Free radical strategies for bioactive molecule synthesis-Diversity Supplement

项目摘要 通过我们在光和电化学方法方面的专业知识，拟议的工作将提供 与现代药物发现相关和感兴趣的新型分子支架。通过 利用这里描述的单电子方法，我们可以在之前生成 难以接近的饱和碳环化合物，有可能推进长期存在的挑战 在药物研发方面。通过配套的光化学方法，新的途径获得1- 氨基硼(1-氨基)、氨基环戊烷和双环[3.1.1]庚烷-1-胺 建立了一个强大的平台，从中探索新的碳环框架，如多样化的，SP3- 丰富的化学成分。亚胺光化学的基础研究 这些转化将产生碳环以外的进一步应用。交叉口 我们的光化学方法与过渡金属催化的反应提供了一种实用的 将所需的官能化(即饱和基序)引入无处不在的芳香族的方法 脊椎骨。最终，我们将利用单电子转换的力量来获得 到新的化学空间，我们相信它将在药物领域提供翻译机会 发现和更远的地方。

Project Summary Through our expertise in photo- and electrochemical methodology, the proposed work will afford novel molecular scaffolds relevant and of interest to modern drug discovery. Through the utilization of single-electron methodologies described herein, we can generate previously inaccessible saturated carbocylces that have the potential to advance long standing challenges within drug discovery. Through companion photochemical methodologies, novel access to 1- aminonobornanes (1-aminoNBs), aminocyclopentanes, and bicyclo[3.1.1]heptan-1-amines has established a robust platform from which to explore new carbocyclic frameworks as diverse, sp3- rich chemical building blocks. Fundamental investigations of the imine photochemistry underlying these transformations will yield further applications beyond carbocycle formation. The intersection of our photochemical methods with transition metal catalyzed reactions provides a practical means of introducing desirable functionality (i.e. saturated motifs) onto ubiquitous aromatic backbones. Ultimately, we will utilize the power of single-electron transformations to gain access to new chemical space which we are confident will afford translational opportunities in drug discovery and beyond.