Multimorbidity Trajectories, Psychosocial Resilience and Stress, and Risk of Dementia and Poor Cognitive Functioning
多重发病轨迹、社会心理弹性和压力、痴呆症和认知功能不良的风险
基本信息
- 批准号:10684061
- 负责人:
- 金额:$ 18.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdverse eventAffectAgingAlzheimer disease preventionAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAttenuatedBiological AgingBlack PopulationsBuffersCause of DeathChronicChronic DiseaseChronic stressClinicalClinical Course of DiseaseCognitionCognitiveCox ModelsDataDementiaDevelopmentDiscriminationDiseaseDisease ProgressionDisparityElderlyEpisodic memoryFoundationsGenderGrowthHealthHealth and Retirement StudyHeterogeneityImpaired cognitionInequalityInterventionInvestigationKnowledgeLife Cycle StagesLinkLiteratureMethodologyMethodsModelingNatureOutcomePatternPopulationPopulation HeterogeneityPrevalencePrevention strategyProcessProspective cohortPsychosocial FactorPsychosocial StressRaceResearchRiskRisk FactorsRoleScholarshipSelf EfficacyShort-Term MemorySocial isolationSocial supportSpecific qualifier valueStressTherapeutic InterventionTimeTreatment/Psychosocial EffectsVariantWomanWorkcognitive changecognitive functioncognitive reservedementia riskdesigndisease disparitydisorder riskenhancing factorgender differencegender disparityhealth datahealthy agingimprovedinsightmild cognitive impairmentmortalitymultiple chronic conditionsnovelperson centeredpopulation basedpsychosocialracial differenceracial disparityresiliencerisk stratificationtheoriestherapy designverbal
项目摘要
PROJECT SUMMARY / ABSTRACT
Alzheimer’s Disease (AD), the sixth leading cause of death in the US, is the most common form of
dementia in later life. Substantial heterogeneity in the course of disease progression, AD prevalence, and
mortality exist by gender and race. Yet, variations in the distribution and the relative importance of risk factors,
such as multimorbidity, that may inform gender and racial differences in AD risk and cognitive change over
time are not well understood. Data-driven strategies capturing the dynamic nature of chronic disease
accumulation may offer critical insight regarding differences in dementia risk and cognitive functioning by
gender and race. Further, a robust literature hypothesizes linkages between psychosocial resilience and stress
with dementia risk and cognitive functioning. However, the extent to which these factors enhance or attenuate
dementia risk and poor cognitive functioning merits systematic investigation and is in alignment with new
priorities for AD and aging research. To address these gaps the proposed work will investigate the association
between multimorbidity trajectories, psychosocial resilience/stress, dementia risk and changes in cognitive
functioning using data from the Health Retirement Study (2000-2018). We propose two aims: 1) assess the
effect of psychosocial resilience (e.g., perceived social support, self-efficacy, and mastery) on the relationship
between multimorbidity trajectories and change in cognitive functioning and incident dementia; and 2) assess
the effect of psychosocial stress (e.g., discrimination, chronic stress, social isolation) on the relationship
between multimorbidity trajectories and change in cognitive functioning and incident dementia. Specifying
multimorbidity trajectory classes that differentially predict dementia risk and poor cognitive functioning
represents a valuable contribution in: clarifying factors that propagate gender and racial disparities in late life
progressive cognitive decline and dementia risk; informing the design of interventions and preventive strategies
targeting psychosocial resilience and stress among populations at greatest risk; and improving precision in
stratifying risk for poor cognitive function to delay the development and progression of AD.
项目总结/摘要
阿尔茨海默病(AD)是美国第六大死亡原因,是阿尔茨海默病最常见的形式。
老年痴呆症后期疾病进展过程、AD患病率和
死亡率是按性别和种族划分的。然而,风险因素的分布和相对重要性的变化,
如多Morphism,这可能会告知AD风险和认知变化的性别和种族差异,
时间不太了解。数据驱动的战略捕捉慢性病的动态本质
累积可能提供关于痴呆风险和认知功能差异的重要见解,
性别和种族。此外,一个强大的文献假设之间的联系心理社会弹性和压力
有痴呆风险和认知功能。然而,这些因素增强或减弱的程度
痴呆风险和认知功能差值得系统研究,并与新的
AD和老龄化研究的优先事项。为了解决这些差距,拟议的工作将调查协会
多发病轨迹,心理社会弹性/压力,痴呆风险和认知变化之间的关系
使用健康退休研究(2000-2018)的数据。我们提出两个目标:1)评估
心理社会复原力的影响(例如,知觉社会支持、自我效能和掌握)对关系的影响
多项运动轨迹与认知功能变化和痴呆事件之间的关系;以及2)评估
心理社会压力的影响(例如,歧视、长期压力、社会孤立)对关系的影响
在认知功能改变和痴呆事件之间的联系。指定
不同的预测痴呆风险和认知功能差的多项运动轨迹分类
代表了一个宝贵的贡献:澄清因素,传播性别和种族差异在晚年生活
进行性认知能力下降和痴呆风险;为干预措施和预防战略的设计提供信息
针对风险最大人群的心理社会复原力和压力;
对认知功能差的风险进行分层,以延缓AD的发展和进展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kellee White Whilby其他文献
Correlates of longitudinal patterns of racial discrimination in midlife and older Black adults: Evidence from the health and retirement study
中年及老年黑人长期遭受种族歧视模式的相关因素:来自健康与退休研究的证据
- DOI:
10.1016/j.socscimed.2025.118194 - 发表时间:
2025-09-01 - 期刊:
- 影响因子:5.000
- 作者:
Kellee White Whilby;Shuo J. Huang;Bethany A. Bell;Kaitlynn Robinson-Ector;Mario Sims;David R. Williams - 通讯作者:
David R. Williams
Multilevel Racism and Discrimination and Cardiovascular Disease and Related Biopsychosocial Mechanisms: An Integrated Scoping and Literature Review and Future Research Agenda
- DOI:
10.1007/s11886-025-02238-3 - 发表时间:
2025-06-04 - 期刊:
- 影响因子:3.300
- 作者:
Danielle L. Beatty Moody;Elizabeth J. Pantesco;Ayla Novruz;Nedelina Tchangalova;Richard C. Sadler;Kellee White Whilby;Jason Ashe;Gilbert C. Gee;LaBarron K. Hill;Shari R. Waldstein - 通讯作者:
Shari R. Waldstein
Kellee White Whilby的其他文献
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{{ truncateString('Kellee White Whilby', 18)}}的其他基金
Multimorbidity Trajectories, Psychosocial Resilience and Stress, and Risk of Dementia and Poor Cognitive Functioning
多重发病轨迹、社会心理弹性和压力、痴呆症和认知功能不良的风险
- 批准号:
10524911 - 财政年份:2022
- 资助金额:
$ 18.77万 - 项目类别:
Perceived Discrimination Trajectories and Cognitive Functioning Among Older Black Adults
老年黑人的感知歧视轨迹和认知功能
- 批准号:
9808361 - 财政年份:2019
- 资助金额:
$ 18.77万 - 项目类别:
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