Core E: Invertebrate Longevity and Healthspan

核心E：无脊椎动物的长寿和健康跨度-摘要/摘要 这一核心将帮助整个研究界的研究人员量化各种长寿和 两种主要无脊椎动物模式生物：芽生酵母的健康寿命测量 Cerevisiae和线虫Canowhabditis elegans。这将通过直接合作实现， 培训和外联，以及新工具和技术的开发和传播。新的 我们已经开发并将推广的技术包括用于无脊椎动物衰老研究的微流控工具 还有WormBot，这是一种用于线虫高通量生存和行为表型的机器人系统。我们 还将致力于开发基于恒化器的解决方案，以获得年龄匹配的纯酵母种群 应核心用户的要求进行生化和细胞生物学实验。对酵母和蠕虫的关注使得 美国向大量外部调查人员提供服务和技术，从而拥有 相应地，影响也很大。该核产生的数据可以与高维数据相关联 计算分析(核心F)，并在核心C和D研究蛋白质和代谢物表型， 分别进行了分析。初级调查人员也可以高度访问无脊椎动物模型，并为飞行员提供核心B支持 项目使这些调查人员能够获得该中心提供的全方位综合服务 资源核心。

CORE E: INVERTEBRATE LONGEVITY AND HEALTHSPAN – SUMMARY/ABSTRACT This Core will assist investigators throughout the research community in quantifying a variety of longevity and healthspan measures in two of the major invertebrate model organisms: the budding yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. This will be accomplished through direct collaboration, training and outreach, and the development and dissemination of new tools and technologies. New technologies we have developed and will disseminate include microfluidic tools for invertebrate aging studies and the WormBot, a robotic system for high-throughput survival and behavioral phenotyping in C. elegans. We will also work to develop chemostat-based solutions for obtaining age-matched pure populations of yeast for biochemical and cell biological experiments requested by Core users. The focus on yeast and worms allows us to provide services and technologies to a large number of external investigators and thereby have a correspondingly large impact. The data generated by this Core can be correlated with high dimensional computational analyses (Core F) and with the protein and metabolite phenotypes studied in Cores C and D, respectively. Invertebrate models are also highly accessible to junior investigators, and Core B support for pilot projects allows these investigators access to the full range of integrated services provided by the Center Resource Cores.