The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence

项目摘要 该奖学金的目标是准备申请人，西娅森格-卡彭特，作为一个护士科学家学习 青少年睡眠、不良童年经历（ACE）和相关症状之间的关系， 结果。为此，拟议的研究金由两个相辅相成的组成部分组成：（1）培训计划 包括正式培训，指导，实践研究，手稿出版，和专业 发展活动和（2）一个研究项目，将进一步了解睡眠如何影响 ACE、心理健康症状和持续性或复发性疼痛（PRP）之间的关系 青春期申请人将得到一个强大的导师团队的支持， 密歇根护理学院和耶鲁护理学院。导师团队共同提供以下方面的专业知识： 青少年睡眠、疼痛和相关症状以及ACE暴露。培训计划将帮助 申请人开发：a）青少年睡眠，PRP和ACE暴露后遗症方面的专业知识，B） 纵向，多元数据分析的方法技能和c）从事研究的传播 调查结果和专业网络活动。 睡眠不足影响多达三分之二的美国青少年，是PRP，焦虑和抑郁的风险因素。 萧条ACE暴露也同样普遍，影响了大约一半的美国青少年，并且与 有PRP和精神健康症状重要的是，睡眠不足可能会减轻ACE的作用 对其他健康结果的影响。然而，人们对睡眠不足如何影响睡眠知之甚少。 ACE暴露，心理健康症状和PRP之间的关系在青春期也没有这些 关系因种族、民族、社会经济地位（SES）和性别而异。因此，建议的目标 项目是1）确定睡眠不足是否以及如何调节ACE对PRP的间接影响 2）描述这些关系如何因种族、民族、社会经济地位和 性所有目标都将使用青少年大脑认知发展研究进行调查，这是一项正在进行的NIH- 美国青年发展的纵向研究。 这个拟议的项目整合了健康公平和人口与社区健康的研究视角 在国家护理研究所的战略计划中概述。通过将睡眠确定为一种可改变的 作为干预目标，我们的研究结果有可能减少青少年暴露于 ACE和减轻种族，民族，社会经济和性别为基础的不平等的健康结果。

PROJECT SUMMARY The goal of this fellowship is to prepare the applicant, Thea Senger-Carpenter, as a nurse-scientist studying relationships among adolescent sleep, adverse childhood experiences (ACEs), and associated symptoms and outcomes. To that end, the proposed fellowship consists of two complementary components: (1) a training plan comprising formal training, mentorship, hands-on research, manuscript publication, and professional development activities and (2) a research project that will further our understanding of how sleep affects the relationships among ACEs, mental health symptoms and persistent or recurrent pain (PRP) during adolescence. The applicant will be supported by a strong mentorship team with sponsors at the University of Michigan School of Nursing and Yale School of Nursing. Together, the mentorship team provides expertise in adolescent sleep, pain and associated symptoms, and ACE exposure. The training program will help the applicant develop: a) expertise in adolescent sleep, PRP, and the sequelae of ACE exposure, b) methodological skills in longitudinal, multivariate data analysis and c) engage in the dissemination of research findings and professional networking activities. Sleep deficiency affects up to two-thirds of American adolescents and is a risk factor for PRP, anxiety, and depression. ACE exposure is similarly prevalent, affecting around half of U.S. teens, and has been associated with both PRP and mental health symptoms. Importantly, sleep deficiency may moderate the effect of ACE exposure on other health outcomes. However, little is known about how sleep deficiency impacts the relationships among ACE exposure, mental health symptoms, and PRP across adolescence nor how these relationships differ by race, ethnicity, socioeconomic status (SES), and sex. Thus, the aims of the proposed project are 1) to determine whether and how sleep deficiency moderates the indirect effect of ACEs on PRP through mental health symptoms and 2) to describe how these relationships differ by race, ethnicity, SES, and sex. All aims will be investigated using the Adolescent Brain Cognitive Development Study, an ongoing NIH- funded longitudinal study of youth development in the United States. This proposed project integrates the research lenses of health equity and population and community health outlined in the National Institute of Nursing Research's strategic plan. By identifying sleep as a modifiable target for intervention, our findings have the potential to reduce the symptom burden of adolescents exposed to ACEs and mitigate racial, ethnic, socioeconomic, and sex-based inequities in health outcomes.