A novel role for higher order auditory circuits: social group dynamics and descending pathways to the Social Behavior Network

高阶听觉回路的新作用：社会群体动态和社会行为网络的下降路径

• 批准号: 10671537
• 负责人: Jeremy Spool
• 金额: $ 11.6万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10671537
• 关键词: 3-Dimensional; Ablation; Animals; Area; Auditory; Auditory area; Behavior; Behavioral; Brain; Brain region; Cell Nucleus; Cells; Cognition; Cognitive; Complex; Critical Pathways; Data; Decision Making; Disease; Dissection; Ecology; Electrophysiology (science); Environment; Evaluation; Failure; Familiarity; Food deprivation (experimental); Foundations; Future; Genetic; Goals; Hypothalamic structure; Impairment; Individual; Investigation; Knowledge; Lateral; Learning; Lesion; Link; Managed Competition; Measures; Mediating; Memory; Mentors; Motivation; Nature; Neural Pathways; Neuroendocrinology; Neurologic Symptoms; Neurosciences; Output; Pair Bond; Partner in relationship; Pathology; Pathway Analysis; Pathway interactions; Phase; Physiological; Play; Population; Process; Research; Role; Secondary to; Sensory; Site; Social Behavior; Social Controls; Social Interaction; Social Network; Social isolation; Speed; Stimulus; System; Techniques; Testing; Therapeutic; Training; Viral; Voice; approach behavior; auditory pathway; auditory processing; auditory thalamus; avoidance behavior; design; experimental study; extracellular; in vivo; innovation; nervous system disorder; neural; neural circuit; neuropsychiatric disorder; novel; optogenetics; programs; response; small social group; social; social communication; social competition; social deficits; social group; social influence; social integration; therapy design; tool; vocalization; zebra finch

Project Summary/Abstract Healthy social group living relies heavily on the ability to process complex sensory environments. In several prevalent neurological and neuropsychiatric disorders, deficits in social interactions are frequently associated with pathology in auditory circuits. Broad lesions of higher auditory circuits result in alterations in social behavior. Despite a strong connection between auditory cognition and social behavior, we lack basic knowledge about how higher auditory circuits influence social group dynamics. The long-term goal of this proposal is to provide enhanced training that will enable the applicant to establish mechanisms by which higher auditory circuits support integration into social groups at behavioral and neural levels. Aims in this proposal will test the extent to which higher auditory pathways are critical for social group living through investigation of their role in complex group dynamics and their neural circuit outputs to social behavior brain areas. In the K99 phase, Aim 1 will test the extent to which specific damage to the pathway between primary and secondary auditory pallium (caudomedial nidoapllium, NCM) modifies approach and avoidance behavior in pair bonds and small groups of animals during social group formation. Preliminary data demonstrate that descending neural pathways from higher auditory areas modify social auditory processing in a social behavior nucleus, the lateral ventromedial nucleus of the hypothalamus (VMHl). Thus, Aim 2 will test the extent to which electrophysiological signatures of auditory memory (which is critical during social interactions) are represented in higher auditory NCM versus social behavior nucleus VMHl. During the mentored phase and in completion of the above Aims, the applicant will receive, in addition to novel conceptual training, comprehensive training implementing viral-mediated genetic ablation of neural pathways, automated behavioral analysis of complex social group dynamics, social network analysis, and multi-site in vivo electrophysiological recordings. In the R00 independent phase, the applicant will leverage this training to advance a research program that expands from study of single brain regions to synaptically-connected networks, and from individual behavior to large social group dynamics. Aims 3 & 4 will move forward to test the roles of descending pathways in the speed of integration into large social groups, and test the hypothesis that VMHl uses higher auditory circuit input to evaluate competing motivations (i.e., make decisions to engage in social versus non-social behaviors). The innovative approach of this proposal comes from the intersection of technical and conceptual advances in systems neuroscience, behavioral neuroendocrinology, and behavioral ecology using a highly gregarious study species, zebra finches, that constantly dissect complex auditory environments in large social groups. Expanding basic knowledge of mechanisms by which higher auditory pathways impact social group living can provide a critical foundation for future design of treatments for social symptoms of neurological and neuropsychiatric disorders.

项目摘要/摘要 健康的社会群体生活在很大程度上取决于处理复杂的感觉环境的能力。在几个 流行的神经和神经精神疾病，社交互动的缺陷经常相关 具有听觉电路中的病理学。较高听觉电路的广泛病变导致社会行为改变。 尽管听觉认知与社会行为之间有着密切的联系，但我们缺乏有关的基本知识 更高的听觉电路如何影响社会群体的动态。该提议的长期目标是提供 增强的培训将使申请人能够建立更高听觉电路支持的机制 在行为和神经层面上融入社会群体。在此提案中的目的将测试 较高的听觉途径对于通过调查其在复杂群体中的角色而生活的社会群体至关重要 动态及其神经回路向社会行为大脑区域输出。在K99阶段，AIM 1将测试 对主要听觉和次级听觉pallium之间的途径的特定损害的程度（尾部 nidoapllium，ncm）在成对键和小组动物中修改方法和回避行为 社会团体形成。初步数据表明，较高听觉的神经途径下降 区域修改社会行为核中的社会听觉处理，这是 下丘脑（VMHL）。因此，AIM 2将测试听觉的电生理特征的程度 记忆（在社交互动期间至关重要）在更高的听觉NCM与社交中表示 行为核VMHL。在指导阶段并完成上述目标时，申请人将 除了新颖的概念培训外，还接受了实施病毒介导的遗传的全面培训 神经通路的消融，复杂社会群体动态的自动行为分析，社交网络 分析和多部位体内电生理记录。在R00独立阶段，申请人将 利用这项培训来推进一项研究计划，该计划从对单一大脑区域的研究扩展到 突触连接的网络，从个人行为到大型社会群体动态。目标3和4将 向前迈进，测试降价途径在整合到大型社会群体速度中的作用， 测试VMHL使用较高听觉电路输入来评估竞争动机的假设（即 从事社交与非社会行为的决定。该提议的创新方法来自 系统神经科学，行为神经内分泌学的技术和概念进步的交集， 和使用高度社交研究物种斑马雀科的行为生态学，不断剖析复合​​物 大型社会群体的听觉环境。扩大对机制的基本知识 听觉途径影响社会群体的生活可以为未来设计的关键基础 神经和神经精神疾病的社会症状。