Genomic Approaches to Population Health in Multi-Ethnic Hospital Systems

多民族医院系统中人口健康的基因组方法

• 批准号: 10676210
• 负责人: Valerie A Arboleda
• 金额: $ 76.86万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-16 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10676210
• 关键词: Address; Adoption; African American population; Architecture; Asthma; Automobile Driving; Biological Markers; Categories; Chronic Disease; Clinical; Complex; Computerized Medical Record; Coupled; Data; Databases; Decision Making; Detection; Diabetes Mellitus; Diagnosis; Diagnostic; Discipline; Disease; Disease Outcome; Electronic Health Record; Engineering; Ensure; Ethnic Origin; Ethnic Population; European; Evaluation; Family history of; Fostering; Gene Frequency; Genetic; Genetic Databases; Genomic approach; Genomic medicine; Genomics; Genotype; Goals; Health; Health system; Healthcare; Healthcare Systems; Hospitals; Hypertension; Hypertrophic Cardiomyopathy; Individual; Institution; International; Intervention; Investigation; Investments; Knowledge; Link; Measures; Medical; Medicine; Methods; Modeling; Modernization; Monitor; Outcome; Pathogenicity; Patient Care; Patients; Pattern; Penetrance; Performance; Persons; Phenotype; Policy Making; Population; Population Genetics; Population Heterogeneity; Prevalence; Race; Rare Diseases; Research; Risk; Risk Assessment; Science; Statistical Methods; Stevens-Johnson Syndrome; System; Taiwan; Technology; Testing; Therapeutic; Translating; Translational Research; Variant; Work; biobank; burden of illness; clinical care; clinical database; clinical phenotype; clinical practice; clinical risk; cohort; disorder prevention; disorder risk; ethnic minority population; genetic information; genetic risk factor; genome-wide; genomic data; health care service utilization; health disparity; human disease; identity by descent; implementation barriers; improved; interdisciplinary collaboration; multi-ethnic; new technology; novel; patient population; polygenic risk score; population based; population health; portability; precision medicine; racial population; rare genetic disorder; rare mendelian disorder; repository; success; tool; trait; whole genome

Project Summary Genomic medicine is a rapidly emerging medical discipline that incorporates the use of genomic information in patient care. Understanding an individual's genetic information holds the potential to improve diagnostic and therapeutic decision-making in clinical care, impact health outcomes and inform policy making. Yet the genomic datasets driving these decisions are often focused on populations of European descent. When these limited discoveries drive genomic medicine, understudied groups are frequently the last to benefit from advances in research, technology and clinical best practices. For true adoption, precision medicine needs to account for genomic diversity inherent to modern health systems. To address the importance of understanding disease risk in fine-scale populations present in modern health systems, and foster opportunities for advancement of genomic medicine in diverse populations, we have assembled a multi-ethnic cohort of over one million genotyped individuals from five international biobanks in health systems linked to electronic medical records. Leveraging this unique research cohort from our institutes, we will engineer fine-scale population detection and monitoring for population health powered by novel statistical and population genetics methods. These in turn can help us understand disease prevalence and refine our understanding of clinical variant pathogenicity. The systems we develop within hospitals will help characterize risk profiles for both rare (via Phenotype Scores) and common (via Polygenic Scores) traits, a necessary step to work in realistic, modern multi-ethnic hospital settings. These goals are implemented through three specific aims: Aim 1: Implement a monitoring system for differences in disease burden between fine-scale populations defined via identity-by-descent (IBD) inferred from genome-wide data across multiple biobanks. In so doing, we will apply a high-throughput, portable method to improve fine-scale ancestry and use it to improve disease and trait monitoring across multiple health systems. Aim 2: Improve our characterization of clinical variant pathogenicity, penetrance and expressivity via improved allele frequency examination through the fine-scale populations determined in Aim 1. Aim 3: Model risk via improved phenotype risk score (PheRS) for rare disease and polygenic risk score (PRS) for common traits across the fine-scale populations determined in Aim 1. We will develop improved trans- ethnic risk models and demonstrate their utility in improving our population-based understanding of disease outcomes. Our long-collaborating interdisciplinary team including clinical, statistical, and population geneticists has already produced preliminary data demonstrating not only a high likelihood of success, but also a desire and capacity to translate results into implemented changes in clinical care. This project will drive a new understanding of human disease, as well as opportunities for new health care interventions, particularly for currently understudied ethnic minority populations, thereby improving precision medicine for all.

项目摘要 基因组医学是一门迅速兴起的医学学科，它将基因组信息的使用整合到 病人护理了解个体的遗传信息有可能改善诊断和 临床护理中的治疗决策，影响健康结果并为决策提供信息。然而 推动这些决定的基因组数据集通常集中在欧洲血统的人群上。当这些 有限的发现推动基因组医学，未被研究的群体往往是最后受益于 研究、技术和临床最佳实践的进步。为了真正采用，精准医疗需要 解释现代卫生系统固有的基因组多样性。 为了解决理解现代医学中精细规模人群疾病风险的重要性， 卫生系统，并为不同人群的基因组医学发展创造机会，我们已经 从五个国际生物库中收集了超过一百万个基因型个体的多种族队列， 与电子医疗记录相关联的医疗系统。利用我们研究所的这一独特的研究群体， 我们将设计精细规模的人口检测和监测人口健康， 统计学和群体遗传学方法。这些反过来可以帮助我们了解疾病的流行程度， 完善我们对临床变异致病性的理解。我们在医院内部开发的系统将有助于 描述罕见（通过表型评分）和常见（通过多基因评分）特征的风险特征，a 这是在现实的、现代化的多民族医院环境中开展工作的必要步骤。实现这些目标 通过三个具体目标： 目标1：实施一个监测系统，监测精细规模人群之间的疾病负担差异 通过从多个生物库的全基因组数据推断的血统同一性（IBD）来定义。我们这样做 将应用高通量，便携式方法来改善精细规模的祖先，并用它来改善疾病， 在多个卫生系统中进行特征监测。 目的2：通过改进的方法来改进我们对临床变异致病性、特异性和表达性的表征。 通过目标1中确定的细规模群体进行等位基因频率检查。 目的3：通过罕见病的改良表型风险评分（PheRS）和多基因风险评分（PRS）建立风险模型 目标1中确定的精细规模种群的共同性状。我们将开发更好的跨- 种族风险模型，并证明它们在改善我们对疾病的人口基础理解方面的效用 结果。 我们长期合作的跨学科团队，包括临床，统计和人口遗传学家， 已经产生的初步数据不仅表明成功的可能性很高，而且还表明希望， 将结果转化为临床护理中实施的变化的能力。该项目将推动新的 了解人类疾病，以及新的卫生保健干预措施的机会，特别是 目前，对少数民族人口的研究不足，从而改善了对所有人的精准医疗。