Regulation of adrenal development and function by the mother's skeleton
母亲骨骼对肾上腺发育和功能的调节
基本信息
- 批准号:10671698
- 负责人:
- 金额:$ 34.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-23 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:ARHGEF5 geneAblationAcuteAdrenal CortexAdrenal GlandsAdrenal MedullaAdrenal gland hypofunctionAffectAldosteroneAnatomyAreaBindingBiochemicalBiological AssayBiologyBirthBrainCatecholaminesCellsChronicCirculationCognitionCorticosteroneCorticotropinDevelopmentDevelopmental ProcessElectrolytesEmbryoEndocrine GlandsEndocrinologyEpinephrineExhibitsFeedbackGeneticGlucocorticoidsGoalsGrowthHeterozygoteHippocampusHomeostasisHormonesHydrocortisoneIn VitroInjectionsInsulinMineralocorticoidsMolecularMonkeysMothersMusMutant Strains MiceOsteocalcinParentsPerinatal mortality demographicsPhenotypePhysiologicalPhysiological ProcessesPhysiologyPlacentaPlasmaPregnancyPrimatesProcessProductionRegulationReninRodentRoleSignal TransductionSkeletonSteroid biosynthesisSteroidsTestingTestosteroneTopical applicationVertebratesWild Type MouseZona FasciculataZona Glomerulosaadiponectinbaseblood pressure regulationboneexperimental studygain of functiongland developmentimprovedin vivoinhibitorloss of functionmouse geneticsmouse modelnoveloffspringpeptide hormonepostnatalreceptorsteroid hormone
项目摘要
PROJECT SUMMARY
The overall goal of this Application is to improve our understanding of the genetic and molecular control of
adrenal gland homeostasis by studying how osteocalcin originating from maternal skeleton, affects adrenal
growth and steroidogenesis of the offspring during development and after birth. Specifically we intend to 1]
Establish that maternal Ocn is necessary for proper adrenal gland development and function. We will also 2]
Establish genetically and in vivo that osteocalcin favors adrenal gland growth and steroidogenesis by signalling
directly in the adrenal cortices through its receptor Gpr158. A third purpose of this application is to determine
with precision the temporal course of osteocalcin’s effect on the adrenal gland development/function and
investigate how maternal osteocalcin affects this process in the offspring. We will use mouse genetic,
molecular and biochemical assays to investigate the molecular bases of the cross-talk between bone and the
adrenal gland through osteocalcin in the regulation of adrenal steroid production. Together, this application will
significantly advance our understanding of adrenal development and physiology in bony vertebrates by
describing a novel regulation of adrenal gland development and steroidogenesis, which originates from the
mother and is biologically relevant since its absence can be lethal.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring.
母体和胚胎来源的骨钙素协同作用,在后代中建立体内平衡。
- DOI:10.1038/s44319-023-00031-3
- 发表时间:2024
- 期刊:
- 影响因子:7.7
- 作者:CorreaPintoJunior,Danilo;CanalDelgado,Isabella;Yang,Haiyang;Clemenceau,Alisson;Corvelo,André;Narzisi,Giuseppe;Musunuri,Rajeeva;MeyerBerger,Julian;Hendricks,LaurenE;Tokumura,Kazuya;Luo,Na;Li,Hongchao;Oury,Franck;Ducy,Patrici
- 通讯作者:Ducy,Patrici
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Vijay K Yadav其他文献
Vijay K Yadav的其他文献
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{{ truncateString('Vijay K Yadav', 18)}}的其他基金
Taurine, an endogenously produced semi-essential micronutrient, as a regulator of lifespan and healthspan
牛磺酸,一种内源性产生的半必需微量营养素,作为寿命和健康寿命的调节剂
- 批准号:
10901014 - 财政年份:2023
- 资助金额:
$ 34.83万 - 项目类别:
Regulation of adrenal development and function by the mother's skeleton
母亲骨骼对肾上腺发育和功能的调节
- 批准号:
10493319 - 财政年份:2021
- 资助金额:
$ 34.83万 - 项目类别:
Regulation of adrenal development and function by the mother's skeleton
母亲骨骼对肾上腺发育和功能的调节
- 批准号:
10366329 - 财政年份:2021
- 资助金额:
$ 34.83万 - 项目类别:
MOLECULAR AND GENETIC DISSECTION OF SEROTONIN REGULATION OF BONE MASS
血清素对骨量调节的分子和基因剖析
- 批准号:
7772521 - 财政年份:2009
- 资助金额:
$ 34.83万 - 项目类别:
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