A novel role for higher order auditory circuits: social group dynamics and descending pathways to the Social Behavior Network

高阶听觉回路的新作用：社会群体动态和社会行为网络的下降路径

• 批准号: 10671537
• 负责人: Jeremy Spool
• 金额: $ 11.6万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10671537
• 关键词: 3-Dimensional; Ablation; Animals; Area; Auditory; Auditory area; Behavior; Behavioral; Brain; Brain region; Cell Nucleus; Cells; Cognition; Cognitive; Complex; Critical Pathways; Data; Decision Making; Disease; Dissection; Ecology; Electrophysiology (science); Environment; Evaluation; Failure; Familiarity; Food deprivation (experimental); Foundations; Future; Genetic; Goals; Hypothalamic structure; Impairment; Individual; Investigation; Knowledge; Lateral; Learning; Lesion; Link; Managed Competition; Measures; Mediating; Memory; Mentors; Motivation; Nature; Neural Pathways; Neuroendocrinology; Neurologic Symptoms; Neurosciences; Output; Pair Bond; Partner in relationship; Pathology; Pathway Analysis; Pathway interactions; Phase; Physiological; Play; Population; Process; Research; Role; Secondary to; Sensory; Site; Social Behavior; Social Controls; Social Interaction; Social Network; Social isolation; Speed; Stimulus; System; Techniques; Testing; Therapeutic; Training; Viral; Voice; approach behavior; auditory pathway; auditory processing; auditory thalamus; avoidance behavior; design; experimental study; extracellular; in vivo; innovation; nervous system disorder; neural; neural circuit; neuropsychiatric disorder; novel; optogenetics; programs; response; small social group; social; social communication; social competition; social deficits; social group; social influence; social integration; therapy design; tool; vocalization; zebra finch

Project Summary/Abstract Healthy social group living relies heavily on the ability to process complex sensory environments. In several prevalent neurological and neuropsychiatric disorders, deficits in social interactions are frequently associated with pathology in auditory circuits. Broad lesions of higher auditory circuits result in alterations in social behavior. Despite a strong connection between auditory cognition and social behavior, we lack basic knowledge about how higher auditory circuits influence social group dynamics. The long-term goal of this proposal is to provide enhanced training that will enable the applicant to establish mechanisms by which higher auditory circuits support integration into social groups at behavioral and neural levels. Aims in this proposal will test the extent to which higher auditory pathways are critical for social group living through investigation of their role in complex group dynamics and their neural circuit outputs to social behavior brain areas. In the K99 phase, Aim 1 will test the extent to which specific damage to the pathway between primary and secondary auditory pallium (caudomedial nidoapllium, NCM) modifies approach and avoidance behavior in pair bonds and small groups of animals during social group formation. Preliminary data demonstrate that descending neural pathways from higher auditory areas modify social auditory processing in a social behavior nucleus, the lateral ventromedial nucleus of the hypothalamus (VMHl). Thus, Aim 2 will test the extent to which electrophysiological signatures of auditory memory (which is critical during social interactions) are represented in higher auditory NCM versus social behavior nucleus VMHl. During the mentored phase and in completion of the above Aims, the applicant will receive, in addition to novel conceptual training, comprehensive training implementing viral-mediated genetic ablation of neural pathways, automated behavioral analysis of complex social group dynamics, social network analysis, and multi-site in vivo electrophysiological recordings. In the R00 independent phase, the applicant will leverage this training to advance a research program that expands from study of single brain regions to synaptically-connected networks, and from individual behavior to large social group dynamics. Aims 3 & 4 will move forward to test the roles of descending pathways in the speed of integration into large social groups, and test the hypothesis that VMHl uses higher auditory circuit input to evaluate competing motivations (i.e., make decisions to engage in social versus non-social behaviors). The innovative approach of this proposal comes from the intersection of technical and conceptual advances in systems neuroscience, behavioral neuroendocrinology, and behavioral ecology using a highly gregarious study species, zebra finches, that constantly dissect complex auditory environments in large social groups. Expanding basic knowledge of mechanisms by which higher auditory pathways impact social group living can provide a critical foundation for future design of treatments for social symptoms of neurological and neuropsychiatric disorders.

项目摘要/摘要 健康的社会群体生活在很大程度上依赖于处理复杂感觉环境的能力。在几个月内 普遍的神经和神经精神障碍，社会互动的缺陷经常与 与听觉回路中的病理学有关。高级听觉回路的广泛损害会导致社会行为的改变。 尽管听觉认知和社会行为之间有很强的联系，但我们缺乏关于 高等听觉回路如何影响社会群体动态。这项提议的长期目标是提供 加强培训，使申请者能够建立高级听觉回路支持的机制 在行为和神经层面融入社会团体。这项提案中的目标将考验以下程度 通过对高级听觉通路在复杂群体中的作用的研究，发现高级听觉通路对社会群体生活至关重要 动力学及其神经回路输出到社会行为脑区。在K99阶段，Aim 1将测试 初级和次级听觉大脑皮层(尾内侧)之间通路的特异性损害程度 Nidoapllium，NCM)改变配对联系和小动物群体中的接近和回避行为 社会群体的形成。初步数据显示，来自高等听觉的下行神经通路 区域调节社会行为核中的社会听觉处理，社会行为核是 下丘脑(VMH1)。因此，目标2将测试听觉电生理特征的程度 记忆(在社会互动中是关键的)在更高的听觉NCM中表现出来，而不是社会 行为核VMHl。在指导阶段和完成上述目标时，申请者将 除了接受新的概念培训外，还接受全面的培训，实施病毒介导的遗传 神经通路消融、复杂社会群体动态的自动行为分析、社会网络 分析，并进行多点活体电生理记录。在R00独立阶段，申请人将 利用这一培训来推进研究计划，将研究从对单个大脑区域的研究扩展到 突触连接网络，从个人行为到大型社会群体动态。目标3和4将 继续测试下行路径在融入大型社会群体的速度中的作用，以及 测试以下假设：VMH1使用更高的听觉回路输入来评估相互竞争的动机(即 决定从事社会行为还是非社会行为)。这项提议的创新方法来自于 系统神经科学、行为神经内分泌学、 和行为生态学，使用一种高度群居的研究物种斑马雀，它不断地解剖复杂的 大型社会群体中的听觉环境。扩展关于高级机制的基本知识 影响社会群体生活的听觉通路可以为未来的治疗设计提供重要的基础 神经和神经精神障碍的社会症状。