Core E: Invertebrate Longevity and Healthspan
Core E: Invertebrate Longevity and Healthspan
批准号:
10670105
负责人:
Alexander Richard Mendenhall
金额:
$15.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
未结题
起止时间:
1997-07-15 至 2025-05-31
关键词:
AgeAgingAnimalsAreaBiochemicalBiologicalBiological AssayBiology of AgingBiomedical ResearchCaenorhabditis elegansCellsChronologyCollaborationsColorCommunitiesComplexComputer AnalysisDataDevelopmentDevicesDiseaseEducation and OutreachFluorescence MicroscopyFundingGoalsHistonesHourIndividualInvertebratesLabelLeftLongevityMeasuresMethodologyMethodsMicrofluidicsModelingModificationMolecularMothersMovementMutationNematodaNuclear PorePerceptionPhenotypePilot ProjectsPopulationProcessProteinsReporterResearchResearch PersonnelResolutionResourcesRoboticsSaccharomyces cerevisiaeSaccharomycetalesSamplingSchemeServicesShockTechnologyTimeTrainingWorkYeastsage relatedaging populationbehavioral phenotypingcell ageexperimental studygenetic selectionhealthspanhigh dimensionalityinnovationinterestlearning materialslight microscopymagnetic beadsmicroscopic imagingmodel organismmovienew technologynovel strategiesoptical spectrarobotic systemtool
中文摘要
核心:无脊椎动物长寿与健康-摘要/摘要
英文摘要
CORE E: INVERTEBRATE LONGEVITY AND HEALTHSPAN – SUMMARY/ABSTRACT
This Core will assist investigators throughout the research community in quantifying a variety of longevity and
healthspan measures in two of the major invertebrate model organisms: the budding yeast Saccharomyces
cerevisiae and the nematode Caenorhabditis elegans. This will be accomplished through direct collaboration,
training and outreach, and the development and dissemination of new tools and technologies. New
technologies we have developed and will disseminate include microfluidic tools for invertebrate aging studies
and the WormBot, a robotic system for high-throughput survival and behavioral phenotyping in C. elegans. We
will also work to develop chemostat-based solutions for obtaining age-matched pure populations of yeast for
biochemical and cell biological experiments requested by Core users. The focus on yeast and worms allows
us to provide services and technologies to a large number of external investigators and thereby have a
correspondingly large impact. The data generated by this Core can be correlated with high dimensional
computational analyses (Core F) and with the protein and metabolite phenotypes studied in Cores C and D,
respectively. Invertebrate models are also highly accessible to junior investigators, and Core B support for pilot
projects allows these investigators access to the full range of integrated services provided by the Center
Resource Cores.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Understanding the antagonistic role of proteostasis in Alzheimer disease and cancer.
-
批准号:10118671
-
项目类别:
-
资助金额:$37.57万
-
财政年份:2018
-
负责人:Alexander Richard Mendenhall
-
依托单位:
(PQ1) The role of cell-to-cell variation in the penetrance of heritable mutant RAS hypodermal neoplasias
-
批准号:10245157
-
项目类别:
-
资助金额:$36.85万
-
财政年份:2018
-
负责人:Alexander Richard Mendenhall
-
依托单位:
(PQ1) The role of cell-to-cell variation in the penetrance of heritable mutant RAS hypodermal neoplasias
-
批准号:10471967
-
项目类别:
-
资助金额:$36.12万
-
财政年份:2018
-
负责人:Alexander Richard Mendenhall
-
依托单位:
(PQ1) The role of cell-to-cell variation in the penetrance of heritable mutant RAS hypodermal neoplasias
-
批准号:9592073
-
项目类别:
-
资助金额:$39.76万
-
财政年份:2018
-
负责人:Alexander Richard Mendenhall
-
依托单位:
Causes and consequences of lifespan biomarker variation in Caenorhabditis elegans
-
批准号:9282763
-
项目类别:
-
资助金额:$24.9万
-
财政年份:2016
-
负责人:Alexander Richard Mendenhall
-
依托单位:
海外基金