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Highly Efficient MRI Pulse Sequences for High Resolution Physiological and Functional Brain Imaging

用于高分辨率生理和功能脑成像的高效 MRI 脉冲序列

基本信息

批准号：
10684334
负责人：
Alexander Beckett
金额：
$ 135.1万
依托单位：
ADVANCED MRI TECHNOLOGY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10684334
关键词：
3-Dimensional Acceleration Area Blood Blood Vessels Brain Brain imaging Cerebrovascular Circulation Clinical Protocols Code Computer software Data Deep Brain Stimulation Development Diagnosis Disease Documentation Drainage procedure Echo-Planar Imaging Environment Evaluation Functional Imaging Functional Magnetic Resonance Imaging Human Image Imaging Techniques Magnetic Resonance Imaging Maps Measurement Measures Medical Neocortex Neurons Neuropsychology Noise Performance Physicians Physics Physiologic pulse Physiological Process Resolution Scientist Signal Transduction Site Slice Software Tools Specificity Speed TBI Patients Techniques Technology Testing Time Validation Variant Venous Work analysis pipeline arterial spin labeling blood flow measurement blood oxygen level dependent brain abnormalities cerebral blood volume data analysis pipeline high resolution imaging improved innovation neocortical nervous system disorder neural neural circuit neuronal circuitry neurovascular non-invasive imaging novel protocol development public repository quality assurance reconstruction temporal measurement

项目摘要

Summary This project will develop MRI physiological imaging with higher spatial and temporal resolution, larger brain coverage, and faster accelerated pulse sequences. The physiologic images have contrasts of microvascular- weighted blood oxygen level dependent (BOLD), cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the techniques to be developed are largely insensitive to venous blood contributions to signal, unlike traditional BOLD echo planar imaging (EPI) sequences, and thus they are extremely useful for precision imaging of physiological markers in neurological disorders and for higher specificity in cortical layer fMRI, enabling higher granularity in human neurocircuitry imaging. Novel acceleration techniques for each pulse sequence will be incorporated to increase slice-volume coverage and improve signal to noise ratio (SNR) and point spread function (PSF) in signal localization. Sequence development and evaluations will be performed at several 3T and 7T imaging sites. We will develop a software package with advanced variants of several pulse sequences: zoomed 3D gradient-and-spin-echo (GRASE), arterial spin labeling (ASL) for CBF imaging, slice- saturation slab- inversion vascular space occupancy (SS-SI-VASO) for CBV imaging, and the novel VASO technique with “multiple acquisitions with global excitation cycling” (MAGEC)-VASO to achieve whole brain coverage. The software package will also include a modular analysis pipeline for use by neuroscientists and physicians without the need for extensive MR-physics or coding expertise. Achieving non-invasive imaging of neuronal circuits in the human brain will allow neuroscientists to study normal brain processes and allow medical scientists to study neurocircuitry changes and neurological diseases. Currently, high-resolution fMRI technology could be used to identify fMRI of neural activity at different cortical depths, but is severely limited by poorly localized signal from venous drainage in the cortex. This project innovates new, robust 3D fMRI imaging sequences that eliminate venous contamination, thus affording high fidelity mapping of fine-scale neuronal circuitry compared to current gradient echo EPI BOLD imaging.

总结