Kaeberlein and Maitreya Dunham (Core E) and Su-In Lee (Core F). Each will push the envelope of appropriate technologies, developing new state-of-the art approaches for assessments that are the most applicable to gerontology and making them accessible to the national aging community. The Research Development Core (Core B) will continue to support pilot and junior faculty studies, with a firm focus on outreach of service to the national geroscience constituency. The Administrative and Program Enrichment Core (Core A) supports administrative management, an external advisory panel, courses, and data sharing and dissemination. Core A’s program of seminars and symposia will continue a focus on sponsorship and organization of national courses, meetings and pre-meetings, as well as workshops in the fields allied to our Resource Core Services. In coordination with other Nathan Shock Centers, we will support a new Geropathology Research initiative.