Muscle Fatigue's Impact on Gait Mechanics and Neuromuscular Control in Knee Osteoarthritis

肌肉疲劳对膝骨关节炎步态力学和神经肌肉控制的影响

• 批准号: 10676554
• 负责人: Skylar Holmes
• 金额: $ 4.49万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-21 至 2025-09-20
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676554
• 关键词: Accelerometer; Acute; Address; Adopted; Adult; Age; Ankle; Arthralgia; Biomechanics; Chronic; Cross-Sectional Studies; Data; Degenerative polyarthritis; Development; Distal; Elderly; Electromyography; Evaluation; Exercise; Extensor; Fatigue; Female; Flexor; Functional disorder; Gait; Goals; Hip region structure; Impairment; Individual; Intervention; Investigation; Isometric Exercise; Isotonic Exercise; Joints; Knee; Knee Osteoarthritis; Knowledge; Link; Measures; Mechanics; Medical; Mission; Monitor; Motion; Motor; Motor Cortex; Movement; Muscle; Muscle Fatigue; Muscle function; Muscular Atrophy; Musculoskeletal; Neurologic; Neuromechanics; Neuronal Plasticity; Numeric Rating Scale; Pain; Pattern; Peripheral; Persons; Physical Capacity; Physical Function; Physical Performance; Physical activity; Physiological; Population; Psyche structure; Public Health; Reporting; Research Design; Research Personnel; Severities; Source; Speed; Spinal Cord; Standardization; Symptoms; Testing; Time; Torque; Training; Transcranial magnetic stimulation; United States National Institutes of Health; Vulnerable Populations; Walking; Woman; Work; aging population; chronic pain; clinically relevant; disability; functional improvement; healthspan; improved; improved mobility; male; men; neuromuscular; neuromuscular function; neurophysiology; novel strategies; prevent; response; sedentary; sensory system; skill acquisition; treadmill; verbal; years lived with disability

Project Summary Fatigue, lack of physical and/or mental energy, is a common reported symptom with osteoarthritis (OA) that may limit physical capacity and contribute to disability. In healthy older adults, muscle fatigue has been proposed as a key contributor to symptoms of fatigue. Knee extensor muscle dysfunction, including lower isometric and isokinetic torques and altered muscle activation patterns, are common with knee osteoarthritis (KOA). Together these changes in neuromuscular function may increase locomotor muscle fatigue in KOA compared to age-matched controls, as a greater percentage of the muscle’s capacity must be used for daily activities such as walking. To date, evidence to explain whether and how muscle fatigue may alter control and coordination of movement in KOA is limited. Our working hypothesis is that KOA-related neuromuscular changes may exacerbate locomotor muscle fatigue (Aim 1) and alter the neuro-mechanical response to muscle fatigue during gait (Aim 2), thereby contributing to mobility declines. In healthy adults, central and peripheral mechanisms can both contribute to muscle fatigue. However, whether the source of fatigue in individuals with KOA is central or peripheral is unclear which may be due to maladaptive neuroplastic changes that occur with KOA. To assess and compare the mechanisms for loss of force with a prolonged walk in individuals with KOA we will use transcranial magnetic stimulation to measure motor cortex excitability and inhibition (Aim 3). To test these hypotheses, data will be gathered on 2 groups of 10 men and 10 women: KOA (65-80 years) and older healthy controls (70-80 years). Both groups will be relatively sedentary, which will be verified quantitatively using accelerometry. In this cross-sectional study design, we will implement our new physiologically and clinically relevant 30-minute treadmill walk to induce knee extensor muscle fatigue and then quantify the response with measures of gait mechanics, electromyography, physical performance, and motor cortex excitability. The problem to be addressed, muscle fatigue in KOA, and its impact on mobility is significant and currently prevents many older adults from achieving an optimal health span. Understanding the mechanisms underlying changes in physical function, such as muscle fatigue in individuals with KOA will allow for a better understanding of how to optimize interventions in this population. The completion of the project and the proposed training plan activities including skill development in new experimental and advanced computational approaches as well as professional development activities will have a significant, positive impact on the development of the PI as an independent researcher, contributing to the stated goals of the NIH to enhance training of a diverse work force.

项目概要 疲劳、缺乏体力和/或精神能量是骨关节炎 (OA) 的常见症状， 可能会限制身体能力并导致残疾。在健康的老年人中，肌肉疲劳已 被认为是疲劳症状的一个关键因素。膝关节伸肌功能障碍，包括下肢伸膝肌功能障碍 等长和等速扭矩以及改变的肌肉激活模式在膝骨关节炎中很常见 （KOA）。神经肌肉功能的这些变化可能会增加 KOA 的运动肌疲劳 与年龄匹配的对照相比，因为每天必须使用更大比例的肌肉能力 步行等活动。迄今为止，有证据可以解释肌肉疲劳是否以及如何改变控制力和 KOA 的运动协调受到限制。我们的工作假设是，KOA 相关的神经肌肉 变化可能会加剧运动肌肉疲劳（目标 1）并改变对肌肉的神经机械反应 步态疲劳（目标 2），从而导致活动能力下降。在健康成人中，中枢和外周 机制都会导致肌肉疲劳。然而，疲劳的根源是否是患有以下疾病的人： KOA 是中枢性的还是外周性的尚不清楚，这可能是由于发生的适应不良的神经塑性变化所致。 科阿。评估和比较 KOA 患者长时间行走导致力量丧失的机制 我们将使用经颅磁刺激来测量运动皮层的兴奋性和抑制性（目标 3）。到 为了检验这些假设，将收集 2 组 10 名男性和 10 名女性的数据：KOA（65-80 岁）和 老年健康对照（70-80 岁）。两组都会相对久坐，这一点待验证 使用加速度计进行定量。在这个横断面研究设计中，我们将实施我们的新方法 生理和临床相关的 30 分钟跑步机步行可引起膝伸肌疲劳， 然后通过步态力学、肌电图、身体表现等指标来量化反应 运动皮层的兴奋性。要解决的问题是 KOA 的肌肉疲劳及其对活动能力的影响 显着，目前阻碍许多老年人实现最佳健康寿命。理解 身体功能变化的机制，例如 KOA 患者的肌肉疲劳，将 以便更好地了解如何优化针对该人群的干预措施。完成 项目和拟议的培训计划活动，包括新实验和 先进的计算方法以及专业发展活动将产生重大的、 对 PI 作为独立研究员的发展产生积极影响，为既定目标做出贡献 NIH 加强对多元化劳动力的培训。