A compendium of complete primate reference genomes to facilitate conservation, genomics, and ecology
完整的灵长类动物参考基因组汇编,以促进保护、基因组学和生态学
基本信息
- 批准号:10675823
- 负责人:
- 金额:$ 55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationBiocompatible MaterialsBiodiversityBiologyCell LineCollectionCommunicable DiseasesCommunitiesCytogeneticsDNADataDepositionEcologyEnsureEvolutionGenerationsGenesGenomeGenomicsGraphHaplotypesHumanHuman GenomeInformation ResourcesMacacaMedical ResearchMethodsMonkeysPan GenusPongidaePopulationPrimatesRecording of previous eventsResearchResearch PersonnelResourcesSequence AlignmentSourceTechnologyValidationVariantWorkbasegenome annotationgenome browsergenome resourcehuman pangenomehuman reference genomeimprovedinsightnanoporenonhuman primateopen datapan-genomereference genomescaffoldvertebrate genome
项目摘要
Our understanding of primate evolution was transformed by the sequencing and assembly of the human
reference genome which identified the content and context of genes shared amongst the many different taxa in
the primate lineage. Subsequent efforts to assemble the genomes of chimpanzees, macaques, and other nonhuman primates further accelerated our under- standing of these and related species. Problematically, these
genomes were of substantially lesser quality than the human genome and often relied on the human genome for
long-range scaffolding. Recently however, the advent of long-read sequencing technologies have enabled de
novo con- struction of complete, accurate vertebrate genome assemblies. These technological advances have
supported renewed assemblies of a handful of apes and monkeys which are vastly improved providing unique
insights into the evolution and biology of these species. Nevertheless, complete, accurate, reference quality
genomes are lacking for the vast majority of the ~500 extant species of primates. Here we propose to construct
complete reference genomes from 50 diverse primate species spanning 75 million years of evolution. Using
state-of-the-art long-read sequencing and assem- bly methods we will sequence, assemble, annotate, align, and
disseminate these genomes as a resource for the community. Source DNA will be derived from the Integrated
Primate Bioma- terials and Information Resource (IPBIR) at the Coriell Institute for Medical Research
(Coriell), from a high quality, low-passage, cytogenetically verified collection of cell lines. This resource will
greatly enhance the potential for research that will advance our understanding of primate evolutionary history,
population genomics, infectious disease, human origins, and primate biodiversity and conservation.
人类的测序和组装改变了我们对灵长类进化的理解
参考基因组,它确定了在许多不同的类群中共享的基因的内容和背景
灵长类的血统。随后收集黑猩猩、猕猴和其他非人类灵长类动物的基因组的努力进一步促进了我们对这些物种和相关物种的了解。有问题的是,这些
基因组的质量比人类基因组低得多,通常依赖于人类基因组
远程脚手架。然而,最近长读测序技术的出现使得
构建完整、准确的脊椎动物基因组组合。这些技术进步已经
支持少数类人猿和猴子的更新组装,这些组件得到了极大的改进,提供了独特的
对这些物种的进化和生物学的洞察。尽管如此,完整、准确、参考质量
现存的约500种灵长类动物中,绝大多数缺乏基因组。在这里,我们建议构建
来自50个不同灵长类物种的完整参考基因组,跨越7500万年的进化。vbl.使用
最先进的长读测序和组装方法,我们将对其进行排序、组装、注释、对齐和
将这些基因组作为社区资源进行传播。源DNA将从集成的
科里尔医学研究所灵长类生物材料与信息资源
(Coriell),来自高质量、低传代、细胞遗传学验证的细胞系收集。此资源将
极大地增强了研究的潜力,这将促进我们对灵长类进化史的理解,
种群基因组学、传染病、人类起源、灵长类生物多样性和保护。
项目成果
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